A Statement of the MDS on Biological Definition, Staging, and Classification of Parkinson's Disease [0.03%]
MDS帕金森病生物学定义、分期和分类声明
Francisco Cardoso,Christopher G Goetz,Tiago A Mestre et al.
Francisco Cardoso et al.
ANO3 as a Cause of Early-Onset Chorea Combined with Dystonia: Illustration of Phenotypic Evolution [0.03%]
ANO3作为早发性手足徐动症合并肌张力障碍的病因：表型演变实例分析
Luigi M Romito,Valentina Leta,Barbara Garavaglia et al.
Luigi M Romito et al.
Deep Brain Stimulation Improves Parkinson's Disease-Associated Pain by Decreasing Spinal Nociception [0.03%]
深部脑刺激通过减少脊髓痛觉增进帕金森病相关的止痛效果
Veit Mylius,Jan Harald Baars,Karsten Witt et al.
Veit Mylius et al.
Dopamine exerts antinociceptive effects on pain in PD at cortical and spinal levels, whereas only cortical effects have been described for DBS, so far. By assessing the nociceptive flexion reflex (NFR) threshold at medication on, and DBS ON...
Prevalence and Incidence of Parkinson's Disease in Latin America: A Meta-Analysis [0.03%]
拉丁美洲帕金森病患病率和发病率的荟萃分析
Dani J Kim,Ana L Isidro-Pérez,Michelle Doering et al.
Dani J Kim et al.
Background: Parkinson's disease (PD) is a rapidly growing neurodegenerative disorder, but up-to-date epidemiological data are lacking in Latin America. We sought to estimate the prevalence and incidence of PD and parkinso...
Motivational Vigor in Parkinson's Disease Requires the Short and Long Duration Response to Levodopa [0.03%]
左旋多巴的短时和长时间效应需要帕金森病中的动机活力
James A Brissenden,Teresa Scerbak,Roger L Albin et al.
James A Brissenden et al.
Background: Impaired movement vigor (bradykinesia) is a cardinal feature of Parkinson's disease (PD) and hypothesized to result from abnormal motivational processes-impaired motivation-vigor coupling. Dopamine replacement...
Brain Dynamics Complexity as a Signature of Cognitive Decline in Parkinson's Disease [0.03%]
帕金森病中大脑动力学复杂性作为认知衰退的标志
Eleonora Fiorenzato,Sadaf Moaveninejad,Luca Weis et al.
Eleonora Fiorenzato et al.
Background: Higuchi's fractal dimension (FD) captures brain dynamics complexity and may be a promising method to analyze resting-state functional magnetic resonance imaging (fMRI) data and detect the neuronal interaction ...
Serum Neurofilament Light Chain in Replication Factor Complex Subunit 1 CANVAS and Disease Spectrum [0.03%]
复制因子复合物亚基1基因变异的神经丝轻链血清学标志意义及临床表型研究
Ilaria Quartesan,Elisa Vegezzi,Riccardo Currò et al.
Ilaria Quartesan et al.
Background: Biallelic intronic AAGGG repeat expansions in the replication factor complex subunit 1 (RFC1) gene were identified as the leading cause of cerebellar ataxia, neuropathy, vestibular areflexia syndrome. Patients...
Optic Disc and Retinal Architecture Changes in Patients with Spinocerebellar Ataxia Type 2 [0.03%]
脊髓小脑性共济失调2型患者的盘状视网膜结构改变
Flávio Moura Rezende Filho,Neringa Jurkute,João Brainer Clares de Andrade et al.
Flávio Moura Rezende Filho et al.
Background: ATXN2 is the causative gene of spinocerebellar ataxia type 2 (SCA2) and has been implicated in glaucoma pathogenesis. Therefore, studying ocular changes in SCA2 could uncover clinically relevant changes. ...
DNAJC12 in Monoamine Metabolism, Neurodevelopment, and Neurodegeneration [0.03%]
DNAJC12在单胺代谢、神经发育和神经退行性疾病中的作用
Isaac Bul Deng,Jordan Follett,Mengfei Bu et al.
Isaac Bul Deng et al.
Recent studies show that pathogenic variants in DNAJC12, a co-chaperone for monoamine synthesis, may cause mild hyperphenylalaninemia with infantile dystonia, young-onset parkinsonism, developmental delay and cognitive deficits. DNAJC12 has...
The Genetic Drivers of Juvenile, Young, and Early-Onset Parkinson's Disease in India [0.03%]
印度青少年、年轻和早发性帕金森病的遗传驱动因素
Shan V Andrews,Prashanth L Kukkle,Ramesh Menon et al.
Shan V Andrews et al.
Background: Recent studies have advanced our understanding of the genetic drivers of Parkinson's disease (PD). Rare variants in more than 20 genes are considered causal for PD, and the latest PD genome-wide association st...