Visible-Light-Induced [5 + 1] Annulation of Vinyl Cyclopropane with Nitrene [0.03%]
乙烯基环丙烷与氮烯的可见光诱导[5+1]环化反应
Shalu Deshwal,Janakiram Vaitla
Shalu Deshwal
A metal- and reagent-free visible-light-mediated [5 + 1] annulation of vinyl cyclopropanes with iminoiodinanes has been developed, providing efficient access to 1,2,3,6-tetrahydropyridines with broad substrate tolerance for aryl, alkyl, and...
Decarboxylative Redox Bicyclo[1.1.1]pentylation: Benchmarking the Influence of Backbone Substituents on C-C Bond-Forming Reactions [0.03%]
脱羧氧化还原并环[1.1.1]戊烷化反应：背骨取代基对C-C键形成反应影响的评测研究
Stacie K Nelson,Austin Pounder,Alexandra E Thwaites et al.
Stacie K Nelson et al.
The allylic substitution of α-(trifluoromethyl)styrenes was used to assess the feasibility of C-C bond formation to the bridgehead of bicyclo[1.1.1]pentanes via redox-active esters that fragment upon single-electron reduction. We observed ...
Cyclopropanation of Alkenes with Dichloromethane and Chloroform via Halogen Atom Transfer Using Amine Carboxyborane [0.03%]
通过胺羧基硼烷介导的卤原子转移使二氯甲烷和氯仿与烯烃环丙烷化反应
Changhee Park,Sunggi Lee
Changhee Park
Cyclopropanes are privileged motifs in medicinal chemistry due to their role as bioisosteres of arenes, alkenes, and small alkyl groups. Herein, we report a transition-metal-free, photoredox-catalyzed cyclopropanation of diverse alkenes via...
An Umpolung Strategy for Palladium-Catalyzed Dearomative Allylation toward Eight-Membered N-Heterocycles [0.03%]
钯催化去芳构化烯丙基化反应构建八元氮杂环的 umpolung 策略
Sumin Lee,Sekwang Baek,Yongho Kim et al.
Sumin Lee et al.
In this study, umpolung palladium catalysis was developed for achieving 1,2-dearomative allylation followed by intramolecular cyclization. The dearomatization involves activated N-arenes and the in situ generated nucleophilic η1-allyl-pall...
Tf2O-Mediated Phospha-Michael Addition to Unactivated α,β-Unsaturated Amides [0.03%]
经Tf2O介导的未活化α,β-不饱和酰胺的膦迈克尔加成反应
Ranran Zhu,Tingting Xie,Yirui Shen et al.
Ranran Zhu et al.
Tf2O-mediated phospha-Michael addition to unactivated α,β-unsaturated amides has been developed under mild, metal-free conditions, providing efficient access to γ-aminophosphine oxides with excellent regioselectivity. This protocol featu...
Practical Post-Functionalizable Iodosulfonylation of Allenes for Integrating Multifunctional Molecules [0.03%]
用于集成多功能分子的全烯碘磺酰化的新方法
Shijie Liu,Dan Cheng,Chuxiong Peng et al.
Shijie Liu et al.
Herein, we report a post-functionalizable iodosulfonylation of allenes that enables modular synthesis of multifunctional molecules. This transformation proceeds under mild, additive-free, and transition-metal-free conditions in aqueous medi...
Iron-Catalyzed Alkylation-Reduction of N-Methyl Nitrones via LMCT Activation [0.03%]
铁催化N-甲基硝酮的LMCT活化烯丙基烷基化-还原反应
Renan de O Gonçalves,Jeimy A C Vélez,Natalí P Debia et al.
Renan de O Gonçalves et al.
N-Monomethyl secondary amines are privileged structural motifs that frequently occur in pharmaceuticals and bioactive molecules. However, their synthesis often requires harsh conditions or suffers from poor selectivity. Here, we report a re...
Copper-Catalyzed Asymmetric Allyl Addition of Imines with Allenylsilanes [0.03%]
铜催化亚胺与烯丙基硅烷的不对称烯丙基加成反应
Chi Yang,Menghua Xu,Aijun Lin et al.
Chi Yang et al.
A copper-catalyzed allylation of N-tert-butanesulfinyl imines with silylallenes has been developed, affording chiral homoallylic amines bearing multiple stereocenters with excellent stereocontrol. The protocol features mild conditions, broa...
Dual Anomeric Stereocontrol in 1,1'-Glycosylation via a Remote Directing 2-(Diphenylphosphinoyl)acetyl Group [0.03%]
远程导向基团在1,1'-糖基化反应中实现 anomeric立体选择性控制
Xin Huang,Keyu Wang,Zhaolun Zhang et al.
Xin Huang et al.
The stereoselective construction of 1,1'-glycosidic linkages represents a significant challenge, as it typically results in a mixture of four possible anomers. Herein, we report a novel and efficient method to achieve this transformation le...
Synthesis of Multisubstituted Pyridines by Heterocyclization of TosMIC Derivatives: Total Synthesis of Caerulomycins A and K [0.03%]
托斯甲基氰衍生物的杂环化合成多元取代吡啶：石蕊菌素A和K的全合成
José A García-García,José Luis Aceña,Patricia García-García et al.
José A García-García et al.
A concise synthesis of multisubstituted pyridines from α-allylic TosMIC derivatives and electrophiles is reported. The process involves a tandem heterocyclization exploiting the dual reactivity of the isocyanide group. The methodology tole...