Studies toward Pestalachloride B: Synthesis of the 6/7/6 Tricyclic Scaffold [0.03%]
帕斯他氯化物B的研究：6/7/6三环骨架的合成
Benjamin E Deprez,Andrew R LeBlanc,Qimin Winnie Yang et al.
Benjamin E Deprez et al.
Antibiotic therapy is a critical part of modern healthcare, and the discovery of antibiotics with novel mechanisms of action is needed to combat the rise of antimicrobial resistance. Pestalachloride B, isolated from Pestalotiopsis adusta, i...
Visible-Light-Induced Carbamoylation for Synthesis of Dibenzo[ b,f][1,4]oxazepine Carbonyl Amino Acid/Peptide Derivatives [0.03%]
可见光促进的 carbamoylation 反应及其在合成二苯并氧氮杂环庚烯衍生物中的应用
Fan-Lin Zeng,Jia-Nan Chen,Yu-Xin Luo et al.
Fan-Lin Zeng et al.
Introducing amino acids/peptides onto the heterocycle via photocatalytic methods remains a significant challenge. A novel visible-light-driven carbamoylation approach was first developed, facilitating the efficient synthesis of dibenzo[b,f]...
Enantioselective Synthesis of Chiral 2,2-Difluoro-spiro[indene- [1,3,4]oxadiazines] by NHC-Catalyzed [4 + 2] Cyclization Reactions [0.03%]
N-杂环卡宾催化[4+2]环化反应手性2,2-二氟螺[茚-[1,3,4]噁二氮zin]-类化合物的不对称合成
Dan Li,Fen Gao,You-Quan Zhu et al.
Dan Li et al.
1,3,4-Oxadiazine derivatives represent an essential class of oxadiazine scaffolds that have demonstrated a wide spectrum of applications in modern drug discovery. However, the efficient and stereoselective construction of chiral 2,2-difluor...
Carolina Caso,Karl-Heinz Altmann
Carolina Caso
The synthesis of bis-macrolactam 5 as an advanced intermediate for the projected total synthesis of griseoviridin (1) has been achieved via intramolecular Suzuki-Miyaura coupling (>70% yield). Further key steps were the construction of the ...
Diastereoselective Cyclopropanation of Terminal, Nonconjugated Alkenes with 2-Oxoethylpyridinium Salts via Nucleopalladation [0.03%]
通过核 palladation 用 2-氧乙基吡啶盐对终端非共轭烯烃进行非对映选择性环丙烷化
Mandalaparthi Phanindrudu,Zhengzhi Wang,Ting Li et al.
Mandalaparthi Phanindrudu et al.
A highly diastereoselective Pd(II)-catalyzed cyclopropanation of terminal, nonconjugated alkenes using 2-oxoethylpyridinium salts as a "carbenoid" source is reported. An AQ-directed nucleopalladation reaction followed by oxidative ring clos...
Asymmetric Inverse-Electron-Demand Diels-Alder Reaction of 2-Pyrones with Acyclic Indolyl Alkenes for the Synthesis of Chiral N-Alkylindoles [0.03%]
内吲哚基烯烃与吡酮的不对称反电子需求狄尔斯-阿尔德反应合成手性N-烷基吲哚类化合物
Bin Chen,Long Cheng,Shuxuan Liu et al.
Bin Chen et al.
For the first time, this study employed a series of acyclic indolyl alkenes as dienophiles and successfully developed their inverse-electron-demand Diels-Alder (IEDDA) reactions with 2-pyrones, thereby constructing chiral N-alkylindole comp...
Yue Zhang,Weifeng Wang,Hongyun Li et al.
Yue Zhang et al.
Chemical protein synthesis by native amide ligation between two unprotected peptides provides an effective protocol. It is well-known that the development of a ligation method that is not limited by the sites of specific amino acids is high...
Light-Induced PdH-Catalyzed Cross-Dimerization of gem-Difluoroalkenes with Alkenes to Access CF2H Motifs [0.03%]
光促进的PdH催化gem-二氟烯烃与烯烃交叉二聚化反应构建CF2H基元
Luning Shen,Fen Wu,Dachang Bai et al.
Luning Shen et al.
The CF2H group constitutes a valuable structural motif in medicinal chemistry. Herein, we report an efficient light-induced palladium-catalyzed cross-dimerization of electron-deficient gem-difluoroalkenes with styrene derivatives, enabling ...
Synthesis of Chiral (hydro)Indoloquinazolinones via Enantioselective Copper-Catalyzed Borylative Cyclization [0.03%]
手性(hydro)吲哚喹唑啉酮的不对称铜催化环化硼化合成
Yaqi Zhang,Wei-Cong Liao,Tian-Ming Yang et al.
Yaqi Zhang et al.
An asymmetric copper-catalyzed borylative addition protocol enabling the synthesis of a series of chiral (hydro)indoloquinazoline heterocycles with high enantioselectivity (up to 98% ee) and moderate diastereoselectivity is reported here. T...
Photocatalytic Selective Synthesis of Hemiketals from Alkenes, α-Halo Acylarenes, and Water via N-Methylindole Catalysis [0.03%]
N-甲基吲哚催化烯烃、α-卤代芳酰氯和水选择性合成半缩酮的光催化的研究
Tao Ju,Zhi-Cheng Wei,Min Ge et al.
Tao Ju et al.
Herein, we report a visible-light-mediated N-methylindole-catalyzed difunctionalization of alkenes, enabling efficient and highly selective synthesis of five-membered hemiketals and polysubstituted tetrahydrofuran derivatives. In this trans...