Protective potential of crocin against cadmium-induced oxidative pancreatitis and liver injury in female rats [0.03%]
藏红花素对雌性大鼠镉诱导的氧化性胰腺炎和肝损伤的保护潜力
Ghadha Ibrahim Fouad,Hanan Farouk Aly,Maha Zaki Rizk
Ghadha Ibrahim Fouad
Cadmium (Cd) is one of the most toxic heavy metals that are commonly present in the environment. Polyphenolic compounds exhibited the potential to mitigate heavy metal-induced organ toxicity. Crocin is a carotenoid compound of saffron. This...
Myricetin mitigates trifloxystrobin neurotoxicity by modulating the integrated stress response pathway and antioxidant defense in sH-SY5Y cells [0.03%]
芦丁通过调节整合应激反应通路和抗氧化防御缓解三氟醚菌唑神经毒性作用于sH-SY5Y细胞中的研究
Hanen Chaabani,Imen Ayed-Boussema,Hiba Hamdi et al.
Hanen Chaabani et al.
Trifloxystrobin (TFX) is a strobilurin fungicide that has a lipophilic nature, which allows it to accumulate in the brain. Therefore, it is crucial to investigate effective methods for preventing brain damage caused by TFX. We aimed to asse...
Toxicity of elemental selenium and selenium substances after pulmonary exposure; and environmental and occupational air concentrations: a review [0.03%]
元素硒及硒化合物肺暴露后的毒性作用；以及环境和职业空气浓度：综述
Niels Hadrup,Morten Poulsen,Gitte Ravn-Haren
Niels Hadrup
Selenium exposure via air can occur in the environment and workplace. To protect humans it is important to determine the concentrations at which different forms of selenium are toxic. We reviewed the literature on 1) selenium environmental ...
Targeting the SP1/ACSL4 axis attenuates ferroptosis in trastuzumab-induced cardiotoxicity [0.03%]
靶向SP1/ACSL4轴减轻曲妥珠单抗引起的心脏毒性的铁死亡
Qiyuan Hu,Bincheng Zhong,Yajie Zheng et al.
Qiyuan Hu et al.
Trastuzumab, a mainstay in treating HER2-positive breast, gastric, and lung cancers, inhibits tumor growth by inducing cell cycle arrest, apoptosis, and anti-angiogenesis. However, its clinical use is limited by cardiotoxicity. This study d...
Silymarin ameliorates post-weaning bisphenol A exposure-induced cardiotoxicity via suppression of TLR4/VCAM signaling in male Wistar rats [0.03%]
奶蓟素通过抑制TLR4 / VCAM信号传导缓解Wistar大鼠断奶后双酚A暴露引起的的心脏毒性
Waid Adeoye Saka,Victory Jesutoyosi Ashonibare,Rahmon Ayomide Aderoju et al.
Waid Adeoye Saka et al.
This study assessed the cardiotoxic effect of post-weaning BPA exposure and the potential ameliorative effect of silymarin on BPA-induced cardiotoxicity. Twenty-four male Wistar rats were randomized into four groups: the control, silymarin-...
Phytochemical characterization and cytogenotoxic activity of leaves of Centratherum punctatum Cass [0.03%]
Centatherum punctatum Cass叶的植化特性及细胞致毒作用研究
Ana Karla Araújo Silva,Yasmin Lorene de Alvarenga Araujo,Helena Albuquerque Barbosa et al.
Ana Karla Araújo Silva et al.
Centratherum punctatum (Asteraceae), known as Brazilian bachelor's button, is used in folk medicine to treat liver problems, intestinal discomfort, and ulcers. The study aims to characterize the ethanolic extract (EE) of C. punctatum leaves...
Exploring the toxicity mechanisms of acetyl tributyl citrate in premature ovarian insufficiency via network toxicology and molecular docking [0.03%]
利用网络毒理学和分子对接研究柠檬酸三丁酯致卵巢早衰的毒性作用机制
Xianlai Duan,Sumei Xu
Xianlai Duan
Background: Premature ovarian insufficiency (POI) is a complex disorder with diverse etiologies that profoundly impacts female fertility and overall health. Acetyl tributyl citrate (ATBC), a commonly used plasticizer in c...
Integrated network toxicology, machine learning, and bioinformatics analysis reveals sodium dehydroacetate-induced coagulation dysfunction in colorectal cancer [0.03%]
整合网络毒理学、机器学习和生物信息学分析揭示了山梨酸钠诱导的结直肠癌凝血功能障碍
Zhenzhen Yang,Cheng Chang,Liya Jiang et al.
Zhenzhen Yang et al.
Coagulation dysfunction, a common hematologic disorder with unclear pathogenesis, is influenced by environmental factors. Sodium dehydroacetate (SDA), a widely used preservative with high environmental mobility and persistence, has become a...
1,3-Dichloro-2-propanol induces testicular toxicity by altering biochemical and hormonal indices of fertility in male rats [0.03%]
1,3-二氯-2-丙醇通过改变大鼠生育生化和激素指标诱导雄性睾丸毒性
Rafiat A Ajala-Lawal,Najeeb O Aliyu,Adeseye B Adeyiga et al.
Rafiat A Ajala-Lawal et al.
1,3-Dichloro-2-propanol (1,3-DCP) is a moderately volatile organic compound with industrial applications in food and water processing, but it exhibits high reactivity with lipid-rich tissues. This study examines the effect of 1,3-DCP on rep...
MicroRNA (miR)-489-3p contributes to lipopolysaccharide-induced HK-2 cell injury by targeting RIPK4 and inactivating the β-catenin signaling [0.03%]
microRNA (miR)-489-3p通过靶向RIPK4并使β-catenin信号失活参与脂多糖诱导的HK-2细胞损伤
Zaiqin Deng,Hongping Hu,Peng Huang
Zaiqin Deng
Acute kidney injury (AKI) involves a sudden loss of renal function and is associated with high mortality. MicroRNA (miR)-489-3p may serve as a critical molecule in AKI according to previous studies. The study aimed to explore the functional...