Protective effects of Crataegus monogyna against cisplatin-induced liver and kidney toxicity in rats [0.03%]
Jale Akgöl,Emine Sarman,Rumeysa Çinar
Jale Akgöl
Cisplatin is a widely used chemotherapeutic drug, but its side effects, especially liver and kidney toxicity, can limit its clinical use, and these adverse effects are mainly associated with oxidative stress and inflammation. Accordingly, t...
Morin attenuates trimethyltin-induced hippocampal neurotoxicity in male rats by mitigating oxidative stress, inflammation, and apoptosis [0.03%]
MOR能够通过减轻氧化应激、炎症和细胞凋亡缓解雄性大鼠TMT诱导的海马神经毒性作用
Sevilcan Gazi,Metehan Akca,Cem Gazi et al.
Sevilcan Gazi et al.
Morin (3,5,7,2',4'-pentahydroxyflavone) is a natural flavonoid with potent antioxidant, anti-inflammatory, and neuroprotective properties. Trimethyltin (TMT) is a selective neurotoxin inducing hippocampal degeneration and cognitive deficits...
In-depth evaluation of biocompatibility of a porous titanium-zirconium binary alloy for potential bone implant [0.03%]
一种多孔Ti-Zr二元合金骨科植入体材料的生物相容性评估
Yuksel Cetin,Eyyup Murat Karakurt,Yan Huang et al.
Yuksel Cetin et al.
Titanium-Zirconium alloys have attracted significant attention as potential bone implant materials owing to their good biocompatibilities and acceptable strengths. In the present work, a Ti-20Zr (at.%) alloy with varying porosity levels was...
Role of endoplasmic reticulum stress in di(2-ethylhexyl) phthalate-induced renal toxicity and its amelioration by 4-phenylbutyric acid [0.03%]
4-苯基丁酸对增塑剂所致肾毒性的改善作用及机制研究
Mohammed Nazish Quasmi,Dinesh Dhingra,Ashok Jangra
Mohammed Nazish Quasmi
Di (2-ethylhexyl) phthalate (DEHP) is an environmental toxicant which is commonly used as plasticizer in various plastic products. While the nephrotoxic potential of DEHP has been reported, the exact molecular mechanism behind DEHP-induced ...
Boldine activates Nrf2/ARE signaling to alleviate 5-fluorouracil-induced apoptosis, oxidative stress and inflammation in liver tissue of rats [0.03%]
胆碱通过激活Nrf2/ARE信号通路缓解5-氟尿嘧啶所致大鼠肝组织细胞凋亡、氧化应激及炎症反应
Kalangiyam Divya Dharshini,Muthusethupathi Sharmila,Karthick Munusamy et al.
Kalangiyam Divya Dharshini et al.
5-Fluorouracil (5-FU) is widely used in the treatment of various solid tumors; however, its clinical use is often limited by hepatotoxicity. Boldine, an aporphine alkaloid, has been reported to possess antioxidant, anti-inflammatory, and he...
Aging MPs in aquatic ecosystems: a review on occurrence, interactions, vector effects, and ecotoxicology [0.03%]
水生生态系统中老化塑料的综述：发生、相互作用、载体效应和生态毒理学
Jia Du,Luxi Niu,Linlin Qiu et al.
Jia Du et al.
The aging process of microplastics (MPs) in aquatic ecosystems allows them to enter organisms through mechanisms such as direct ingestion, bioaccumulation, and as pollutant carriers, which can induce toxic effects. This study presents a bib...
A single oral exposure to polyethylene terephthalate microplastics causes mild metabolic and gastrointestinal disruption: dose and sex determinants [0.03%]
单次口服聚对苯二甲酸乙二醇酯微塑料导致轻度代谢和胃肠道紊乱：剂量和性别的决定因素
Ashley A Lewis,Adam Biales,Colette N Miller et al.
Ashley A Lewis et al.
Polyethylene terephthalate (PET) microplastics, derived from consumer products such as plastic bottles and clothing, are pervasive in the environment with documented detection in human arteries and brains among other tissues, although their...
Synthesis, DFT studies, and multi-target in silico evaluation of a piperidine-based sulfonohydrazide derivative against SARS-CoV-2, including toxicity analysis [0.03%]
基于哌啶的磺酰胲衍生物的合成、DFT研究及多靶标计算机辅助抗SARS-CoV-2评价（包括毒性分析）
D Rajaraman,S Sonadevi,A Dhandapani et al.
D Rajaraman et al.
A novel piperidine-based sulfonohydrazide derivative (BPMBS) was successfully synthesized and structurally characterized using FT-IR, ^1H NMR, and ^13C NMR spectroscopy. The FT-IR spectrum displayed characteristic absorption bands correspon...
The phytoestrogen equol protects mice against acetaminophen hepatotoxicity [0.03%]
植物雌激素戊四醇可保护小鼠免受对乙酰氨基酚的肝毒性损伤
Yasuhiro Masubuchi,Kazuya Tachibana,Nana Niihori
Yasuhiro Masubuchi
Female mice have been resistant to acetaminophen (APAP)-induced liver injury, demonstrating that endogenous estrogens provide hepatoprotection, and it is expected that exogenous estrogens may also provide a similar effect. In the present st...
Integrating network toxicology and molecular dynamics simulations to unveil the pathogenic mechanism of benzyl butyl phthalate in atopic dermatitis [0.03%]
整合网络毒理学和分子动力学模拟以揭示邻苯二甲酸二丁酯作用于特应性皮炎的致病机制
Rupei Chen,Xianwei Wu,Jinjin Kai et al.
Rupei Chen et al.
This research investigates the molecular mechanisms of benzyl butyl phthalate (BBP) in atopic dermatitis (AD) using network toxicology and molecular dynamics simulation. The environmental toxicity of BBP was systematically predicted and ass...