Phase 2a Randomized Controlled Trial of TPN-101, A Nucleoside Reverse Transcriptase Inhibitor, in Progressive Supranuclear Palsy [0.03%]
TPN-101（核苷逆转录酶抑制剂）治疗进行性核上性麻痹的II期临床试验
Andrew Satlin,Michael G Cordingley,Debra K Liebert et al.
Andrew Satlin et al.
Background: Preclinical and human brain postmortem studies indicate that progressive supranuclear palsy (PSP) is associated with increased expression of the retrotransposon Long Interspersed Nuclear Element-1 (L1Hs). L1Hs...
Pathogenic GBA1 Variants and their Interaction with the Gut-Microbiota-Brain Axis in Parkinson's Disease [0.03%]
GBA1致病基因变异及其与帕金森病肠-菌群-脑轴交互作用的关系研究
Helen Dainton-Howard,Phillip Engen,Kristi Lawrence et al.
Helen Dainton-Howard et al.
Léo Coutinho,Hélio A G Teive
Léo Coutinho
Integrative Multi-Omics Analysis Reveals Convergent Epigenome and Transcriptome Changes in Parkinson's Disease [0.03%]
整合多组学分析揭示帕金森病中表观基因组和转录组的汇聚变化
Mirco Macchi,Aurélien Ginolhac,Tony Heurtaux et al.
Mirco Macchi et al.
Background: The mechanisms that predispose dopaminergic neurons (DAN) to degeneration in Parkinson's disease (PD) are incompletely understood. Objective: ...
Raymond Y Lo,Tamara Pringsheim,Connie Marras
Raymond Y Lo
In celebration of the 40-year legacy of Movement Disorders Journal (MDJ), this historical reflection traces the evolution of epidemiological research in movement disorders through the lens of papers published in MDJ from 1986 through 2025. ...
Reply to: "Parkinson's Disease in Wartime: From Editorial to Emergency" [0.03%]
关于“从编辑部到战区：帕金森病的战争与和平”的回信
Mehri Salari,Sevim Soleimani,Masoud Etemadifar et al.
Mehri Salari et al.
Jaime Kulisevsky,Lidia Bojtos,Milica G Kramberger et al.
Jaime Kulisevsky et al.
Apathy is one of the most prevalent and disabling non-motor symptoms in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), collectively referred to as Lewy body disorders (LBDs). It is associated with reduced quality of life, acc...
Subthalamic Nucleus Deep Brain Stimulation Enhanced Long-Latency Reflex II in Parkinson's Disease Through Rapid Subthalamic-Cortical Modulation [0.03%]
苍白球内在侧脑深部刺激通过快速皮质-皮质回路改善帕金森病的迟发性反射II
Kai-Hsiang Stanley Chen,Yih-Chih Jacinta Kuo,Chang-Yu Jeng et al.
Kai-Hsiang Stanley Chen et al.
Background: The long-latency reflex (LLR), particularly LLR II elicited by peripheral stimulation, is considered a transcortical reflex and may reflect cortical-subcortical excitability. Its relevance as a biomarker for s...
By the Time the Ceiling Stains: Risk Factors, Prodromes, and the Two Windows of Prevention in Neurodegeneration [0.03%]
寻迹天花板上的污渍——神经变性疾病的危险因素、先兆及预防窗口
Jose-Alberto Palma
Jose-Alberto Palma