Phosphorothiolation of Benzylic C(sp3)-H via EnT-Mediated Radical-Radical Cross-Coupling [0.03%]
基于EnT介导的自由基-自由基交叉偶联的季碳sp3C-H磷硫化反应
Pengbo Zhang,Xinyi Guo,Mengke Yang et al.
Pengbo Zhang et al.
Direct phosphorothiolation of benzylic C(sp3)-H bonds remains underexplored. Herein, we report an energy transfer (EnT)-mediated method that achieves this via controlled radical-radical cross-coupling, using inexpensive K2S2O8 as both an ox...
Mono- and Bisphosphonylation of Aryl Chlorides via Phenothiazine Organophotoredox Catalysis [0.03%]
苯并噻唑有机光氧化还原催化芳基氯的单、双磷酸化反应
Yuta Goto,Haru Ando,Hiroyoshi Takamura et al.
Yuta Goto et al.
Aryl phosphonates are important structural motifs in a variety of fields, including pharmaceuticals and functional materials. While methods for the phosphonylation of aryl iodides and bromides have been widely developed, the corresponding t...
Photoredox Cobalt-Catalyzed Regio- and Stereoselective Reductive Coupling of Alkynes and Pinacol Vinylboronate with Triethylamine as Both an Electron and Hydrogen Donor [0.03%]
三乙胺同时作为供电子体和供氢体的光氧化还原钴催化烯炔与倍半碳硼烷区域选择性及立体选择性偶联反应
Chen Chen,Yan-Lin Li,Ji-Bao Xia
Chen Chen
While conventional methods for constructing homoallylic boron scaffolds face limitations in pre-functionalization requirements and selectivity control, we herein disclose a visible-light-driven photoredox cobalt-catalyzed system that enable...
Construction of Chiral 1,2-Azaborines via Rhodium-Catalyzed Enantioselective Carbene N-H Bond Insertion [0.03%]
手性铑催化剂催化亚胺烯烃环化反应合成1,2-偶氮硼烷类化合物
Jin-Ping Zhang,Wei-Ji Liu,Yuefei Hu et al.
Jin-Ping Zhang et al.
The development of general and efficient strategies for the synthesis of chiral 1,2-azaborines remains scarce and challenging. Here, we report a Rh-catalyzed enantioselective carbene N-H bond insertion to construct a series of chiral 1,2-az...
UV Light-Mediated Generation of Ketyl Radicals with a Concurrent 1,2-Boron Shift and One-Pot Synthesis of Benzoxaboroles under Continuous-Flow Conditions [0.03%]
连续流动条件下紫外光介导的偶极重排反应及其一锅法合成苯并氧杂硼撑化合物
Kankanala Naveen Kumar,Chandrakant Sahu,Pranjal Mahindrakar et al.
Kankanala Naveen Kumar et al.
The photocatalyzed reactions using metal and organic photocatalysts generate ketyl radicals by a single-electron transfer, proton-coupled electron transfer mechanism. Photocatalyst-free UV light-mediated generation of ketyl radicals in the ...
Oxone-Mediated Radical Trifunctionalization of Allyl Carboxylates via 1,2-Ester Migration [0.03%]
通过1,2-酯迁移的烯丙基羧酸酯自由基 trifunctionalization 的 Oxone 医学媒介反应
Xiao-Rong Shu,Jun-Qi Liu,Ming-Qi Yang et al.
Xiao-Rong Shu et al.
Radical-mediated trifunctionalization of alkenes, by enabling the rapid introduction of multiple functional groups, has emerged as one of the most effective strategies for the construction of functionally diverse and structurally complex mo...
Selective Reductive Elimination from Pd(IV)-Enabled Dual C-H Alkylation [0.03%]
钯(IV)介导的双C-H官能团化反应中的选择性还原消除现象
Qiongqiong Zhu,Xiang Zuo,Dongdong Tu et al.
Qiongqiong Zhu et al.
Reductive elimination is a fundamental step in organometallic transformations, yet controlling the selectivity between two (hetero)aryl groups during this process from a Pd(IV) center remains a significant challenge. Herein, we report selec...
Enantioselective Beckmann Rearrangement through Organocatalytic Desymmetrization of Cyclobutanones for the Synthesis of 4,4-Disubstituted γ-Lactams [0.03%]
通过有机催化环丁酮的非对称转化合成4，4-二取代γ-内酰胺化合物
Antón Igartua,Liher Prieto,Uxue Uria et al.
Antón Igartua et al.
The Beckmann rearrangement stands as a powerful and atom economic transformation, and its enantioselective version has not yet been found. This work presents the organocatalytic enantioselective desymmetric synthesis of γ-lactams from proc...
Alkyl and Aryl Thioester Synthesis via N-Heterocyclic Carbene-Catalyzed α-Thio Aldehyde Rearrangement [0.03%]
N-杂环卡宾催化α-硫醛基重排制备烷基和芳基硫酯反应
Tatsuya Fujiwara,Tsubasa Inokuma,Ken-Ichi Yamada
Tatsuya Fujiwara
We have developed a highly atom economic transformation to provide a thioester. The N-heterocyclic carbene-catalyzed rearrangement of α-thio aldehydes affords thioesters in good yields. This reaction exhibits a broad substrate scope and is...
Photochemical Construction of Trifluoromethyl Bicyclo[1.1.1]pentyl-heterocycles [0.03%]
光化学构建三氟甲基双环[1.1.1]戊烷杂环化合物
Marta Gil-Ordóñez,Albert Gallego-Gamo,Yingmin Ji et al.
Marta Gil-Ordóñez et al.
We describe a transition-metal-free photocatalytic synthesis of CF3-BCP-oxindoles via radical cascade annulation. This mild and sustainable protocol employs a bench-stable thianthrenium CF3-BCP reagent and activated anilides under visible-l...