Photochemical, Catalyst-Free [2+2] Cycloaddition of Coumarin-3-carboxylates with Alkenes [0.03%]
无催化剂参与的香豆素-3-羧酸酯与烯烃的光化学[2+2]环加成反应
Parashuram Sharma,Nisha Rawat,Seshadri Reddy Nasireddy et al.
Parashuram Sharma et al.
Herein, we report a visible light-promoted, photocatalyst-free [2+2] photocycloaddition of coumarin-3-carboxylates with alkenes, resulting in an expeditious and efficient synthesis of cyclobutane-fused coumarins. The reaction was demonstrat...
Acid-Catalyzed Dehydrative Nucleophilic Substitutions of 2,6-Di(hydroxymethyl) BODIPYs: A Platform for BODIPY Functionalization [0.03%]
用于BODIPY功能化的脱水亲核取代反应平台：酸催化2,6-二-(羟甲基)BODIPY的去hydrative核置换反应
Clara Uriel,Alberto Hernández,Natalia Casado et al.
Clara Uriel et al.
We report the synthesis of the novel 2,6-di(hydroxymethyl)-1,3,5,7-tetramethyl-8-phenyl BODIPY and its utility in efficient Lewis-acid-catalyzed dehydrative nucleophilic substitution reactions. This diol, readily prepared via a formylation/...
Nickel-Catalyzed Decyanative Reductive Coupling of Benzyl Nitriles with Aryl Chlorides toward the Synthesis of Diarylmethanes [0.03%]
镍催化苯甲腈和芳基氯的去腈还原偶联反应制 diarylmethanes 烷烃合成研究
Xianmao Liu,Qian Ni,Yaqi Chen et al.
Xianmao Liu et al.
Herein, nickel-catalyzed decyanative reductive cross-coupling of benzyl nitriles with aryl chlorides has been developed. The current protocol features a wide scope, good functional group compatibility, and excellent chemoselectivity, thus p...
Sodium Hypophosphite Assisted Ruthenium Catalyzed Reductive Amination under Mild Conditions [0.03%]
低温下RU催化氢磷酸钠辅助的还原胺化反应
Olesya Zvereva,Fedor S Kliuev,Natalia Lebedeva et al.
Olesya Zvereva et al.
We report a catalytic method for reductive amination using sodium hypophosphite as a cheap, bulk-grade available, and environmentally friendly reductant. The use of CpRu(PPh3)2Cl allowed the reaction to proceed under mild conditions, afford...
Photoredox-Catalyzed Strain-Release-Driven Aminopyridylation of Bicyclo[1.1.0]butanes with N-Aminopyridinium Ylides [0.03%]
光氧化还原催化下N-氨基吡啶
Hai-Xiang Gao,Yuanhang Li,Mengyu Wu et al.
Hai-Xiang Gao et al.
An unprecedented visible-light-induced strain-release-driven aminopyridylation of bicyclo[1.1.0]butanes with bench-stable and easily accessible N-aminopyridinium ylides was developed. The photoredox-catalyzed transformation proceeds through...
Enantioselective Synthesis of Boron-Stereogenic Heterocycles Enabled by Asymmetric Nickel Catalysis [0.03%]
手性镍催化不对称合成含硼手性杂环化合物
Bin Ma,Xinyue Tang,Xin Zhou et al.
Bin Ma et al.
Despite the widespread utilization of organoboron compounds across various areas, the efficient construction of stable and enantioenriched boron-centered chiral molecules remains a persistent challenge. Here, we present a nickel-catalyzed s...
Cosolvent Effects Question the Role of Water in Native Chemical Ligation [0.03%]
共溶剂效应质疑原生化学连接中的水的作用
Julie Di Adamo,Vangelis Agouridas,Vincent Diemer et al.
Julie Di Adamo et al.
Guanidine hydrochloride and acetonitrile strongly inhibit native chemical ligation (NCL). These effects, considered alongside the impact of the cosolvents on the water structure, suggest that water actively participates in NCL.
Redox-Neutral Radical Annulation of Challenging Alkynes with Aryl Sulfoxonium Ylides for 1-Naphthol Synthesis [0.03%]
用于1-萘酚合成的具有挑战性的炔烃与芳基硫
Hongyin Huang,Yilian Lu,Mengqi Gui et al.
Hongyin Huang et al.
This radical strategy represents the first use of sulfoxonium ylide-derived radicals in 1-naphthol synthesis and overcomes the substrate limitations of classical carbene-based methods. It enables annulation of unactivated terminal alkynes─...
Visible Light-Mediated Thia-Paternò-Büchi Reaction of Indoles through Energy Transfer: Synthesis of Thietane-Fused Polycyclic Indolines [0.03%]
通过能量转移介导的可见光诱导的吲哚硫化Patiño-Büchi反应：噻坦稠环并多氢吲哚的合成
Xixiang Yu,Jianjian Huang,Tengfei Pang et al.
Xixiang Yu et al.
The thia-Paternò-Büchi reactions represent a valuable yet underexploited transformation compared to analogous [2+2] photocycloadditions involving olefins, carbonyls, and imines. Herein, we present visible light thia-Paternò-Büchi reacti...
Transient Directing Group Enabled Nickel-Catalyzed Satoh-Miura Annulation of Free Benzylamines with Alkynes [0.03%]
瞬时导向基团控制的镍催化自由苯胺与炔烃的Satoh-Miura环化反应
Chen Ma,Jinlong Liu,Ying Kang et al.
Chen Ma et al.
We report a nickel-catalyzed Satoh-Miura annulation of free benzylamines with alkynes, enabled by a transient directing group (TDG) strategy. The integration of the TDG approach with earth-abundant nickel catalysis provides a straightforwar...