Ameliorative effects of forskolin and pinitol on ethyl methanesulfonate-induced genotoxicity in somatic and germline cells of Drosophila melanogaster [0.03%]
Forskolin和Pinitol对果蝇(Drosophila melanogaster)体细胞及生殖系细胞中亚甲基磺酸乙酯所致遗传毒性的改善作用
Tamara M Mladenović,Sanja Lj Matić
Tamara M Mladenović
Forskolin and pinitol are bioactive dietary compounds studied for several pharmacological properties. Considering their widespread therapeutic application and the limited information available regarding their genotoxic and/or antigenotoxic ...
Polystyrene microplastics induce liver toxicity and cytoskeleton alterations in female rats [0.03%]
聚苯乙烯微塑料诱导雌性大鼠肝脏毒性及细胞骨架改变
Kaouthar Kessabi,Sana Boughammoura,Latifa Knani et al.
Kaouthar Kessabi et al.
Microplastics (MPs) are emerging environmental pollutants that have received increasing attention in recent years. However, data on their potential risks to mammalian species remain limited. In this study, female rats were exposed via oral ...
Phthalate exposure and human reproductive health: an epidemiological review [0.03%]
酞酸盐暴露与人类生殖健康：流行病学研究综述
Binyu Sun,Hongbeichen Shi,Xin Liu et al.
Binyu Sun et al.
Plastics are ubiquitous in the environment and are widely used in food packaging, medicine, agriculture, construction and other sectors. However, the plasticizers they contain pose a substantial threat to environmental safety and human heal...
HIF-1α-associated transcriptional responses to chemical hypoxia in breast and liver cancer cells [0.03%]
缺氧诱导因子HIF-1α在乳腺癌和肝癌细胞中的转录调控作用及其对化学缺氧的反应机制研究
Okan Sancer,Pınar Aslan Koşar,Uğur Şahin et al.
Okan Sancer et al.
Hypoxia is a defining feature of the tumor microenvironment and a key driver of malignant progression through transcriptional reprogramming of metabolic, angiogenic, and survival pathways. In this study, hypoxia-induced molecular responses ...
Integrative analysis of NHANES, network toxicology, molecular docking, molecular dynamics, and in vitro experiments to elucidate the molecular mechanisms linking BPA to NAFLD [0.03%]
整合NHANES数据分析、网络毒理学、分子对接、分子动力学及体外实验揭示双酚A致非酒精性脂肪肝的分子机制
Junyu Xu,Juqing Deng,Ziyu Zhang et al.
Junyu Xu et al.
Bisphenol A (BPA), a ubiquitous plasticizer, has been implicated in lipid metabolic imbalance, yet its contribution to nonalcoholic fatty liver disease (NAFLD) remains incompletely understood. Here, we combined NHANES data analysis, network...
Curcumin protects SH-SY5Y cells against glutamate-induced excitotoxicity by maintaining genomic integrity and antioxidant balance [0.03%]
姜黄素通过维持基因组完整性和抗氧化平衡来保护SH-SY5Y细胞免受谷氨酸诱导的兴奋毒性侵害
Burak Tan,Seza Nur Suluhan,Oğuzhan Yaylalı et al.
Burak Tan et al.
Glutamate-induced excitotoxicity, characterized by oxidative stress and genomic instability, is a hallmark of neurodegenerative disorders. This study investigated the protective effects of curcumin against glutamate-induced excitotoxicity i...
Hao Ding,Rongxia Yu,Zhian Huang et al.
Hao Ding et al.
Construction dust is a major source of air pollution and easily causes intractable respiratory diseases such as pneumoconiosis. Dust suppressants are effective for dust control, yet most existing studies only focus on dust suppression perfo...
A 14-day repeated dose oral toxicity assessment of the aqueous-ethanolic extract of Schouwia purpurea in female Wistar albino mice [0.03%]
紫红色肖维草水乙醇提取物的14天经口重复给药毒性试验
Nader Kh Sayed,Ahmed M Sayed,Hala Z E Mohamed et al.
Nader Kh Sayed et al.
Schouwia purpurea (Family: Brassicaceae) S. purpurea is a wild medicinal plant traditionally used for treating gastrointestinal, inflammatory, and infectious disorders in arid regions of North Africa. Despite its ethnomedicinal importance, ...
Integrative computational and experimental approach identifies PTGS2 as a candidate molecular target in aristolochic acid-induced kidney injury [0.03%]
整合的计算与实验方法鉴定出PTGS2为 Aristolochic 酸肾损害的候选分子作用靶点
Heping Niu,Jiangwei Man,Ziyi Li et al.
Heping Niu et al.
Aristolochic acids (AAs) are a class of well-known nephrotoxic compounds; however, the molecular mechanisms underlying AA-induced kidney injury remain incompletely understood. This study aimed to identify potential molecular targets and exp...