Dual Photoredox/CpTi(IV)-Catalyzed Reductive Cyclization of Tertiary Bromide with Nitrile for Constructing 4a,9a-Heterocycle-Fused Tetrahydrocarbazole [0.03%]
通过三溴化物与腈的还原环化构建4a,9a-杂环并四氢 карбазоле_dual光氧化还原/CpTi(IV)催化体系下的三级溴化物与腈的还原 cyclization反应
Yanxia Zhen,Zhijiang Ma,Guanghui Fan et al.
Yanxia Zhen et al.
In this study, dual photoredox/CpTi(IV) catalysis has been developed for the reductive cyclization of 3a-bromo-hexahydropyrroloindoline or 3-bromo-tetrahydrofuroindole with the appendage nitrile, providing rapid access to a series of 4a,9a-...
Regio- and Stereoselective Synthesis of Polysubstituted γ-Lactams Enabled by Photocatalyzed Sequential Radical Aminoalkylation of MBH Acetates [0.03%]
MBH酯的光催化连续自由基氨烷基化 enable 的区域和立体选择性合成多取代γ-内酰胺
Jie Huang,Yan-Hong He,Zhi Guan
Jie Huang
A visible-light photocatalytic method is reported for the regio- and stereoselective synthesis of polysubstituted γ-lactams from N-arylglycines and Morita-Baylis-Hillman (MBH) acetates. The reaction proceeds through sequential radical amin...
Direct Photoexcitation Enables Nickel-Catalyzed C(sp3)-C(sp3) Coupling of α-Bromonitriles with Alkylzirconocenes [0.03%]
镍催化α-溴腈与烷基锆化合物直接光激发下(sp3)-(sp3)偶联反应
Jianru Xie,Jianguo Han,Xiushan Liu et al.
Jianru Xie et al.
We report a visible-light-mediated nickel-catalyzed C(sp3)-C(sp3) cross-coupling between α-bromonitriles and alkylzirconocene reagents enabled by a direct photoexcitation strategy. Alkyl radicals are generated from in situ formed alkylzirc...
Cu(I)-Catalyzed Radical Coupling of Alkenes with Sulfonimidoyl Chlorides: Synthesis of Vinyl Sulfoximines [0.03%]
铜催化下烯烃与磺亚胺氯的自由基偶联反应： vinyl sulfoximine 的合成
Yang Yang,Ru Liu,Huan Yang et al.
Yang Yang et al.
A Cu(I)-catalyzed radical coupling was reported for the synthesis of vinyl sulfoximines from sulfonimidoyl chlorides and alkenes under mild, light-free conditions. This method proceeds via a sulfonimidoyl radical intermediate, generated thr...
[4 + 2] Annulation of CF3-π-Allyl-Pd Species with Isatic Acids for Direct Access to 3-Trifluoroethyl-4-carboxylate Quinolines [0.03%]
[4+2]异酸酐与CF3-π-丙烯基-钯物种反应直接合成3-三氟乙基-4-羧酸酯喹啉类化合物
Rami Sateesh,Chiliveru Priyanka,Krishna Swaroop Desireddy et al.
Rami Sateesh et al.
Herein, we report a catalytic [4 + 2] annulation between trifluoromethyl allyl carbonates and isatic acids that provides direct access to 3-trifluoroethyl-4-carboxylate quinolines. The transformation proceeds smoothly under mild conditions ...
Tandem Nitration-Cyclization-Rearrangement of Indole-Tethered 1,6-Enynes To Access NO2-Featured Heterocycles [0.03%]
通过串联硝化-环化-重排反应构建含氮杂环化合物
Zexuan Liu,Qinqin Yan,Huaqing Liu et al.
Zexuan Liu et al.
An efficient cascade nitration-annulation-rearrangement of indole-tethered 1,6-enynes, tert-butyl nitrite (TBN) with O2 was developed for the synthesis of various NO2-dicarbonyl substituted pyrrolo[1,2-a]indole derivatives. This radical cas...
Synthesis of Enantioenriched Difluoromethylated Allenes via Copper-Catalyzed Stereospecific Difluoromethylation [0.03%]
铜催化立体选择性二氟甲基化反应合成富集对映体的二氟甲基联芳基化合物
Su Chen,Jeanette A Krause,Yushu Zhang et al.
Su Chen et al.
Axially chiral allenes are valuable motifs in natural products and chiral ligands in asymmetric catalysis, yet methods to access enantioenriched difluoromethylated analogues remain undeveloped. Here we report the efficient copper-catalyzed ...
Enantioselective Total Synthesis of (+)-Subincanadine F via Organo-SOMO Catalysis [0.03%]
手性亚胺催化的有机SOMO催化(+)-subincanadine F的全合成
Tian-Yuan Zhang,Chun-Yan Peng,Bin Liu et al.
Tian-Yuan Zhang et al.
The asymmetric total synthesis of (+)-subincanadine F has been achieved in only 9 steps from commercial tryptamine. A key step involves an Organo-SOMO-catalyzed α-arylation of aldehydes to construct the azepino[4,5-b]indole core. Finally, ...
Homogeneous Reductant Facilitated Cross-Electrophile Coupling of Aryl Bromides with NHP Esters [0.03%]
溴芳烃与内酰胺酯的等摩尔有导向基团催化的交叉偶联反应研究
Abhishek Kundu,Seoyeon Kim,Nilay Hazari et al.
Abhishek Kundu et al.
Alkyl-substituted N-hydroxyphthalimide (NHP) esters are valuable alternatives to alkyl halides in Ni-catalyzed cross-electrophile coupling reactions because they are typically more stable, can generate alkyl radicals under reductive conditi...
Asymmetric Synthesis of 2,2-Disubstituted Dihydroquinolines via Rhodium-Catalyzed Dearomative Arylation and Alkenylation of 2-Substituted Quinolinium Salts [0.03%]
通过铑催化喹啉
Wen-Jun Huang,Jian Chen,Yu-Qing Bai et al.
Wen-Jun Huang et al.
A synthetic protocol for the construction of chiral 2,2-disubstituted dihydroquinolines via rhodium-catalyzed asymmetric dearomative arylation and alkenylation of 2-substituted quinolinium salts has been disclosed. 2-Substituted quinolinium...