NASH exacerbates inflammatory bone destruction and macrophage NLRP3 inflammasome activation in ligature-induced periodontitis [0.03%]
NASH加剧线扎诱导的牙周炎中骨破坏和巨噬细胞NLRP3炎症小体活化
Zijun Wang,Xiaoyue Sun,ZhaoJun Chen et al.
Zijun Wang et al.
Metabolic disorders and accompanying complications pose considerable risks to systemic organ health. Clinical studies have revealed a significant correlation between non-alcoholic steatohepatitis (NASH) and increased severity of periodontit...
PathViT: Automated disease classification from skeletal muscle histopathology [0.03%]
基于骨骼肌组织病理图像的自动疾病分类方法 PathViT
Taymaz Akan,Sait Alp,Richa Aishwarya et al.
Taymaz Akan et al.
Analyzing skeletal muscle pathology from histological images is a labor-intensive process prone to inter- and intra-user variability influencing diagnosis accuracy and consistency-conventional techniques, such as ImageJ-based tools, demand ...
Microglia promote neurodegeneration and hyperkatifeia during withdrawal and abstinence from binge alcohol [0.03%]
小胶质细胞促进间歇性过量饮酒后戒断和停酒期间的神经退行性和hyperkatifeia现象
Elizabeth M McNair,Lamar W Dawkins,Baylee Materia et al.
Elizabeth M McNair et al.
Proinflammatory microglial polarization, neuronal death, and hyperkatifeia/negative affect during withdrawal are key features of alcohol use disorder (AUD). However, the role microglia play in the development of AUD-related neuronal and beh...
Kyle Yuquimpo,Janice Averilla,Zhuan Li et al.
Kyle Yuquimpo et al.
Liver macrophages consist of both Kupffer cells (KCs) and infiltrating macrophages (IM), and both populations change during alcohol associated liver disease. It has been suggested that KCs undergo a pro-inflammatory change after alcohol exp...
PGE2 signaling triggers CD31-independent transendothelial migration in vitro and in vivo [0.03%]
PGE2信号触发体外和体内CD31非依赖性跨内皮迁移
Vanessa Hayashi,Michael A Seidman,William A Muller
Vanessa Hayashi
Genetic deletion or antibody blockade of platelet endothelial cell adhesion molecule-1 (CD31, PECAM) inhibits transendothelial migration (TEM) of leukocytes in all mouse strains studied except C57BL/6. A prior publication showed that this p...
Improving Colorectal Cancer Screening and Risk Assessment through Predictive Modeling on Medical Images and Records [0.03%]
基于医学影像和病例记录的预测模型在改善结直肠癌筛查和风险评估中的作用
Shuai Jiang,Christina Robinson,Joseph Anderson et al.
Shuai Jiang et al.
Colonoscopy screening effectively identifies and removes polyps before they progress to colorectal cancer (CRC), but current follow-up guidelines rely primarily on histopathological features, overlooking other important CRC risk factors. Va...
Transforming Growth Factor-β Signaling in Alcohol-Associated Liver Disease: A Multicellular Perspective [0.03%]
酒精相关性肝病的转化生长因子-β信号通路：多细胞角度透视
Huihui Zou,Sai Wang,Chenjun Huang et al.
Huihui Zou et al.
Transforming growth factor-β (TGF-β) signaling exerts broad regulatory n effects on alcohol-associated liver disease (ALD) progression influencing processes such as hepatocellular injury, regeneration, inflammation, fibrogenesis, cirrhosi...
Inactivation of Atp7b copper transporter in intestinal epithelial cells is associated with altered lipid processing and cell growth machinery independent from hepatic copper accumulation and severity of liver histology [0.03%]
肠上皮细胞中的Atp7b铜转运蛋白失活与肠道脂质处理和细胞生长机制的改变有关，独立于肝铜积累和肝脏组织学严重程度的影响
Amanda Caceres,Noreene M Shibata,Christian D Davalos-Gutierrez et al.
Amanda Caceres et al.
The clinical manifestations of Wilson disease (WD) are related to copper accumulation in the liver and brain, but little is known about the role of other organs expressing the ATP7B copper transporter on metabolic and ultrastructural change...
Specialized pro-resolving mediators MaR1 and LXA4 resolve inflammation during acute chemical lung injury in the absence of neutrophils [0.03%]
中性粒细胞缺失情况下，专业解决介质MaR1和LXA4在急性化学性肺损伤过程中促进炎症消退
Maureen E Haynes,Vivienne Fang,Meital Gewirtz et al.
Maureen E Haynes et al.
Gastric aspiration pneumonia involves chemical injury to the alveoli of the lungs with inflammation, tissue damage, and recruitment of polymorphonuclear leukocytes (PMNs). PMNs are also known to be involved in the production of specialized ...
Intra-host genomic variation of Haemophilus influenzae isolates from asymptomatic nasopharyngeal carriers involves genes encoding proteins with diverse inferred functions [0.03%]
无症状鼻咽携带者中流感嗜血杆菌分离株的宿主内基因组变异涉及编码多种推测功能蛋白质的基因
Randall J Olsen,S Wesley Long,Yuvanesh Vedaraju et al.
Randall J Olsen et al.
Haemophilus influenzae is a human-specific pathogen that causes infections ranging in severity from otitis media to potentially fatal meningitis. It also asymptomatically colonizes the upper respiratory tract. Although intra-host genomic va...