Bisphenol A exposure and its impact on childhood obesity: a molecular and genetic perspective [0.03%]
双酚A暴露及其对儿童肥胖的影响：分子和遗传学视角分析
Lili Chen,Limei Sun
Lili Chen
Childhood obesity is a growing public health concern, with emerging evidence suggesting that environmental factors like bisphenol A (BPA) exposure may contribute to its development. This study aims to elucidate the genetic and molecular mec...
Evaluation of Cymbopogon citratus (lemongrass) leaf extract: phytochemical screening, antimicrobial activities, cytotoxicity, antioxidant properties, and toxicological assessment [0.03%]
香茅叶提取物的评估：植物化学筛选，抗菌活性，细胞毒性，抗氧化性能和毒理学评估
Samuel Gadzama Ishaya,Ndah Khan,Ali B M Ali et al.
Samuel Gadzama Ishaya et al.
This study evaluates the phytochemical composition, antimicrobial activity, cytotoxicity, antioxidant potential, and toxicity profile of Cymbopogon citratus (lemongrass) leaf extract. The extract demonstrated antimicrobial activity with inh...
Subchronic oral administration of Tamoxifen in hormonally intact female rats induces dose-dependent maladaptive behavioral phenotypes [0.03%]
他莫西芬的亚慢性口服给药诱导激素完全的小鼠产生剂量依赖性的适应不良行为表型
Isabella P Klann,Bruna C W Fulco,Cristina W Nogueira
Isabella P Klann
Tamoxifen (TAM), the gold standard treatment for hormone-responsive breast cancer, is the most widely used Selective Estrogen Receptor Modulator (SERM). Based on the premise that subchronic oral administration of TAM may induce neurotoxic e...
A dive into the new psychoactive substances: a review of the use of zebrafish (Danio rerio) as an in vivo model [0.03%]
新型精神活性物质概览：作为活体模型的斑马鱼(Danio rerio)的应用综述
Leonardo Costalonga Rodrigues,Náthaly Cristine Bueno Faria Dos Santos,Isadora Locilento Denkena et al.
Leonardo Costalonga Rodrigues et al.
New psychoactive substances (NPS) are a broad category of drugs that pose public health risks and have poorly characterized pharmacological properties. Further studies are critical for risk assessment, toxicological profiling, and intoxicat...
Curcumin and quercetin can ameliorate arsenic and smokeless tobacco induced reproductive toxicity in female mice [0.03%]
姜黄素和檞皮素可以改善雌性小鼠因砷和无烟烟草引起的生殖毒性
Sweety Nath Barbhuiya,Dharmeswar Barhoi,Pubali Dey et al.
Sweety Nath Barbhuiya et al.
Arsenic contamination of ground water is a global problem. Consumption of smokeless tobacco called 'sadagura' is a common lifestyle practice in Assam, India. As a result, the population is more vulnerable to health outcomes with regard to f...
Synergistic effect of piperine on curcumin in cisplatin-induced nephrotoxicity through DNA fragmentation and cytokines gene expressions [0.03%]
胡椒碱和姜黄素联合使用对顺铂引起肾毒性的协同作用及机制研究
Sohail Hussain,Mohammad Ashafaq,Saeed Alshahrani et al.
Sohail Hussain et al.
Cisplatin (Cis) is an anticancer drug commonly used to treat solid tumors. However, because of its nephrotoxicity, its use is limited. Our goal was to evaluate the effects of curcumin (Cur) and piperine (Pip) administered separately versus ...
Co-administered chitosan and ivy leaf extract reduce deltamethrin-induced testicular toxicity [0.03%]
壳聚糖和 Ivy 叶提取物联合给药可减少联苯菊酯致睾丸毒性
Asmaa Mohammad Moawad,Fatma Shaban,Abla Abdelmeguid Attia et al.
Asmaa Mohammad Moawad et al.
Deltamethrin, a synthetic pesticide, is toxic to both mammalian and nonmammalian animal species. Despite its widespread use in agriculture, food safety, and disease vector control, it poses a threat to a variety of organisms. The current st...
Identification of the chemical constituents of Juglans regia ethanol extract by L-MS/MS and its effects on 5-FU-induced autophagy, oxidative stress, and apoptosis [0.03%]
液质联用技术结合乙醇提取核桃楸子化学成分的研究及其对5-Fu诱导的自噬、氧化应激和凋亡的影响研究
Hamit Uslu,Gözde Atila Uslu,Taha Abdulkadir Çoban et al.
Hamit Uslu et al.
5-fluorouracil (5-FU) is an important chemotherapeutic agent that has been used alone or in combination with other chemotherapeutics for years in the treatment of various malignancies. However, as with other chemotherapeutic agents, the dis...
Phenolic profile, in vitro antioxidant and safety evaluation of extract obtained from Citrus maxima Burm. Merr. seeds [0.03%]
指柑种子提取物的酚类成分、体外抗氧化及安全性研究
Arnab Sarkar,Akash De,Tanmoy Banerjee et al.
Arnab Sarkar et al.
Citrus maxima (Burm). Merr. (CM) has been extensively documented worldwide for its diversified ethno-pharmacological activities. Although the seeds have been previously evaluated for their anxiolytic, analgesic and anti-inflammatory propert...
A comprehensive review of artesunate-induced organ toxicity: mechanisms, resistance, biomarkers, and protective strategies [0.03%]
Artekin引起的器官毒性全面回顾：机制、耐药性、生物标志物和保护策略
Sudip Prasad Jena,Sabina Evan Prince
Sudip Prasad Jena
This paper provides a comprehensive analysis of artesunate (ART), highlighting its dual role as a highly effective antimalarial agent and its potential to induce organ toxicity under certain conditions, particularly with prolonged use over ...