Photoinduced 1,2-Chlorothiolation of Unactivated Alkenes via Proton Transfer and Electron Transfer [0.03%]
通过质子转移和电子转移光诱导未活化烯烃的1,2-氯硫化物化反应
Chao Xie,Zemin Wang,Wenli Zhuang et al.
Chao Xie et al.
Chlorosulfur compounds, serving as structural cores in numerous bioactive molecules, represent valuable yet synthetically challenging building blocks. Herein, we report a photoinduced 1,2-chlorothiolation of unactivated alkenes enabled by p...
A General Iron-Photocatalyzed Decarboxylative Arylalkylation of Carboxylic Acids with Activated Alkenes [0.03%]
一种羧酸与富电子烯烃的铁光催化脱羧芳基烷基化反应
Yi Li,Shi-Gang Yan,Shuang Wu et al.
Yi Li et al.
We present a ligand-to-metal charge transfer (LMCT)-enabled, iron-photocatalyzed decarboxylative arylalkylation protocol for coupling readily accessible N-arylacrylamides with commercially available, structurally diverse carboxylic acids, f...
Construction of Heterocyclic-Triazolopyrimidine Framework for Energetic Compounds: High-Energy, Low-Sensitivity Explosives [0.03%]
用于性能推进材料的杂环三氮唑并嘧啶框架构建：高能低感炸药
Lei Zhao,Chungui Xue,Caijin Lei et al.
Lei Zhao et al.
This study reports the synthesis of three novel heterocycle triazolopyrimidine compounds with vicinal amino-nitro groups by introducing dinitropyrazole, nitrooxadiazole, and trinitromethyl groups into the fused-ring framework, respectively....
Jiong Xu Ng,Gang Liao,Yu Zhao
Jiong Xu Ng
Chiral sulfoxides are highly important structural motifs that find wide application in asymmetric synthesis and the pharmaceutical industry. While traditional access to chiral sulfoxides mainly relies on asymmetric oxidation of the sulfide ...
Cu-Catalyzed Atroposelective Protoboration of Allenes to Access Stereodefined Tetrasubstituted Axially Chiral Alkenylboronates [0.03%]
铜催化亚磷酸酯参与的亚胺烯烃的动力学分辨率反应及手性四取代轴手性乙烯基硼酸酯的构建
Baoli Li,Zhan Huang,Shichao Hong et al.
Baoli Li et al.
Alkenylboronates represent a cornerstone functional group in modern organic synthesis owing to their versatile reactivity in Suzuki-Miyaura cross-coupling reactions and other key transformations. However, catalytic asymmetric methods for pr...
Dithiane-Alkyne Metathesis Enables Trp(C2)-Alkene-Cross-Linked Cyclic Peptides [0.03%]
二硫烷基-炔烃交换反应实现Trp(C2)-烯烃交联环肽
Liang Li,Xiaomeng Gong,Guohong Tang et al.
Liang Li et al.
Cyclic peptides represent a privileged class of scaffolds in drug discovery owing to their unique balance between structural rigidity and functional diversity. Herein, we disclose an indium(III)-catalyzed intramolecular dithiane-alkyne meta...
Merging Photoredox with Nitro Reduction for the Direct Synthesis of Unsymmetrical Ureas [0.03%]
光氧化还原与硝基还原结合直接合成不对称脲类化合物
Shuhui Sun,Xiaowen Qin,Heng Li et al.
Shuhui Sun et al.
Unsymmetrical ureas represent a challenging structural motif of high pharmaceutical relevance, yet direct and convergent syntheses remain limited. Herein, we present a unified photoredox strategy that constructs the unsymmetric urea linkage...
Selective Synthesis of Isochromene Fused Indenone or Indane Fused Indanone Derivatives Featuring with Solvent-Dependent Intra- or Intermolecular O-H Bond Carbene Insertion [0.03%]
溶剂依赖的O-H键碳
Chang Gao,Nana Shen,Qianting Zhou et al.
Chang Gao et al.
Presented herein is a condition-controlled selective synthesis of isochromene fused indenone (3) or Indane fused indanone derivatives (4) via the cascade reactions of 3-phenyl[1,2,3]triazolo[1,5-a]pyridine (1) with diazo indanedione (2). Th...
Palladium-Catalyzed Enantioselective [3 + 2] Cycloaddition of Vinylarylcyclopropanes (VACPs) with Photogenerated Ketenes to Tetrahydrofurans [0.03%]
钯催化乙烯基芳基环丙烷与光生酮烯缩合生成四氢呋喃的不对称[3+2]环加成反应
Zhijie Ling,Jianlu Wang,Yang-Zi Liu et al.
Zhijie Ling et al.
A palladium-catalyzed asymmetric [3 + 2] cycloaddition of vinylarylcyclopropanes (VACPs) with photogenerated ketenes is disclosed. This method efficiently constructs tetrahydrofurans featuring a quaternary stereocenter with high yields and ...
Bi-Catalyzed [3 + 2] Cycloaddition of C2-Spirocyclopropyl-indolin-3-ones with Carbonyls: Access to Spiro[furan-3,2'-indolin]-3'-ones [0.03%]
C2-螺环环丙基吲哚并内酰亚胺的双催化[3+2]环加成反应：构建螺[呋喃-3，2’-吲哚啉-3’-酮]类化合物
Ming-Liang Rao,Mao Zhang,Jia-Hao He et al.
Ming-Liang Rao et al.
Herein, the first Bi-catalyzed [3 + 2] cycloaddition of C2-spirocyclopropyl-indolin-3-ones and carbonyl compounds has been developed under mild conditions, enabling efficient and diastereoselective access to multisubstituted spiro[furan-3,2...