David J Samuelson
David J Samuelson
Transcriptome analysis reveals IGF-dependent and IGF-independent mechanisms affected by loss of IGF binding protein-2b in rainbow trout [0.03%]
转录组分析揭示了辐鳍鱼成纤维细胞生长因子结合蛋白-2b丢失的IGF依赖和非IGF依赖机制
Beth M Cleveland,Lisa Radler,Munetaka Shimizu
Beth M Cleveland
In teleosts, insulin-like growth factor binding protein-2b (IGFBP-2b) is the major carrier of serum insulin-like growth factor (IGF). A line of gene edited rainbow trout (2bKO) was produced that lack a functional IGFBP-2b and associated phe...
Peter A Doris
Peter A Doris
Adaptation to chronic hypercapnia drives time- and region-dependent changes in brainstem cardiorespiratory nuclei [0.03%]
慢性高碳酸血症适应驱动脑干心肺核团的时间和区域依赖性变化
Kirstyn J Grams,Suzanne E Neumueller,Ibrahim Y Vazirabad et al.
Kirstyn J Grams et al.
Hypercapnia occurs in numerous clinical conditions, both acutely and chronically. We previously demonstrated in healthy goats that chronic hypercapnia (CH) produced by exposure to elevated inspired CO2 leads to a sustained increase in minut...
Glen Pyle
Glen Pyle
Multiomic characterization of DNA released after airway exposure to allergens and nanoparticles reveals selective export of repetitive and fragile site DNA [0.03%]
对呼吸道暴露于过敏原和纳米颗粒后的DNA多组学特征分析揭示了重复序列DNA和不稳定的位点DNA的选择性释放
Kayla Law,Yotesawee Srisomboon,Koji Iijima et al.
Kayla Law et al.
Allergen and nanoparticle exposure generates reactive oxygen species (ROS) that endanger genome integrity, yet airway epithelial cells survive repeated exposures. Here we show that environmental allergens from Alternaria alternata and polye...
Transcriptomic Profiling Reveals Immunometabolic Gene Regulation during a 24-Hour Cold Exposure Survival Simulation in Humans [0.03%]
转录组学分析揭示人类24小时寒冷暴露存活试验中的免疫代谢基因调节规律
Jing Zhang,Shawn G Rhind,Michel B Ducharme et al.
Jing Zhang et al.
Prolonged cold exposure imposes substantial physiological and operational demands; however, the molecular mechanisms supporting human adaptation to sustained cold remain poorly defined. In this first-in-human study, we conducted genome-wide...
Regulation of RGS2 is an important piece to the puzzle of syncytiotrophoblast dysfunction in preeclampsia [0.03%]
RGS2调控是子痫前期合胞体滋养层功能障碍的重要环节之一
A Inkeri Lokki
A Inkeri Lokki
Maternal Estradiol Impacts Fetal HPA Axis and Pulmonary Transcriptomes in Sheep [0.03%]
母体雌二醇影响羊胎儿HPA轴和肺转录组
Bethania J Davila Ruiz,Wellison J S Diniz,Priyanka Banerjee et al.
Bethania J Davila Ruiz et al.
Precise coordination of parturition and fetal organ maturation is critical for neonatal survival. In sheep, a fetal cortisol surge, triggered by hypothalamic-pituitary-adrenal (HPA) axis activation, drives organ maturation and placental est...
OBESITY AS AN EPIGENETIC CONTINUUM: DEVELOPMENTAL ROOTS, ADIPOSE REMODELING, AND THE LIMITS OF REVERSIBILITY [0.03%]
肥胖是一种表观遗传连续体：发育起源、脂肪重塑及可逆性的局限性
Leon Ferder,Sebastián García Menéndez,Walter Manucha
Leon Ferder
Obesity arises from the complex interplay between genetic and epigenetic factors, with developmental programming shaping adipose fate, energy homeostasis, and treatment responses later in life. Findings from the developmental origins of hea...