Synthesis of 1,3-Bis-trifluoromethylated (Hetero)cyclohexane-2-carboxylates from Alkylidenemalononitriles [0.03%]
由烯基甲基酮腈合成1,3-双三氟甲基化环己烷-2-羧酸酯类化合物
Morgane Mando,Akash R Gogate,Dylan J Smith et al.
Morgane Mando et al.
Reported herein is a method for the syn-selective 1,3-bis-trifluoromethylation of (hetero)cycloalkylidenemalononitriles. The malononitrile-containing intermediate can be readily converted into carboxylates (and derivatives thereof) by oxida...
Solution-Phase and Mechanochemical Brønsted-Acid-Catalyzed N-Alkylation of NH-Heterocycles via Hydroamination of Vinyl Ethers [0.03%]
通过乙烯基醚的氢胺化有效进行杂环化合物N-烷基化的溶液和机械化学方法
Vikash Kumar,Rajaram Maayuri,L N S Laya Pagadala et al.
Vikash Kumar et al.
A Brønsted-acid-catalyzed hydroamination of vinyl ethers with carbazoles was developed using diphenyl hydrogen phosphate (DPHP) as the catalyst. The method enables the efficient, regioselective N-alkylation of various carbazoles and NH-het...
Nickel-Catalyzed Enantioselective Reductive Alkenylation of N-Pyridyl Aldimines via a Mechanism of Elementary 1,4-Addition [0.03%]
镍催化N-吡啶亚胺的对映选择性还原烯基化反应的新机理研究
Mengxin Zhao,Bo Xiao,Lantian Sun et al.
Mengxin Zhao et al.
Chiral nickel complexes of isoquinox catalyze an asymmetric reductive alkenylation of N-picolyl aldimines with readily available alkenyl bromides, triflates, and tosylates as carbon electrophiles. The method features neutral and mild condit...
Catalytic Asymmetric Synthesis of 1,2-Fused Tricyclic Indoles Containing an Eight-Membered Biaryl Bridge [0.03%]
含八个成员.bi环桥的1,2-并三环吲哚的催化性不对称合成
Hao Feng,Heyu Hu,Junling Zhao
Hao Feng
We disclose herein a diastereo- and enantioselective synthesis of tricyclic indoles containing an eight-membered-ring-bridged biaryl architecture from 2-(2-aminoaryl)indoles and β,γ-unsaturated α-ketoesters. This Friedel-Crafts alkylatio...
Palladium-Catalyzed Enantioselective Dearomatization of Furan To Access N, O-Spirocycles [0.03%]
钯催化呋喃的高度对映选择性去芳构化以合成N,O-螺环化合物
Xinyue Wang,Chun Ma,Junfeng Yang et al.
Xinyue Wang et al.
N,O-Spirocycles are important structural motifs in efficient chiral ligands, natural products, and pharmaceuticals. However, the achievement of highly enantioselective N,O-spirocycles remains a challenge. Herein, we present a Pd-catalyzed e...
Reverse Regioselectivity of Aminopalladation: Palladium-Catalyzed Oxidative Tandem Cyclization for the Construction of Aza-oxabicyclo[4.2.1]nonane [0.03%]
反向区域选择性氨基钯化反应：钯催化氧化串联环化反应构建aza-oxabicyclo[4.2.1]nonane骨架
Yiteng Cai,Xiangwen Tan,Wanqing Wu et al.
Yiteng Cai et al.
Palladium-catalyzed oxidative tandem cyclization enabled by nucleopalladation has been demonstrated to be an effective strategy for the construction of polycyclic structures. However, due to the tendency to form a thermodynamically favorabl...
Lucas G Furniel,Kauê C Capellaro,Viktor S Câmara et al.
Lucas G Furniel et al.
The first examples of enantioselective α,α-chlorofluorination of α-carbonylsulfoxonium ylides are described. Herein, two modes of reaction are explored, using chiral aminosulfoxonium ylides and a chiral fluorinating reagent, prepared in ...
Asymmetric Synthesis of cis-3α-Aryloctahydroindole Alkaloids by Ene-Reductase Dehydrocyclization [0.03%]
烯还原酶去氢环化介导的cis-3α-芳基八氢吲哚生物碱的不对称合成
Jianjiong Li,Siyu Li,Yu Wang et al.
Jianjiong Li et al.
In this study, an unprecedented, enzymatic, and enantioselective desymmetrization and cyclization reaction of achiral 4,4-disubstituted cyclohexanones has been developed for the asymmetric synthesis of cis-3α-aryloctahydroindole alkaloids ...
Ni-Catalyzed (A + 2B)-Type Reductive Coupling of Electron-Deficient Alkenes and Alkynes through a Selective Trimerization/1,6-Reduction Cascade [0.03%]
镍催化电子缺电子烯烃和炔烃的(A+2B)型还原偶联：通过选择性三聚化/1,6-还原级联反应实现
Ming-Bai Gou,Deng-Yin Gou,Chun-Min Yang et al.
Ming-Bai Gou et al.
The first nickel-catalyzed (A + 2B)-type reductive coupling of electron-deficient alkenes with alkynes has been developed. This method provides efficient access to diverse α-skipped dienyl esters in up to 99% yield with high chemo- and ste...
Chemodivergent Synthesis of 1,4-Benzo[ b]dithiins and 1,4-Benzodithiafulvenes [0.03%]
苯并二噻吩和苯并二噻杂富烯的化学分歧合成法
Douglas B Paixão,Anita B Kessler,Fabiano S Rodembusch et al.
Douglas B Paixão et al.
We report a chemodivergent synthesis of 1,4-benzo[b]dithiins and 1,4-benzodithiafulvenes from 2-iodoaryl alkynyl sulfides using a NaSH·xH2O/KOH system. In DMF, the reaction affords six-membered 1,4-dithiins, whereas in DMSO, these intermed...