Ti-Promoted Pd- and Fe-Catalyzed Regiodivergent C-H Arylation of Pyridines [0.03%]
钛促进的吡啶C-H芳基化区域选择性转换PidininesRegioselective C-H Arylation of Pyridines with Palladium and Iron Catalysis Promoted by Titanium
Xiao-Di Ma,Jing-Yan Kong,Jun-Ting Li et al.
Xiao-Di Ma et al.
We report a practical, regiodivergent C-H arylation of pyridines. In the presence of Ti-1·2(TMPMgCl·LiCl), diverse 2- or 3-substituted pyridines undergo Pd-catalyzed C6-H arylation under mild conditions, overriding the classical ortho-dir...
A Palladium-Catalyzed Cascade Process of 1,3-Enynes and Imines to Construct Multisubstituted Pyrrole Derivatives [0.03%]
钯催化1,3-炔烯和亚胺构建多取代吡咯化合物的级联反应
Tian-Ying Zhang,Bao-Rui Kong,Ze-Liang He et al.
Tian-Ying Zhang et al.
A palladium-catalyzed cascade reaction of 1,3-enynes and aldimines to efficiently access multisubstituted pyrroles is reported, proceeding in a Pd(0) π-Lewis base-mediated vinylogous addition, intramolecular central carbon N-allylation of ...
Synthesis of Fused Azole-Pyridazine/Pyrimidine and Imino-Bridged Pyrazole-Based Energetic Materials via Property Tuning and Skeletal Editing [0.03%]
基于性质调控与骨架重排的杂环含能材料的合成
Pengzhao Han,Jie Sun,Wei Du et al.
Pengzhao Han et al.
Imino-bridged energetic materials constitute a significant branch in the advancement of nitrogen-rich heterocycles. Nevertheless, skeletal editing strategies have yet to be successfully employed in the synthesis of these functionalized arch...
Cobalt-Catalyzed Borylation of Arenes Enabled by in Situ π-Coordination [0.03%]
原位π配合催化芳烃硼化的反应性及机理研究
Akash G Tathe,Yuichiro Mutoh,Laurean Ilies
Akash G Tathe
π-Coordination of an arene to chromium enables cobalt-catalyzed C-H borylation with a simple catalytic system consisting of commercially available compounds, [Co(acac)2] and a terpyridine derivative. Arenes can be directly borylated via in...
Visible-Light-Induced Defluorinative Giese Reaction of gem-Difluorides via the ConPET Process: A Route to tert-Alkyl Fluorides [0.03%]
通过ConPET过程光诱导gem-二氟化物的脱氟GEISE反应：制备叔烷基氟化物的新方法
Hong Xin,Zi-Hang Yuan,Shutao Wang et al.
Hong Xin et al.
The activation of C(sp3)-F bonds, particularly the selective activation of polyfluorinated compounds, is an important yet challenging topic in organic synthesis. Herein, we report a metal-free, visible-light-induced defluorinative Giese rea...
Mechanistic and Kinetic Studies of Reductions of α,β Unsaturated Esters and Ketones by SmI2-Water [0.03%]
SmI2-水对α,β不饱和酯和酮的还原反应的动力学及机理研究
Jonathan B Hixson-Cooper,Robert A Flowers nd
Jonathan B Hixson-Cooper
The coupling of ketones with activated olefins is an important class of reactions that has been widely proposed to undergo initial reduction of the ketone, followed by radical addition of the intermediate ketyl to the olefin. In an initial ...
Shuttle Hydrogen Atom Transfer for Hydro-Fluorosulfonylation of Haloalkynes without β-Scission [0.03%]
无需β断键的 haloalkyne 氢氟磺酰化氢原子转移反应研究
Tianyu He,Yi Duan,Qixin Jia et al.
Tianyu He et al.
Radical addition to haloalkynes often produces alkynylation products with the cleavage of these halogen groups. Herein, we report a direct hydrogen atom transfer (d-HAT) photocatalysis-enabled shuttle HAT system that realizes hydro-fluorosu...
Breaking the Scalability Barrier: Diversifiable Pd-Catalyzed Domino Reaction En Route to Dibenzo[ b,d]azepines [0.03%]
突破限制：通向二苯并[b,d]氮杂卓的可分散Pd催化的级联反应
Ruoqian Fan,Yaohuang Huang,Lingchao Cai et al.
Ruoqian Fan et al.
Herein, we present an efficient synthesis of diverse dibenzo[b,d]azepines in high yields via Pd-catalyzed domino reactions of 2,2'-dihalobiphenyls with N-allyl alkylamines. The key to this success is in situ generation of a five-membered, c...
Rh(III)-Catalyzed Strain-Release-Enabled C-H Alkenylation/[4+1] Annulation of Benzamides with Alkylidenecyclobutanes [0.03%]
Rh(III)催化环张力释放苯甲酰胺与亚甲基环丁烷的C(sp2)-H烯基化/[4+1]环化反应
Xin-Xing Liu,Yuan-Jie Meng,Zi-Feng Yang et al.
Xin-Xing Liu et al.
A Rh(III)-catalyzed strain-release-enabled C-H alkenylation/[4+1] annulation of benzamides with alkylidenecyclobutanes is described, enabling the efficient construction of 3-methyleneisoindolin-1-one derivatives. This protocol uniquely inte...
Rhodium-Catalyzed O-H Insertion Reactions to (2-Diazo-1,1,3,3,3-pentafluoropropyl)phosphonate: A Convenient Route to Fluorinated β-Alkoxy Vinylphosphonates [0.03%]
铑催化O-H插入反应至(2-叠氮-1,1,3,3,3-五氟丙基)膦酸酯：制备氟代β-烷氧乙烯基膦酸酯的便捷方法
Ita Hajdin,Romana Pajkert,Haibo Mei et al.
Ita Hajdin et al.
The rhodium(II)-catalyzed insertion of benzyl and alkyl alcohols with 2-diazo-1,1,3,3,3-pentafluoropropylphosphonate unexpectedly afforded fluorinated β-alkoxy vinylphosphonates. The reaction proceeds under mild conditions and shows broad ...