Organophotoredox-Catalyzed Alkylation of Vinylsulfur Pentafluoride: Expanding Access to SF5-Containing Aliphatic Molecules [0.03%]
有机光氧化还原催化乙烯基硫五氟化合物的烷基化反应：扩大合成含SF5脂肪族分子的范围
Laurianne Verret,Pascal Paquin,Martin Le Roy et al.
Laurianne Verret et al.
The pentafluorosulfanyl (SF5) group is a valuable fluorinated motif, but aliphatic SF5 synthesis remains challenging. We report a metal-free organophotoredox strategy to access aliphatic SF5 compounds via alkylation of vinylsulfur pentafluo...
Strain-Release Asymmetric Multicomponent Reaction to Access Diverse N-α-Bisaryl-C3-quaternary Azetidines [0.03%]
释放张力的不对称多组分反应构建多样性N-α-双芳基-C3季碳氮杂环丁烷类化合物
Suparna Mondal,Debu Ghorai,Saleha Khatun et al.
Suparna Mondal et al.
Azetidines are valuable motifs in drug discovery, yet access to densely substituted N-α-bisaryl-C3-quaternary azetidines remains limited. We report a strain-release multicomponent Petasis borono-Mannich reaction that enables the modular sy...
DDQ-Mediated Oxidative [5+2] Cycloaddition Reactions of Isochroman-4-ones with Alkynes [0.03%]
DDQ介导的异色满-4-酮与炔烃的氧化[5+2]环加成反应
Long Liang,Sen Yang,Xiao-Guo Zhang et al.
Long Liang et al.
A DDQ (2,3-dichloro-5,6-dicyano-1,4-benzoquinone)-mediated oxidative [5+2] cycloaddition of isochroman-4-ones with alkynes has been described. This strategy provides an alternative method for the generation of the key benzopyrylium ylides a...
Xiaoyu Fang,Yu Jiang,Yuhan Xiao et al.
Xiaoyu Fang et al.
The first total synthesis of chrysosporazines B and C was accomplished in a concise and highly stereoselective manner with overall yields of 9.2% and 8.0%, respectively. Highlights of the synthesis include a Suzuki-Miyaura coupling of E-eno...
Divergent Total Synthesis of Tacaman Alkaloids: A Skeleton Reorganization Strategy [0.03%]
塔卡曼生物碱发散式全合成：骨架重构策略
Xiao-Feng Guo,Ya-Kui Sun,Jin-Bao Qiao et al.
Xiao-Feng Guo et al.
Herein, we present a divergent synthesis of tacaman alkaloids featuring a pivotal pentacyclic intermediate bearing an exocyclic trisubstituted olefin, accessed via a base-promoted intramolecular cyclopropanation/cyclopropane ring-opening/ox...
Highly Regioselective Hydroaminomethylation for Amine Synthesis Enabled by a Heterogeneous Molecular Catalyst Ru3/QDPOP [0.03%]
Ru3/QDPOP杂化分子催化剂用于高度区域选择性氢胺甲基化反应合成伯胺研究
Zhaozhan Wang,Yinghao Zhu,Bhalchandra M Bhanage et al.
Zhaozhan Wang et al.
In this work, we report an efficient protocol for direct amine synthesis from alkenes catalyzed by a heterogeneous molecular catalyst Ru3/QDPOP, which features well-defined trinuclear Rh centers stabilized by a phosphine-functionalized poro...
Direct Synthesis of Fluorinated Polycyclic Aromatic Dioxanes: Mesomorphism, Luminescence, and Charge Transport [0.03%]
含氟多环芳烃二氧烷的直接合成及其柱状液晶、发光和载流子传输性质研究
Meng-Xiang Hao,Zi-Ling Ou,Hai-Feng Wang et al.
Meng-Xiang Hao et al.
We report a straightforward synthesis of new Janus-fluorinated dioxa-bridged tetracene and pentacene liquid crystals. These materials self-assemble into stable columnar mesophases driven by noncovalent perfluoroarene-arene interactions that...
Nickel-Catalyzed Regioselective Hydroalkynylation of Nitrogen Heterocycle-Tethered Unactivated Alkenes [0.03%]
镍催化氮杂环连接的非活化烯烃区域选择性氢炔基化反应
Jin-Tao Wang,Yi-Hui Li,Hua-Feng Cao et al.
Jin-Tao Wang et al.
The hydroalkynylation of unactivated olefins presents a significant challenge, primarily due to difficulties in controlling the regioselectivity and competing reaction pathways. Herein, we report a practical NiH-catalyzed γ-selective hydro...
Synergistic Photoenzymatic Catalysis Enables Enantioselective Synthesis of γ-Amides via a Ternary Electron Donor-Acceptor Complex [0.03%]
三元电子给体-受体复合物介导的协同光酶催化实现γ-酰胺的不对称合成
Yao Yao,Ming-Liang Shi,Xin-Yue Fan et al.
Yao Yao et al.
The development of photoenzymatic non-natural reactions facilitates the synthesis of challenging high-value-added chiral compounds. However, this approach typically requires enzyme engineering to enhance both the catalytic activity and sele...
Polycyclic Limonoids as Potential Nrf2 Inducers from Trichilia connaroides [0.03%]
来源于刺果白树的多环柠檬苦素类Nrf2诱导活性成分研究
Jia-Xin Xu,Yan Zhang,Long Wang et al.
Jia-Xin Xu et al.
An investigation of Trichilia connaroides uncovered connarolides A-D (1-4, respectively), four limonoids with exceptional multiring systems. Compound 1 showcased a unique 5/8/6/6-fused ring system distinguished by a bicyclo[5.2.12,4]decane ...