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HIF-1α-induced astrocytic D-dopachrome tautomerase activates microglial inflammatory response following spinal cord injury

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Spinal cord injury (SCI) often results in severe hypoxia and excessive activation of neuroinflammation, which aggravates neuropathology and neurological dysfunction. D-dopachrome tautomerase (D-DT), the homolog of macrophage migration inhibitory factor (MIF), ... ...