Zincke-Imine-Based Peripheral Editing of 2-Arylpyridines to Access 3-Acylpyridines [0.03%]
基于Zincke亚胺的外周编辑合成3-酰基吡啶类化合物
Piotr Banachowicz,Antoni Powala,Kitti Szabó et al.
Piotr Banachowicz et al.
Skeletal and peripheral editing of pyridines is a powerful strategy for the late-stage functionalization of N-heterocycles. While pyridines inherently exhibit high reactivity at the C2 and C4 positions, functionalization at the C3 position ...
Direct Assembly of Privileged α-CF3 Allylamines via Photoinduced Pd-Catalyzed C-H Aminoalkylation of Alkenes [0.03%]
光诱导Pd催化烯烃的C-H氨基烷基化直接构建 privileged α-CF3亚胺类化合物
Jie Zhou,Lu-Ping Hu,Xuan Fan et al.
Jie Zhou et al.
α-CF3 allylamines are valuable scaffolds in pharmaceuticals, agrochemicals, and materials science, yet efficient synthetic methods remain scarce. Herein, we report a photoinduced palladium-catalyzed C-H aminoalkylation of alkenes for the d...
Photoinduced Cleavage of Alkenyl Fluorides for Nucleophilic Acyl Substitution via In Situ Generated Acyl Fluorides [0.03%]
原位生成的酰氟参与的亲核酰基取代反应研究及光促烯基氟化物的断裂反应研究
Emma S Gogarnoiu,Melissa S Griffin,Ajay H Bansode et al.
Emma S Gogarnoiu et al.
Acyl fluorides are valuable intermediates due to their stability and unique reactivity with amines, enabling selective acyl substitution. We report a mild one-pot method to access amides, esters, and thioesters from alkenyl fluorides. Visib...
Trifluoromethylation of Arenes and Heterocycles via a Bench-Stable Photocaged Trifluoromethylation Reagent [0.03%]
通过适用于实验台的光罩三氟甲基化试剂实现芳烃和杂环的三氟甲基化
Gavin J Rustin,Vishal Agarwal,Penelope I Dalton et al.
Gavin J Rustin et al.
Herein we report a simple radical aromatic trifluoromethylation process that utilizes a cationic aromatic sulfonate ester as a trifluoromethyl radical photocage. This chemistry allows for the rapid and straightforward trifluoromethylation o...
Nickel-Catalyzed Desulfurizative Sonogashira Cross-Coupling of Terminal Alkynes with Alkenylsulfonium Salts [0.03%]
镍催化末端炔烃与烯基磺𬭩盐的脱硫sonian催耦反应
Mengke Su,Xiaoyu Li,Mingchuan Zhang et al.
Mengke Su et al.
A new protocol for C(sp2)-C(sp) bond formation via the nickel-catalyzed desulfurizative Sonogashira cross-coupling reaction involving C(sp2)-S bond cleavage with alkenylsulfonium salts as an electrophilic coupling partner is described. The ...
Copper-Catalyzed (5+1) Annulation of Imidazolidines with Cyclopropenes: Synthesis of Functionalized 2-Vinylpiperazines [0.03%]
铜催化imidazolidine与环丙烯的(5+1)环化反应：功能化2-乙烯基哌嗪合成
Xiaoai Liu,Yu Xiong,Haiyang Wang et al.
Xiaoai Liu et al.
Herein, we report a copper-catalyzed (5+1) annulation between imidazolidines and cyclopropenes, providing a modular, atom-economical, and efficient strategy for the synthesis of diverse functionalized 2-vinylpiperazines in moderate to good ...
Resonance-Enhanced Excited-State Intramolecular Proton Transfer Emission by Base-Mediated Formation of α-Cyano-γ-lactone [0.03%]
通过碱介导形成α-氰基-γ-内酯增强的激发态分子内质子转移发射共振
Théo Andris,Timothée Stoerkler,Gilles Ulrich et al.
Théo Andris et al.
This letter describes the synthesis and structural, photophysical, and theoretical properties of novel fluorescent dyes derived from 2-(2'-hydroxyphenyl)benzoxazole, functionalized by tricyanofuran or α-cyano-γ-lactone groups, prone to un...
Mechanistic Insights into Aerobic C(sp3)-H Hydroxylation: A Catalytic Reaction or Not [0.03%]
关于氧化C-H羟基化反应的机制见解：是一种催化反应吗？
Changming Li,Zengwei Wang,Qian Peng
Changming Li
The mechanism of aerobic C(sp3)-H hydroxylation to α-hydroxy ketone is investigated by multiple quantum chemical computations. An alkali-metal-assisted electron transfer (AET) is proposed to drive the triplet-to-singlet transition for C-O ...
Diversity-Oriented Enzymatic Modular Synthesis of N-Glycans Bearing LacdiNAc-Related Epitopes [0.03%]
一种基于酶的模块化合成带有LacdiNAc相关决定簇的N-糖链的多样性导向方法
Xuefei Yin,Xiaoying Zhang,Kan Zhong et al.
Xuefei Yin et al.
The disaccharide unit GalNAcβ1,4GlcNAc (LacdiNAc or LDN) and its α1,3-fucosylated derivative LDNF and α2,6-sialylated derivative 6'-SLDN are common epitopes of various N-glycans. Due to their structural complexity, the synthesis of a com...
A Synthetic Approach to Diverse Indole/Oxindole-Annulated S-Heterocycles [0.03%]
合成构建多样的含吲哚/氧吲哚硫杂环化合物的新方法
Yongqiang Xu,Shen-Yuan Zhang,Jingping Qu et al.
Yongqiang Xu et al.
The research for developing efficient and practical strategies to access sulfur-containing medium-sized rings is of great interest, yet remains elusive and challenging. Herein, we describe a versatile strategy enabling the facile constructi...