Development of a predictive score for hypothermia risk during continuous kidney replacement therapy in critically ill patients [0.03%]
危重症患者连续肾脏替代治疗期间体温过低风险预测量表的构建
Panisara Chummano,Thongkran Thongkam,Naphat Chansatchanali et al.
Panisara Chummano et al.
Backgroud: Hypothermia is a frequent adverse event during continuous kidney replacement therapy (CKRT) and is associated with clinically relevant complications. However, evidence regarding its predictors remains limited. We aimed to develop...
Association of atherogenic index of plasma with urine albumin-to-creatinine ratio in Chinese urban adults: a cross-sectional study [0.03%]
中国城市成年人血浆致动脉粥样硬化指数与尿白蛋白肌酐比值的横断面研究
Yu Hou,Senyuan Chen,Qingzheng Wu et al.
Yu Hou et al.
The association between the atherogenic index of plasma (AIP) and urine albumin-to-creatinine ratio (UACR) has not been fully elucidated in large-scale populations. This study aimed to systematically examine the association between AIP and ...
tRF-1-ArgTCG-1-1 promotes renal fibrosis by regulating β-catenin [0.03%]
tRF-1-ArgTCG-1-1通过调节β-catenin促进肾纤维化
Ling Jin,Ci Wang,Yuye Yan et al.
Ling Jin et al.
Background: Renal fibrosis (RF) is a crucial pathological factor in the progression of chronic kidney disease (CKD) to end-stage renal failure. The role of noncoding RNAs (ncRNAs) in CKD has been researched recently. tRNA...
Tao Sheng,Tianhong Ma,Xin Jin et al.
Tao Sheng et al.
Background: Adenine-induced nephropathy (AIN) serves as a classic experimental model for studying uric acid-related renal injury, characterized by tubular obstruction, inflammatory cell infiltration, tubular epithelial ce...
Integrative multi-omics Mendelian randomization reveals key lipid metabolism genes as therapeutic targets for diabetic nephropathy pathogenesis [0.03%]
整合多组学孟德尔随机化揭示关键脂质代谢基因是糖尿病肾病发病机制的治疗靶点
Shan Liu,Yan Xia,Lin Ding et al.
Shan Liu et al.
Dysregulated lipid metabolism contributes to diabetic nephropathy (DN), but the genetic links remain unclear. This study identified lipid metabolism genes associated with DN risk using summary-data-based Mendelian randomization (SMR). SMR s...
Antihypertensive drugs and arteriovenous fistula flow rates among patients on maintenance hemodialysis in Egypt [0.03%]
埃及维持性血液透析患者降压药物与动静脉瘘血流量的关系
Enass Elsayed,Khaled M Kotb,Mohamed Abdel-Salam El-Awady et al.
Enass Elsayed et al.
Vascular access dysfunction is a major cause of morbidity among maintenance hemodialysis (HD) patients. Calcium channel blockers (CCBs) may affect vascular remodeling; however, their impact on arteriovenous fistula (AVF) flow rate remains u...
Combining bioinformatics and machine learning to analyze and validate sepsis-related cell senescence genes and potential drugs [0.03%]
结合生物信息学和机器学习分析并验证与脓毒症相关的细胞衰老基因和潜在药物
Shuaijie Pei,Deqiang Li,Xiaoli Yu et al.
Shuaijie Pei et al.
Sepsis is a life-threatening organ malfunction induced by the host's abnormal reaction to infection. Sepsis can induce cellular senescence, thereby exacerbating tissue damage and organ dysfunction. However, the key biomarkers of cellular se...
Prediction of acute kidney injury after total aortic arch replacement with postoperative serum lactate: a retrospective cohort study [0.03%]
术后血乳酸预测全主动脉弓置换术后急性肾损伤：一项回顾性队列研究
Xuanhe Tang,Chenxi Li,Jizhen Ren et al.
Xuanhe Tang et al.
Acute kidney injury (AKI) following total aortic arch replacement (TAAR) is linked to high morbidity and mortality, and timely identification remains a clinical challenge. While high serum lactate levels are associated with renal impairment...
Time-updated explainable machine learning predicts short-term mortality in peritoneal dialysis patients [0.03%]
基于时间更新的可解释机器学习预测腹膜透析患者的短期死亡率
Quan Wang,Yanqiong Ding,Qing Luo et al.
Quan Wang et al.
Objective: This study aimed to develop and validate a time-updated, explainable machine learning (ML) early-warning system for short-term mortality risk in patients with continuous ambulatory peritoneal dialysis (CAPD). Methods: Multiple su...
Bufalin post-transcriptionally suppresses STAT3 to alleviate renal ferroptosis and tubulointerstitial fibrosis in diabetic kidney disease [0.03%]
bufalin通过抑制STAT3的表达减轻糖尿病肾脏疾病的肾细胞铁死亡及小管间质纤维化作用研究
Yunyang Qiao,Chen Gao,Jialing Ji et al.
Yunyang Qiao et al.
The pathological hallmark of diabetic kidney disease (DKD) is tubulointerstitial fibrosis (TIF), which arises from extracellular matrix (ECM) synthesis in renal tubular epithelial cells (RTECs). Bufalin has the potential in delaying the pro...