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l-Proline-Derived Chiral Primary Amine/Copper Dual Catalysis: Highly Chemo- and Enantioselective α-Amination Reactions of Branched β-Ketocarbonyls

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Herein, we report the development of an emerging class of l-proline-derived chiral primary amine catalysts and demonstrate their high efficiency in the α-amination of a broad range of branched acyclic β-keto esters, amides and 1,3-diketones using N-hydroxyca... ...