Pilomatrix-like High-grade Endometrial Carcinoma: An Underdiagnosed Entity With Aggressive Clinicopathologic Features [0.03%]
类似皮瘤矩阵的高度恶性子宫内膜癌：一种具有侵袭性临床病理特征的未被充分诊断的实体肿瘤
Feng Zhou,Lei Qin,Suming Huang et al.
Feng Zhou et al.
Pilomatrix-like high-grade endometrial carcinoma (PiMHEC) is a rare and aggressive variant of endometrial carcinoma often misdiagnosed due to overlapping features with other high-grade malignancies. This study characterizes its clinicopatho...
Consensus in Oral Epithelial Dysplasia Classification: A Comparative Analysis of H&E-stained Sections With and Without p53/p16 Immunohistochemistry [0.03%]
口腔上皮不典型增生分类中的共识：H&E染色与p53/p16免疫组化结果的比较分析
Ivan J Stojanov,Kelly Yi Ping Liu,Christina McCord et al.
Ivan J Stojanov et al.
Diagnosis and classification of oral epithelial dysplasia (OED) is critical to identifying and prognosticating patients at risk of squamous cell carcinoma (SCC). However, conventional 3-tiered and 2-tiered grading systems suffer from poor i...
Clinicopathologic and Molecular Analysis of Malignant Neoplasms With Yolk Sac Tumor Differentiation in Women 40 Years of Age and Older [0.03%]
绝经后女性卵巢肿瘤中具有卵黄囊亚型分化的恶性生殖细胞肿瘤的临床病理和分子特征分析
Tricia A Numan,Brigitte M Ronnett,Lisa Haley et al.
Tricia A Numan et al.
Gynecologic yolk sac tumors (YSTs) are more commonly encountered in children and young women as pure or mixed germ cell tumors and are rarely observed in older women. YSTs in older women are sometimes accompanied by a Müllerian-type carcin...
Comparative Molecular Profiling of "Mixed Endometrioid Adenocarcinoma and Adenosarcoma" of the Uterus and Ovary: A Multi-institutional Series of 14 Cases [0.03%]
子宫和卵巢“混合性内膜样腺癌和腺肉瘤”的分子特征分析：14例多中心病例系列
Lucy X Ma,Jennifer A Bennett,Melissa Y Tjota et al.
Lucy X Ma et al.
"Mixed endometrioid adenocarcinoma and adenosarcoma" is a recently described malignancy of the uterus and ovary characterized by discrete components of Mullerian adenosarcoma and typically low-grade endometrioid adenocarcinoma. Its molecula...
Clinicopathologic Characteristics of Immune Checkpoint Inhibitor-related Pancreatitis [0.03%]
免疫检查点抑制剂相关胰腺炎的临床病理特征
Feidi Chen,Monika Vyas,Matthew Gosse et al.
Feidi Chen et al.
The advent of immune checkpoint inhibitors (ICIs), although associated with adverse events, has heralded a new era in cancer therapy. ICI-related pancreatitis is a rare adverse effect of ICIs. The nonspecific clinical manifestations have po...
High FCGR2B Expression Can Identify Low-tumor-burden Follicular Lymphoma Patients Who Do Not Require Any Antilymphoma Therapy for a Long Term [0.03%]
高FCGR2B表达可识别出长期无需抗淋巴瘤治疗的低肿瘤负荷 follicular lymphoma患者
Shotaro Watanabe,Hiroki Kato,Tohru Fujiwara et al.
Shotaro Watanabe et al.
Spontaneous regression or a long-term lack of obvious progression is often observed in patients with low-tumor-burden (LTB) follicular lymphoma (FL). However, conventional prognostic risk models are unable to precisely identify the patients...
CPZ: A Highly Sensitive Diagnostic Biomarker for the Differentiation Between Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma, Particularly in Poorly Differentiated Hepatocellular Carcinoma [0.03%]
CPZ：一种用于区分肝细胞癌和肝内胆管癌的高度敏感的诊断生物标志物，尤其是对于分化不良的肝细胞癌
Minying Deng,Rongkui Luo,Lingli Chen et al.
Minying Deng et al.
Carboxypeptidase Z (CPZ) is a newly identified member of the metallopeptidase family, primarily reported in rats; however, its distribution in normal human tissues and expression characteristics in tumor tissues remain unclear. This study u...
Molecular Analysis of Cutaneous Sarcomatoid Neoplasms Frequently Identifies Melanoma Driver Variants [0.03%]
皮肤肉瘤样肿瘤的分子分析常发现黑色素瘤驱动基因变异
Louise A Jackett,Catherine Mitchell,Cameron Snell et al.
Louise A Jackett et al.
Primary cutaneous neoplasms that lack definitive histologic and immunophenotypic evidence of differentiation are a heterogeneous group of tumors with diverse prognoses and management options. These include undifferentiated and dedifferentia...
HER2 mRNA Score From Quantitative ERBB2 mRNA Expression of Oncotype Dx: Can It Replace the HER2 Immunohistochemistry? [0.03%]
定量评估Oncotype DX中的ERBB2 mRNA表达分数用于替代HER2免疫组化检测？
Hyunwoo Lee,Jai Min Ryu,Se Kyung Lee et al.
Hyunwoo Lee et al.
As novel human epidermal growth factor receptor-2 (HER2) and drug conjugates have proven to be effective treatments for both HER2-positive breast cancer (BC) and HER2-low BC, the need to develop more accurate methods to quantify HER2 status...
NTRK Fusions in Xanthogranuloma, a Clinicopathologic and Molecular Analysis of 23 Cases [0.03%]
Xanthogranuloma中的NTRK融合：23例临床病理和分子分析
Brandon Umphress,Aofei Li,Matthew Kuhar et al.
Brandon Umphress et al.
Xanthogranuloma is the most common category of histiocytic neoplasia, with a range of clinical behaviors from solitary cutaneous lesions to multiple cutaneous lesions and less frequent cases with evolution to disseminated disease. Solitary ...