Digital Outcomes as Biomarkers of Disease Progression in Early Parkinson's Disease: A Systematic Review [0.03%]
数字结局作为帕金森病的生物标志物：系统性回顾研究
Pablo Rábano-Suárez,Natalia Del Campo,Isabelle Benatru et al.
Pablo Rábano-Suárez et al.
Outcomes derived from digital health technologies (DHTs) are promising candidate markers for monitoring Parkinson's disease (PD) progression. They have the potential to represent a significant shift in clinical research and therapeutic deve...
Cortical Functional Connectivity Changes in the Body-First and Brain-First Subtypes of Parkinson's Disease [0.03%]
帕金森病躯体为主型和大脑为主型的功能连接改变
Matteo Conti,Valentina D&#x;Onofrio,Roberta Bovenzi et al.
Matteo Conti et al.
Background: Rapid eye movement (REM) sleep behavior disorder (RBD) may precede motor symptoms in Parkinson's disease (PD) by years. According to a recent hypothesis, premotor RBD (pRBD) is a marker of the PD body-first su...
Environmental Risk Factors for Parkinson's Disease: A Critical Review and Policy Implications [0.03%]
帕金森病的环境风险因素：批判性评论及政策含义
Kajsa Atterling Brolin,Eva Schaeffer,Ashvin Kuri et al.
Kajsa Atterling Brolin et al.
The age-standardized prevalence of Parkinson's disease (PD) has increased substantially over the years and is expected to increase further. This emphasizes the need to identify modifiable risk factors of PD, which could form a logical entry...
Low-Frequency Deep Brain Stimulation in Non-Rapid Eye Movement Sleep Modifies Memory Retention in Parkinson's Disease [0.03%]
非快速眼动睡眠期间的低频深部脑刺激可改善帕金森病患者的记忆巩固
Damian M Herz,Jenny Blech,Yaroslav Winter et al.
Damian M Herz et al.
Background and objective: Memory impairment is a frequent and debilitating symptom in neurodegenerative disorders. The objective of this study was to provide proof-of-principle that deep brain stimulation during sleep can...
(TTTCA)exp Drives the Genotype-Phenotype Correlation and Genetic Anticipation in FCMTE1 [0.03%]
(TTTCA)n动态突变驱动FCMTE1患者的基因型与表现型的相关性及遗传早现现象
Xinhui Chen,Bo Wang,Haibin Xia et al.
Xinhui Chen et al.
Background: The pentanucleotide (TTTCA) repeat expansion (exp) insertion, along with the accompanying (TTTTA)exp, causes familial cortical myoclonic tremor with epilepsy (FCMTE). The genotype-phenotype correlations and in...
Genome Aggregation Database Version 4-Allele Frequency Changes and Impact on Variant Interpretation in Dystonia [0.03%]
全基因组聚合数据库第4版-扭转痉挛变异解读的等位基因频率变化及影响
Elisabetta Indelicato,Anna Eberl,Sylvia Boesch et al.
Elisabetta Indelicato et al.
Background: Population-scale databases majorly contribute to variant interpretation. The recently released Genome Aggregation Database (gnomAD) v4 offers a >5-fold increased sample size compared to v2.1.1. Pathogenic vari...
Shichan Wang,Ruwei Ou,Jingxuan Huang et al.
Shichan Wang et al.
Interpersonal Psychotherapy for the Treatment of Depression in Parkinson's Disease: Results of a Randomized Controlled Trial [0.03%]
针对帕金森病患者抑郁的间人心理疗法：随机对照试验结果
Diana Koszycki,Monica Taljaard,Jacques Bradwejn et al.
Diana Koszycki et al.
Background: Depression is a common nonmotor complication in Parkinson's disease (PD). However, few studies have evaluated the efficacy of first-line psychological therapies for depression in this patient population. ...
Skin Inflammatory Reactions in Patients with Continuous Subcutaneous Injection of Foslevodopa-Foscarbidopa Hydrate: Histopathology [0.03%]
连续皮下注射左旋多巴-卡比多巴治疗患者的皮肤炎症反应：组织病理学观察
Nagisa Yoshihara,Noriko Nishikawa,Rei Watanabe et al.
Nagisa Yoshihara et al.
Stimulation-Evoked Resonant Neural Activity in the Subthalamic Nucleus Is Modulated by Sleep [0.03%]
睡眠可以调节皮层丘脑核的共振神经活性
Christoph Wiest,Thomas G Simpson,Alek Pogosyan et al.
Christoph Wiest et al.
Background: Deep brain stimulation is a treatment for advanced Parkinson's disease and currently tuned to target motor symptoms during daytime. Parkinson's disease is associated with multiple nocturnal symptoms such as ak...