Renoprotective effect of roflumilast against amikacin- induced nephrotoxicity: upregulation of Nrf2 signaling, inhibition of cytokines, and renal apoptosis [0.03%]
罗氟司特对庆大霉素引起的肾毒性的保护作用：Nrf2信号上调、细胞因子抑制和肾脏细胞凋亡减少
Mona A Abdel-Kareem,Medhat Taha,Magda E Ahmed et al.
Mona A Abdel-Kareem et al.
ABSTARCTAmikacin (AK), a potent aminoglycoside antibiotic, is known to induce nephrotoxicity. This study evaluated the renoprotective effects of ROF, a selective PDE4 inhibitor, against AK-induced renal injury in Wistar rats. Forty male rat...
Bisphenol A exacerbates diabetic foot ulcers through disruption of immune microenvironment and repair processes: a multi-omics analysis of environmental exposure mechanisms [0.03%]
双酚A通过破坏免疫微环境和修复过程加剧糖尿病足溃疡：环境暴露机制的多组学分析
Hanlin Zhang,Desheng Chen,Qiang Song et al.
Hanlin Zhang et al.
Bisphenol A (BPA) impairs chronic wound healing via immune dysregulation, yet its mechanisms in diabetic foot ulcers (DFU) remain unclear. This study explores BPA's molecular mechanisms in DFU and screens for antagonists. BPA targets and DF...
Mechanistic insights into chlorpyrifos-induced nephrotoxicity revealed by network toxicology and molecular docking [0.03%]
网络毒理学和分子对接揭示的氯吡rifos诱导肾毒性的机制见解
Ziyu Chen,Jialin Sheng,Xin Zhao et al.
Ziyu Chen et al.
Chlorpyrifos (CPF), a widely used organophosphorus pesticide, poses potential nephrotoxicity risks, yet its molecular mechanisms remain incompletely elucidated. This study integrated network toxicology, molecular docking, molecular dynamics...
Salicylic acid attenuates paclitaxel-induced toxicity by modulating interleukin expression: an in vivo study [0.03%]
水杨酸通过调节细胞因子表达来减轻紫杉醇诱导的毒性：体内研究
Farah Al-Najar,Shahrzad Shahbazi,Somayeh Reiisi et al.
Farah Al-Najar et al.
Paclitaxel (PAX) is an effective chemotherapeutic agent for treating various cancers but is associated with side effects such as hepatotoxicity, neurotoxicity, and myelosuppression. To mitigate these toxicities, adjunct therapies like salic...
Metformin attenuates valproic acid-induced developmental cardiotoxicity through activation of the AMPK/PGC-1α axis and restoration of mitochondrial and redox homeostasis in zebrafish embryos [0.03%]
二甲双胍通过激活AMPK/PGC-1α轴和恢复四氢生物蝶呤和氧化应激在家胚中的作用来减轻丙谷酸诱导的发育性心脏毒性
Ünsal Veli Üstündağ,Fümet Duygu Üstündağ,Neşe Ayşit
Ünsal Veli Üstündağ
Prenatal valproic acid (VPA) exposure is strongly linked to developmental cardiotoxicity, yet no targeted pharmacological countermeasure exists. Converging mechanistic evidence indicates that VPA cardiotoxicity centers on AMPK/PGC-1α suppr...
Frequently utilized food additives contribute to immune system dysfunction, chronic inflammation and oxidative stress [0.03%]
常用的食物添加剂会促进免疫系统功能障碍、慢性炎症和氧化应激
Soha Gomaa,Nourhan Mohamed,Mohamed Nassef
Soha Gomaa
Extensive safety measures for food additives focus primarily on target organ toxicity, neglecting the potential effects on oxidative stress and inflammation-related disruptions in the immune system. This study evaluated the effects of four ...
History repeats in sweet solutions: toxicological concerns and targeted recommendations following the cough syrup-linked paediatric mortalities in India [0.03%]
历史在甜溶液中重演：印度止咳糖浆致儿童死亡事件后的毒理学担忧和目标建议
K S Suhas,Kaveri M Jambagi,Swati Koli
K S Suhas
The latest episode of cough syrup-associated pediatric deaths in India linked to the reported diethylene glycol (DEG) contamination reverberates a long-standing catastrophic history from the Elixir Sulfanilamide disaster in the USA to the s...
Regulatory toxicity and safety profiling of N-acetyl-L-tryptophan with special emphasis on genotoxicity and male reproductive toxicity via intramuscular route of administration [0.03%]
N-乙酰-L-色氨酸的监管毒理学和安全特性评价（着重进行体内注射途径的致基因突变性和雄性生殖毒性研究）
Raj Kumar,Neelanshu Gaurav,Vimal Kumar et al.
Raj Kumar et al.
The present study was performed to evaluate N-acetyl-L-tryptophan (L-NAT) single-dose acute toxicity in Swiss albino mice and Sprague Dawley rats and 14-day repeated dose toxicity using Swiss albino mice and New Zealand white rabbit models....
Synthesis, in vivo, in silico toxicological evaluation, and safety assessment of novel methyl 4-amino-1,9b-dihydrochromeno[3,4-c] pyrrole-1-carboxylate [0.03%]
新型甲基4-氨基-1，9b-二氢螺并[3,4-c]吡咯-1-甲酸酯的合成、体内体外毒理学评价及安全性评估
Elizabeth A Omimakinde,Adedotun F Adesina,Chiagoziem A Otuechere et al.
Elizabeth A Omimakinde et al.
This study reports the synthesis and comprehensive evaluation of a chromene-based heteroaromatic ester, Methyl 4-Amino-1,9b-Dihydrochromeno[3,4-c] pyrrole-1-carboxylate (DCP). The compound (C13H12N2O3; MW 244.25) was obtained as a chocolate...
Amelioration of cyclophosphamide-induced myelosuppression by the methanol fraction of Talinum fruticosum [0.03%]
蔊珀花植物提取物缓解环磷酰胺所致的骨髓抑制作用
Victor Duniya Sheneni,Eleazar Chukwuemeka Anorue,Parker Elijah Joshua et al.
Victor Duniya Sheneni et al.
Bone marrow suppression is a critical clinical condition characterized by reduced production of hematopoietic cells, leading to anemia, immunodeficiency, and bleeding disorders. This study evaluated the protective and restorative effects of...