Macrophage-Kruppel-Like Factor 6 Signaling Promotes Experimental Atherogenesis [0.03%]
巨噬细胞KLF6信号促进动脉粥样硬化炎症反应
Hang Pong Ng,Atif Zafar,Rachel Diamond-Zaluski et al.
Hang Pong Ng et al.
A hallmark event in the development of atherosclerotic plaque is the accumulation of lipid-laden macrophages in the subendothelial layers of affected blood vessels. Macrophages are key players in all stages of atherogenesis, including plaqu...
Updates on tau-related drug targets and potential disease-modifying therapies for Alzheimer's disease [0.03%]
Tau相关药物靶点及阿尔茨海默病潜在疾病修饰疗法研究进展
Anabela Djurovic-Topalovic,Natalie G Horgan,Jessica S Fortin
Anabela Djurovic-Topalovic
Alzheimer's disease (AD) is a chronic multifactorial neurodegenerative disease affecting a large proportion of the elderly population with detrimental psychological and socioeconomic impacts. This review starts with a brief overview of the ...
Novel Kinesin Family 1A Variants Linked to Atypical Parkinsonism Elicit Altered Neuronal TDP-43 Interactions and Dendritic Atrophy [0.03%]
新型动力蛋白家族1A变异体与非典型帕金森病相关的新型动力蛋白家族1A变异体导致神经元TDP-43相互作用改变和树突萎缩
Houman Homayoun,Michael R DeChellis-Marks,Julia Kofler et al.
Houman Homayoun et al.
Analysis of iPSC-derived neurons from the son of a father-son pair with novel familial Variants of Uncertain Significance in KIF1A [c.408C>G (p.Asp136Glu); c.3914G>A (p.Arg1305His)] reveal pathological features of altered TDP-43 localizatio...
Cross-Species Functional Genomic Screens Identify Novel Therapeutic Targets in Malignant Peripheral Nerve Sheath Tumors [0.03%]
跨物种功能基因组学筛选鉴定出恶性外周神经鞘瘤的新治疗靶点
Brittany Turner-Ivey,Amanda M Prechtl,Stephen T Guest et al.
Brittany Turner-Ivey et al.
As oncogenic pathways are highly conserved in vertebrates, genetically engineered mouse models can potentially be used to identify therapeutic targets relevant to rare human cancers such as malignant peripheral nerve sheath tumors (MPNSTs)....
HIF-1α-induced astrocytic D-dopachrome tautomerase activates microglial inflammatory response following spinal cord injury [0.03%]
脊髓损伤后HIF-1α诱导的星形胶质细胞D-多巴醌异构酶激活小胶质细胞炎症反应
Aicheng Li,Mengdi Li,Si Xu et al.
Aicheng Li et al.
Spinal cord injury (SCI) often results in severe hypoxia and excessive activation of neuroinflammation, which aggravates neuropathology and neurological dysfunction. D-dopachrome tautomerase (D-DT), the homolog of macrophage migration inhib...
Distinct Role of Dural and Leptomeningeal Macrophages in Maintaining Cerebrospinal Fluid Drainage to Meningeal Lymphatic Vessels [0.03%]
颅骨和蛛网膜巨噬细胞在维持脑脊液到蛛网膜淋巴管引流中的不同作用
Vikrim Lohat,Raffay Ilyas,Qing Wei et al.
Vikrim Lohat et al.
Cerebrospinal fluid (CSF) drains along the perivascular space, known as the glymphatic system, to the meninges, where meningeal lymphatic vessels (MLVs) remove toxic products with excess CSF from the brain. Macrophages are widely present in...
Perilipin 2 mediates progression of lung adenocarcinoma by modulating lipid metabolism [0.03%]
perilipin 2通过调节脂质代谢促进肺腺癌进展
Kana Miyata-Morita,Akira Kawashima,Mitsuo Kiriya et al.
Kana Miyata-Morita et al.
Perilipin 2 expression is related to poor prognosis of patients with various malignant tumors. Perilipin 2 exists on the surface of lipid droplets (LDs), which store lipids that can be used as an energy source during cancer progression. How...
Identification of pre-clinical biomarkers of MASLD vs MetALD and the impact of diet [0.03%]
MASLD与MetALD的临床前生物标志物识别以及饮食的影响
Tyler C Gripshover,Rui S Treves,Josiah E Hardesty
Tyler C Gripshover
Recent diagnostic advancements have characterized MASLD and increased alcohol intake (MetALD) if alcohol consumption is ≥20 or 30 grams/day, females and males, respectively. Available treatments may affect dietary behavior or treat organ p...
Burhan Yokus,Luca Maccioni,Lihong Fu et al.
Burhan Yokus et al.
Alcohol consumption contributes to systemic organ dysfunction, but its direct effect on kidney health is unclear. Epidemiological studies show inconsistent findings due to reliance on conventional markers like serum creatinine (sCr) and blo...