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PGE2 signaling triggers CD31-independent transendothelial migration in vitro and in vivo

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Genetic deletion or antibody blockade of platelet endothelial cell adhesion molecule-1 (CD31, PECAM) inhibits transendothelial migration (TEM) of leukocytes in all mouse strains studied except C57BL/6. A prior publication showed that this phenotype maps to a s... ...