Photoinduced Chemoselective Alkane Sulfinylation via Fe/Ni Dual Catalysis [0.03%]
铁/镍双催化光促进的选择性烷烃磺化反应
Lifang Wang,Shuyang Liu,Ran Xu et al.
Lifang Wang et al.
Sulfoxides occupy a central role in natural products and bioactive molecules, yet their direct construction from simple feedstocks remains challenging. Herein, we report a dual iron/nickel photocatalytic strategy for the selective C(sp3)-H ...
C-H Arylation of Imidazo[1,2- a]pyridines and Zolimidines Catalyzed by Synergistic Tripalladium Clusters [0.03%]
协同三钯簇催化咪唑并吡啶和唑咪啶的C-H芳基化反应
Yingrui Song,Fen Wu,Giovanni Maestri et al.
Yingrui Song et al.
Tripalladium cluster [Pd3]+-1-3 (0.33 mol %) presented superior reactivity in the C-H arylation of imidazo[1,2-a]pyridines and zolimidines with aryl halides compared to palladium monomers and nanoparticles, affording important imidazole[1,2...
Photoredox-Enabled Radical Ring-Opening Fluorosulfonamidation/Fluorosulfonylmethylation of Methylenecyclobutanols [0.03%]
光氧化还原介导的甲基环丁酮醇类化合物自由基开环氟磺酰胺化/氟磺酰甲基化反应
Hua Li,Lin Qi,Xiao-Xing Li et al.
Hua Li et al.
We report a photoredox strategy for radical-initiated ring-opening fluorosulfonamidation/fluorosulfonylmethylation of methylenecyclobutanols using NFSAP (N-fluorosulfamoylpyridinium salts) and BMSF (bromomethylsulfonyl fluoride) as the resp...
Jeremy T Maddigan-Wyatt,Daniil A Knyazev,Daniel B Werz
Jeremy T Maddigan-Wyatt
Herein, we describe a novel, light, and catalyst-free electrochemical method for the activation of bicyclo[1.1.0]butanes (BCBs) enabling cycloaddition with aldehydes and arylation with arenes. This exceptionally mild strategy for BCB functi...
Synthesis of Stilbene Derivatives via Phosphine-Catalyzed Cascade [2+4] Annulation/Decarboxylative Aromatization of Yne-Enones with α-Pyrones [0.03%]
通过膦催化串联[2+4]环化/去羧基芳构化反应合成茋衍生物：炔内酮与α-吡酮的反应
Mingxia Huang,Yi Tang,Jingrong Jin et al.
Mingxia Huang et al.
Despite significant advances in phosphine catalysis for synthesizing diverse cyclic frameworks, phosphine-catalyzed benzannulation reactions remain largely underexplored. In this work, we report a phosphine-catalyzed cascade [2+4] annulatio...
Copper-Catalyzed Intramolecular Carbocyclization/1,2-Migration Reaction of Allenols To Access Substituted 2-Sulfonyl Carbazoles [0.03%]
铜催化allenol的分子内碳环化/1，2迁移反应合成取代的2-磺酰基咔唑化合物
Puja Singh,Pooja Nain,Manoj V Mane et al.
Puja Singh et al.
A copper-catalyzed intramolecular cascade carbocyclization/1,2-migration of C-2 indolyl-allenol has been achieved to construct the library of 2-sulfonyl carbazoles, which possess considerable biological significance. This modular protocol i...
Construction of PROTAC Library via Liquid-Phase Synthesis Enabled by a Hydrophobic Tag [0.03%]
基于疏水标签的液相合成构建PROTAC文库
Yifeng Zhou,Wei He,Zehui Zhou et al.
Yifeng Zhou et al.
Herein, we present a new synthetic strategy for PROTAC development by using hydrophobic tag-assisted liquid-phase synthesis (LPS). The hydrophobic tag enables intermediates to be purified by precipitation, thus sparing the effort of column ...
Synthesis of Tetralin and Chromane Motifs via Pd-Catalyzed Dual C(sp3)-H/C(sp2)-H Bond Activation [0.03%]
钯催化双C(sp3)−H/C(sp2)−H键活化合成四氢萘和色满骨架
Sarjine Shreya Bajirao,Masilamani Jeganmohan
Sarjine Shreya Bajirao
A palladium-catalyzed intramolecular selective dual C-H bond activation between aliphatic β-C(sp3)-H and aromatic C(sp2)-H bonds of substituted sulfonamides is described. This methodology is highly compatible for building up privileged chr...
Decarboxylative and Deoxygenative/Decarbonylative Alkylation of Heterocycles with α-Keto Acids [0.03%]
α-酮酸与杂环的去羧基化和脱氧/去羰基化烷基化反应
Zelin Zhao,Qian Jing,Haiqin Liu et al.
Zelin Zhao et al.
The visible-light-assisted, self-promoted decarboxylative and deoxygenative alkylation of heterocycles from aromatic α-keto acids has been achieved without an added transition-metal catalyst, photocatalyst, or reductant under 400 nm LED ir...
Yb(OTf)3-Catalyzed [2π + 2σ] Cycloaddition of Bicyclo[1.1.0]butanes with Methylenimines for Modular Synthesis of 1,2,4-Trisubstituted 2-Aza-bicyclo[2.1.1]hexanes [0.03%]
催化合成1,2,4-三取代的2-氮杂双环[2.1.1]己烷分子模块的[2π + 2σ]环加成反应研究
Yi Cao,Huanping Xie,Xiaowen Yu et al.
Yi Cao et al.
Aromatic rings in drug candidates often exhibit poor developability. Three-dimensional bioisosteres like aza-bicyclo[2.1.1]hexanes (aza-BCHs) improve properties but face limited synthetic access to diverse substitutions. Herein, we report a...