Re-Catalyzed [3 + 3] Annulation for Rapid Assembly of Multisubstituted Pyridines from β-Enamino Esters and 1,3-Enynes/3-Ethynyl Indoles [0.03%]
Yidan Qi,Yuanyuan Hu,Bingwei Zhou et al.
Yidan Qi et al.
Although rhenium-catalyzed annulation reactions are well-established, [3 + 3] annulations have remained elusive. We herein demonstrated a Re-catalyzed [3 + 3] annulation of β-enamino esters with 1,3-enynes affording a wide range of multisu...
Artemverlotolides A and B, Two Sesquiterpenes from Artemisia verlotorum Lamotte: Structural Elucidation, Bioinspired Synthesis, and Antineuroinflammatory Activity [0.03%]
Mingbi Xu,Mengyu Wang,Chiyun Zhu et al.
Mingbi Xu et al.
Artemverlotolides A (1) and B (2), two unprecedented sesquiterpenes possessing a 10-oxa-tetracyclo[3.3.2.1.1.04,10.07,8]tridecane scaffold for 1 and an 11-oxa-tetracyclo[3.3.3.1.04,10.04,11.07,8]tetradecane backbone for 2, were isolated fro...
Photochemical Boronate Rearrangement Enables the One-Pot Synthesis of 2,4-Difunctionalized 2 H-Chromenes [0.03%]
Chenyang Xu,Yixin Zhang,Yiyun Chen
Chenyang Xu
2H-Chromenes are privileged pharmaceutical scaffolds, yet their synthesis typically requires multistep sequences or harsh conditions. We report a one-pot, visible-light-mediated strategy that directly converts 2'-hydroxychalcones and organo...
Blue Light-Promoted O-H Insertions of Silanols and Functionalization of Silicon Nanomaterials [0.03%]
Kevin Blanco-Herrero,Annaliese K Franz
Kevin Blanco-Herrero
We report the conversion of the silanol O-H bond through a blue light-promoted insertion strategy using diazo compounds. Various silyl ethers can be accessed in excellent yields (up to 90%) and rapid reaction times under mild conditions and...
Construction of α-Acyl-β-amino Amides via Multicomponent Reactions of β-Acyloxy Alkenyl Amides with Amines and Aldehydes [0.03%]
Wenli Tong,Huan Gao,Weijun Yao et al.
Wenli Tong et al.
Herein, we describe a novel multicomponent synthesis of α-acyl-β-amino amides with structural diversity and brevity from aldehydes, amines, and β-acyloxy alkenyl amides (AAAs). In this multicomponent protocol involving fragmentation and ...
Nan Zhou,Ruihua Liu,Cong Shi et al.
Nan Zhou et al.
Herein, we report a photoinduced fluoroalkylalkynylation of alkenes with terminal alkynes under mild conditions, without the need for coupling metal catalysts or preformed alkynyl reagents. It proceeds via a radical cascade that hinges on r...
Modular Synthesis of Tetrasubstituted Thioallenoates via the Tandem Wolff Rearrangement/C-S Bond Insertion Reaction of Alkynyl Diazoketones and N,S-Acetals [0.03%]
Xuedi Zhao,Yuhao Ni,Zhihua Cai et al.
Xuedi Zhao et al.
Here, we present an approach for one-pot synthesis of tetrasubstituted thioallenoates via the addition of N,S-acetals to alkynyl ketenes generated in situ from alkynyl diazoalkyl ketones under photoirradiation. This reaction proceeds throug...
Difluoro(methoxy)methyl Is a Neglected Group for Medicinal Chemistry─Revival via CF2OMe-Containing Amines [0.03%]
Mykhailo O Pashko,Dmitry S Granat,Oleksii O Klymenko-Ulianov et al.
Mykhailo O Pashko et al.
An efficient, scalable approach to CF2OMe-containing amines is reported. The scope and limitations of the reaction are delineated, including the influence of structural features and the nature of the protection group. The resulting CF2OMe a...
SmI2/Sm-Mediated Desulfurative Fluoroarylation of Thioamides with Polyfluoroarenes via C═S/C─H Bond Cleavage [0.03%]
Yongqi Liang,Zhiming Qiao,Yu Gao et al.
Yongqi Liang et al.
A robust samarium diiodide/samarium-mediated desulfurative fluoroarylation of thioamides with polyfluoroarenes via C═S/C─H bond cleavage is reported. This method represents the first example of desulfurative fluoroarylation of thioamides ...
Enantioselective Pd-Catalyzed Electrochemical Dearomative Allylation of Tropones: Construction of All-C Quaternary Stereocenters [0.03%]
Giulia Monda,Sofia Kiriakidi,Olalla Nieto Faza et al.
Giulia Monda et al.
A Pd-catalyzed electroreductive enantioselective dearomatization of tropones is documented. High levels of chemoselectivity toward the formation of seven-membered ring ketones featuring a stereochemically controlled all-carbon α-stereocent...