Divergent Reactivity of Diketopyrrolopyrroles: Ring-Opening with Amines [0.03%]
二酮吡咯并吡咯的不同反应活性：与胺的开环反应
Vitor A S Almodovar,Gonçalo F Oliveira,Nuno R Candeias et al.
Vitor A S Almodovar et al.
We report an unprecedented reaction of a diketopyrrolopyrrole (DPP) with primary and secondary amines that results in the ring-opening of the core with loss of its fluorescence. The various characterization techniques used in this study, su...
Discovery of Diverse Esterified seco-Polycyclic Polyprenylated Acylphloroglucinols from Two Species of Hypericum Linn. and Their Lipid-Lowering Effect [0.03%]
两种Hypericum(L.)属植物酯化半萜双苯环菲醌丙烯酸没药树脂酚类成分的多样性研究及其降脂活性
Zhaoyue Dong,Yulu Xie,Kun Wu et al.
Zhaoyue Dong et al.
Hyperesternoids A-K (1-11, respectively), 11 unique esterified seco-PPAPs (seco-polycyclic polyprenylated acylphloroglucinols) with three types of scaffold systems, 5/6 bicyclic (1-3), 5/7/6 tricyclic (4-6), and 5/6/6 tricyclic (7-11), were...
Mechanochemistry-Enhanced Regioselective Hydrophosphinylation of Acrylamides and Enamides [0.03%]
机械化学增强的丙烯酰胺和烯酰胺区域选择性水合磷化反应
Zi-Kui Liu,Yun-Kun Su,Cong-Fang Cheng et al.
Zi-Kui Liu et al.
Herein, we report a ball milling technique for the regioselective hydrophosphinylation of acrylamides and enamides, utilizing readily available Ph2PCl as the phosphine source and H2O as an additive under metal-free and toxic solvent-free co...
A Three-Layer Transformation Strategy toward Functionalized Fused Hydantoins and Diketopiperazines [0.03%]
功能化融合氢胸氨酸和二酮哌嗪的三层转换策略
Maria-Aikaterini Giannakaki,Marios Zingiridis,Konstantinos G Froudas et al.
Maria-Aikaterini Giannakaki et al.
We present mAUCy (modified Asinger-Ugi cyclization), a scalable three-layer strategy enabling rapid synthesis of diverse thiazolo hydantoins and diketopiperazines. Beginning from 3-thiazolines via a modified Asinger reaction, followed by an...
Chiral Carboxylic Acid Assisted Ir(III)-Catalyzed Asymmetric C-H Activation/Desymmetrization of Sulfoximines [0.03%]
手性羧酸辅助的铱催化不对称C-H活化/硫oximation的非对映选择性生成
Rihuang Pan,Hanxiao Shen,Yinong Wu et al.
Rihuang Pan et al.
The development of privileged chiral carboxylic acids is crucial for enabling asymmetric C-H activation catalyzed by achiral high-valent d6 transition metals. We report the synthesis of a new chiral carboxylic acid that enables Ir(III)-cata...
Tetrazole Synthesis via Cyclopropenium Phase-Transfer Catalysis: A Click Strategy [0.03%]
通过 cyclopropenium 相转移催化合成四氮唑：一种点击策略
Srini Vemulapalli,Travis Dudding
Srini Vemulapalli
Morden organic synthesis prizes efficiency, robustness, and generality─hallmarks of click chemistry. Here, we introduce a metal-free catalytic method for synthesizing diverse tetrazole heterocycles from simple, shelf-stable precursors. Cen...
Selective Synthesis of anti-Bisbenzo[ b]thieno[2,3- b:2',3'- e][1,4]dithiin via Copper-Catalyzed Domino Formation of Eight C-S Bonds [0.03%]
通过铜催化连续形成八个C-S键的级联反应高选择性合成反式双苯并[b]噻吩并[2,3-b:2',3'-e][1,4]二硫素
Wenyu Lai,Xinrui Cui,Kexin Xu et al.
Wenyu Lai et al.
A copper-catalyzed C-S bond-forming reaction of o-halophenylacetylenes selectively affords anti-bisbenzo[b]thieno[2,3-b:2',3'-e][1,4]dithiins (anti-BBTDs). This approach features a domino thienannulation reaction, a mild temperature, an ine...
Palladium-Catalyzed Regiodivergent [4 + 2] Cycloaddition of Benzosilacyclobutenes with Phenylpropiolonitriles [0.03%]
钯催化苯基丙二腈与苯硅环丁烯区域选择性[4+2]环加成反应
Xing-Ben Wang,Jun-Jie Guo,Ming-Hao Shen et al.
Xing-Ben Wang et al.
The controlled diversification of reaction pathways from a common substrate through precise modulation of catalyst systems represents a persistent challenge in catalysis and synthetic chemistry. Herein, we report a ligand-controlled Pd-cata...
Photocatalytic Copper-Promoted Heptafluoroisopropylation of Arylsulfonium Salts with AgCF(CF3)2 [0.03%]
光催化铜促进的芳基硫酸盐与AgCF(CF3)2的七氟异丙基化反应
Jiang-Yu Li,Cheng-Pan Zhang
Jiang-Yu Li
A copper-promoted synthesis of heptafluoroisopropylarenes through visible-light-induced coupling of arylsulfonium salts with AgCF(CF3)2 is presented. The reaction, conducted at room temperature under 420 nm LED irradiation, efficiently conv...
Uranyl-Enabled Photocatalytic C(sp3)-H Functionalization with Azoles [0.03%]
联芳基卡宾催化剂用于α-氨基酮的分子内偶联反应
Yin-Ying Luo,Shu-Yun Zhang,Yan-Xin Jiang et al.
Yin-Ying Luo et al.
Under mild conditions, uranyl nitrate catalyzed C(sp3)-center/azole coupling without external additives, offering a broad substrate scope and high yields (up to 95%). The method was further validated under sunlight and in scale-up experimen...