Tert-butylhydroquinone attenuates anticancer drug paclitaxel-induced nephrotoxicity via inhibition of inflammation-mediated NF-κB/IL-6//TNF-α and modulation of oxidative stress-dependent Nrf2/caspase-3/GPX-4 signaling in rats
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Paclitaxel (PTX) is an efficacious natural product-derived anticancer agent. It exerts a remarkable disruption of nanopore microtubule dynamics, thus inducing cytotoxic effects on cancer cells. However, its drawback is associated with non-targeted healthy orga... ...
