Ru(II)-Catalyzed Divergent C-H Annulations of Propargyl Cyclic Carbonates [0.03%]
Ru(II)催化丙炔基环碳酸酯的多样性C-H官能团化反应
Debasish Jana,Geetanjali S Sontakke,Chandra M R Volla
Debasish Jana
Herein, we report Ru(II)-catalyzed divergent annulations of propargyl cyclic carbonates with arylpyrazolidinones via C-H bond activation. The combination of base and solvent was pivotal in dictating the reaction pathway, enabling selective ...
Photoredox/Nickel Dual-Catalyzed Asymmetric C-Alkylation of Nitroalkanes with α-Bromoketones [0.03%]
光氧化还原/镍双催化硝基烷烃与α-溴酮的不对称C-烯丙基化反应
Sina Rezazadeh,Raphael S Kim,Donald A Watson
Sina Rezazadeh
A stereoselective method for alkylating nitroalkanes with α-bromoketones using nickel/photoredox dual catalysis is described. The mild and functional-group-tolerant conditions allow the formation of complex and highly enantioenriched β-ni...
Biosynthesis of Waspergillamide A Involves Unclustered Genes and a depsi-Tetrapeptide Diketopiperazine-Forming NRPS [0.03%]
羽网菌素A生物合成涉及未结合作基因和形成depsi-四肽二酮哌嗪的NRPS
Xian-Liang Zeng,Wencong Yang,Yi-Fan Du et al.
Xian-Liang Zeng et al.
Comparative genomics identified a nonribosomal peptide synthetase gene cluster (wpa), spanning two genomic scaffolds, responsible for waspergillamide A (1) in Aspergillus sp. CMB-W031. Pathway reconstitution revealed the cytochrome P450 Wpa...
Zn(II)-Catalyzed Isomerization/Asymmetric [3+2] Cycloaddition of 3-Butynoyl Pyrazole with Nitrones: Subsequent Exocyclic Olefin Isomerization and Capture [0.03%]
锌(II)催化3-丁酰基吡唑与硝酮的异构化/不对称[3+2]环加成：随后的 exocyclic 亚烷基异构化和捕获
Jia-Yi Liu,Xin-Yi Chen,Ming-Sheng Xie et al.
Jia-Yi Liu et al.
A highly efficient Zn(OTf)2-catalyzed tandem isomerization/[3+2] cycloaddition cascade of 3-butynoyl pyrazole with nitrones was reported using a C1-symmetric imidazolidine-pyrroloimidazolone pyridine ligand. The resulting cycloadducts readi...
Diastereo- and Site-Selective Synthesis of Bishomoallyl Amines by Nickel-Catalyzed Multicomponent Couplings with Imines and Dienes Enabled by a Pyridyl-Phosphine Ligand [0.03%]
由吡啶磷配体促进的镍催化多组分偶联生成双氢化氨基酸的非对映和位点选择性合成
Devin T Mickles,Courtney Westlund,Justin S Marcum et al.
Devin T Mickles et al.
A catalytic multicomponent coupling method for the site-selective and diastereoselective preparation of secondary amines containing tertiary and quaternary carbon centers is disclosed. Reactions employ simple reagents (imines, 1,3-dienes, a...
AuCl3- t BuCN Catalysis in 1,2- trans 2-Deoxy-2-fluoro Glycosidic Bond Formation [0.03%]
氯金酸-tBuCN催化的1,2-反式-2-脱氧-2-氟糖苷键的形成反应
Yuanyuan Li,Zhentao Zhang,Xing Chen et al.
Yuanyuan Li et al.
Herein we report a general and efficient AuCl3-tBuCN cooperative catalysis system for the synthesis of 1,2-trans 2-deoxy-2-fluoro-glycosides. The reaction proceeds rapidly (15 min) under mild conditions, affording high stereoselectivity acr...
Gold(I)-Catalyzed Cyclization of Ene-Ynamide Carboxylates Involving 1,2-Group Migration: Synthesis of Functionalized 2-Acylquinolines [0.03%]
金催化烯基炔胺羧酸酯环化反应中涉及1,2-基迁移：功能化2-酰氧喹啉合成
Mingduo Lu,Jiaxiao Lv,Wanjun Zheng et al.
Mingduo Lu et al.
A gold-catalyzed cascade cyclization of ene-ynamides bearing a propargyl carboxylate moiety has been developed, which involves a 1,2-migration of the alkene substituent as a key step. The method provides an efficient route for the synthesis...
Organoiodine-Catalyzed Desymmetric Fluorolactonization of α,α-Diallylcarboxylic Acids to Access α-Quaternary Fluorinated Lactones [0.03%]
α,α-二 allyl 羧酸的不对称氟化 lactonization 反应以获得 α- 四元氟代内酯化合物
Jian Chen,Jiaying Li,Xiang Li
Jian Chen
The discovery of convenient and efficient methodologies for preparing optically active organofluorine compounds has received much attention from the synthetic community. Herein, we report an organoiodine-catalyzed desymmetric fluorolactoniz...
Assembly of α-Aryl Sulfones and Allyl Sulfones and Their Amide Analogues via Copper-Catalyzed Coupling Reactions [0.03%]
铜催化偶联反应构建α-芳基砜及烯丙基砜及其酰胺类化合物
Xuanhao Zhang,Lanting Xu,Bin Wu et al.
Xuanhao Zhang et al.
A method is described for the synthesis of α-aryl and allylic sulfones and sulfonamides through CuBr/oxalamide-catalyzed coupling at 40 °C. This transformation involves coupling with (hetero)aryl or vinyl bromides and 2-substituted sulfon...
Catalytic Reductive Alkylation of Pyridine-Fused N-Heteroarenes Using Alkyl Formates as Transfer Hydroalkylation Reagents [0.03%]
邻基参与的吡啶稠合N-杂环芳烃催化氢自动氧化烷基化反应
Anit Pal,Animesh Das
Anit Pal
This work reports ruthenium-catalyzed tandem reductive alkylation of N-heteroarenes to form saturated azacycles. In this reaction, alkyl formates are used as a new class of hydroalkylation reagents with LiI as a promoter. The reaction proce...