Biocatalytic Enantioselective Oxidation of N-Acyl- S-Methyl Sulfenamides for the Asymmetric Synthesis of S-Methyl Sulfoximines [0.03%]
生物催化enantioselective氧化N-酰基-S-甲基硫恩胺用于S-甲基磺酰亚胺的不对称合成
Shivani Patel,James D Finnigan,Jesmine Lim et al.
Shivani Patel et al.
Enantioenriched sulfinamides serve as key intermediates for the asymmetric synthesis of sulfoximines and other S(VI) pharmacophores. Enantioselective biocatalytic oxidation of an S-methyl sulfenamide to the corresponding S-methyl sulfinamid...
Lilan Duan,Yutao Shi,Xiaochen Ji et al.
Lilan Duan et al.
Herein, we report a direct α-C-H alkylation of alcohols with alkenes enabled by organic photoredox catalysis, in which the additive trimethylsilyl azide (TMSN3) plays a crucial role in the selective activation of the α-C-H bond of free al...
Oxidative Alkynylation of Alcohols or Aldehydes Using RuHCl(CO)(PPh3)3: Ynones Made Easy [0.03%]
钌催化醇和醛的氧化叠氮-斯瓦茨反应合成烯酮
Colin E Hayter,Sebastian Höthker,Weijia Shen et al.
Colin E Hayter et al.
Structurally diverse alcohols (or aldehydes) react with (triisopropylsilyl)acetylene to form α,β-acetylenic ketones (ynones) in good to excellent yield. This method for oxidative alkynylation exploits the commercially available air-stable...
Nickel-Catalyzed Dehydrogenation-Condensation-Rehydrogenation (DCR) Approach toward the Synthesis of Branched Primary Alcohols [0.03%]
镍催化去氢缩合加氢合成支链伯醇的DCR方法
Adrija Ghosh,Debasis Banerjee
Adrija Ghosh
We demonstrated the first Ni-catalyzed dehydrogenation-condensation-rehydrogenation (DCR) approach for the cross-coupling of two primary alkyl alcohols to β-alkylated primary alcohols. A wide variety of primary alkyl, aryl, and heteroaryl ...
Isothioureas as Coupling Partners in P-S Bond Formation through Cross-Dehydrogenative Coupling [0.03%]
硫磷键交叉脱氢偶联反应中的异硫脲类偶联试剂研究
Eimear Courtney,Gian L Reber,Nikita Liasiuk et al.
Eimear Courtney et al.
Isothioureas have been demonstrated as practical sulfur donors for mild, one-pot P-S bond formation. Treatment with piperidine releases thiolate, which undergoes aerobic oxidation to the corresponding disulfide. Subsequent cross-dehydrogena...
Photoreductive Coupling of Unactivated Ketones and Alkenes via Kinetic Suppression of Ketyl Radical Overreduction [0.03%]
动力学抑制酮基自由基过度还原下的未活化酮和烯烃的光还原偶联反应
Jiawei Bu,Hui Hao,Shiyu Chen et al.
Jiawei Bu et al.
A direct photoinduced electron transfer strategy that employs phenolate anions as photocatalysts for the efficient generation of ketyl radicals was developed. The photoexcited phenolate catalyst serves as the sole potent reductant in the re...
Silver-Catalyzed 1,3-Ditrifluoromethoxylation and 1,3-Fluorotrifluoromethoxylation of Arylcyclopropanes [0.03%]
芳基环丙烷的银催化1,3-二 trifluoromethoxy化和1,3-氟 trifluoromethoxy化反应
Fan Zhou,Lei Fang,Yafeng Si et al.
Fan Zhou et al.
Despite the existence of two synthetic methods for installing dual OCF3 groups, both are limited to 1,2-selectivity, and the strategic incorporation of bis(trifluoromethoxy) groups at 1,3-positions remains unexplored. Herein, we developed t...
l-Proline-Derived Chiral Primary Amine/Copper Dual Catalysis: Highly Chemo- and Enantioselective α-Amination Reactions of Branched β-Ketocarbonyls [0.03%]
脯氨酸衍生物手性伯胺/铜双催化体系：分支β-酮羰基α-氨化的高立体选择性反应
Jiwan Yun,Sudip Shit,Jin Won Lee et al.
Jiwan Yun et al.
Herein, we report the development of an emerging class of l-proline-derived chiral primary amine catalysts and demonstrate their high efficiency in the α-amination of a broad range of branched acyclic β-keto esters, amides and 1,3-diketon...
Gold-Catalyzed Reactions of o-Alkynylarylaldehydes with Alkenes for the Synthesis of 3,4-Dihydronaphthalene Derivatives [0.03%]
金催化o-炔基芳醛与烯烃反应合成3，4-二氢萘衍生物
Can Yang,Yan Yang,Moyi Liu et al.
Can Yang et al.
Herein, we report a selective synthesis of 3,4-dihydronaphthalene derivatives from o-quinodimethane (o-QDM) intermediates by gold(I). This method is achieved through [(BINAP)2Au2(BArF4)2]-catalyzed reactions of o-alkynylarylaldehydes with a...
High-Energy Azo-Bridged Dinitramino Materials Featuring a Planar Fused [1,2,4]Triazolo[1,5- b][1,2,4,5]tetrazine Scaffold [0.03%]
一种新型平面杂环高能偶氮桥二硝胺类化合物
Youhai Liu,Tianyu Jiang,Shiliang Huang et al.
Youhai Liu et al.
Here, a series of azo-bridged high-energy materials (compounds 4-7) based on a fused [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazine scaffold were synthesized. Fused azo-bridged dinitramino compound 5 exhibits a high heat of formation of 5.38 kJ g...