Pregnane X receptor mitigates aristolochic acid-induced acute kidney injury via p53 ubiquitination [0.03%]
孕烷X受体通过介导p53泛素化缓解马兜铃酸肾小管损伤
Qianfang Liu,Fei Deng,Anqun Chen et al.
Qianfang Liu et al.
Aristolochic acid (AA), commonly used in Chinese herbal medicine to treat various diseases, can cause acute kidney injury (AKI). The pregnane X receptor (PXR), a nuclear receptor, is involved in drug metabolism, carcinogenesis, inflammation...
Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidation [0.03%]
乳酸通过抑制PPARα信号通路和脂肪酸氧化诱导肾脂质蓄积并加重肾纤维化
Weili Wang,Yilin Gao,Yizhen Chen et al.
Weili Wang et al.
Chronic kidney disease (CKD) is characterized by renal fibrosis as its core pathological feature, and lipid metabolism disorders are a key driver of disease progression. However, the specific pathological significance of elevated lactate le...
Transcriptome and weighted gene co-expression network analysis identify hub genes and pathways in rat kidneys after deep hypothermic circulatory arrest [0.03%]
转录组和加权基因共表达网络分析鉴定深低温停循环后大鼠肾脏核心基因及通路
Lei Wang,Ziyan Lin,Yuzuo Lin et al.
Lei Wang et al.
Background: Acute kidney injury (AKI) is a frequent and severe complication following aortic dissection repair surgery that utilizes deep hypothermic circulatory arrest (DHCA). This study aimed to identify key hub genes a...
A nine-gene diagnostic model for IgA nephropathy based on multi-cohort machine learning: integrating gene expression and immunohistochemical validation [0.03%]
基于多队列机器学习的IgA肾病诊断基因模型的构建及免疫组化验证
Yating Ge,Xiao Jiang,Jinlian Shu et al.
Yating Ge et al.
IgA nephropathy (IgAN) is the most common primary glomerulonephritis, requiring improved diagnostic tools. We analyzed three cohorts (GSE37460, GSE93798, and GSE115857 are internal validation cohorts) using gene set enrichment analysis on 7...
MedFusion-gP-AKI: development and multicenter validation of a machine learning fusion model for early prediction of KDIGO stage 3 acute kidney injury in critically ill traumatic cervicothoracic spinal cord injury patients [0.03%]
MedFusion-gP-AKI：开发并多中心验证一种机器学习融合模型以早期预测危重颈椎和上胸椎脊髓损伤患者出现KDIGO 3期急性肾损伤的风险
Yixi Wang,Jingjie Wang,Wenzhe Li et al.
Yixi Wang et al.
KDIGO stage-3 acute kidney injury (AKI), a life-threatening complication in critically ill patients with traumatic cervicothoracic spinal cord injury (TCTSCI), was associated with a 49.3% 60-day mortality and a median survival of 20 days in...
Multicenter Study
Renal failure. 2026 Dec;48(1):2640690. DOI:10.1080/0886022X.2026.2640690 2026
Impact of the drug-coated balloon-to-predilation balloon diameter ratio on restenosis risk in hemodialysis access: a study of nonlinear association [0.03%]
药物涂层球囊与预扩张球囊直径比例比对血液透析通路再狭窄的影响：非线性关联研究
Aiqiang Zhou,Yong Lu,Liangzhu Hu et al.
Aiqiang Zhou et al.
Background: Drug-coated balloons (DCBs) improve the patency of hemodialysis access, yet restenosis rates remain substantial. This may be partly attributable to suboptimal balloon sizing. The relationship between the ballo...
Salvianolic acid C alleviates acute kidney injury by restoring fructose-1,6-bisphosphatase 1-mediated gluconeogenesis [0.03%]
天冬酸酯C通过恢复果糖-1,6-二磷酸酶1介导的糖异生缓解急性肾损伤
Jianing Chen,Yujie Li,Peihui Zhou et al.
Jianing Chen et al.
This research was targeted to investigate the pharmacological effects and mechanisms of Salvianolic acid C (SAC), a natural compound extracted from the Chinese traditional herbal Danshen (Salviae Miltiorrhizae Radix et Rhizoma), in acute ki...
Iyad Mansour,Swetha Rani Kanduri,Muna Danial Muneeb Omar et al.
Iyad Mansour et al.
Muscle weakness, pain, and fatigue impair daily function in chronic kidney disease: a cross-sectional analysis from the I-RACE study [0.03%]
慢性肾脏病患者肌肉无力、疼痛和疲劳损害日常功能：I-RACE研究的横断面分析结果
Roseanne E Billany,Heitor S Ribeiro,Courtney J Lightfoot et al.
Roseanne E Billany et al.
Muscle dysfunction symptoms such as weakness and cramps are common in people with chronic kidney disease (CKD), but their impact on activities of daily living (ADLs) is not well understood. This study explored the association between muscle...
Negative impact of very mild volume overload on the heart function in patients on chronic hemodialysis [0.03%]
慢性血液透析患者容量超负荷对心脏功能的负面影响
Kristyna Michalickova,Jan Malik,Anna Valerianova et al.
Kristyna Michalickova et al.
Objectives: Heart failure is associated with higher mortality of hemodialysis patients. Fluid overload is a major risk factor for cardiovascular disease in these patients, but it is frequently clinically silent. The optim...
Observational Study
Renal failure. 2026 Dec;48(1):2624915. DOI:10.1080/0886022X.2026.2624915 2026