Triplet Energy Transfer-Mediated Intermolecular Paternò-Büchi Reaction for the Synthesis of Trifluoromethylated Oxetanes [0.03%]
基于三重态能量转移的分子间Paterno-Buchi反应合成 trifluoromethylated oxetanes
Yining Zhu,Anthony J Fernandes,Egor Zhilin et al.
Yining Zhu et al.
Oxetanes are increasingly used as compact, polar carbonyl (bio)isosteres in drug discovery, and the combination with a trifluoromethyl group enables fine-tuning of molecular properties. Here, we report a visible-light-mediated Paternò-Büc...
Biotransformation of Allium Sulfur Metabolites by Proteus mirabilis Yields Cepathiosoxide, a Trithiabicyclic Sulfoxide [0.03%]
奇异变形链球菌转化Allium属硫代亚砜类化合物得到三噻杂双环二氧化硫衍生物-cepathiosoxide
Jaeyoun Lee,Yulseung Sung,Youngsang Nam et al.
Jaeyoun Lee et al.
Exposing onion-derived sulfur metabolites to Proteus mirabilis yielded cepathiosoxide, a structurally distinct trithiabicyclic sulfoxide formed through microbial biotransformation. LC-MS revealed the loss of native Allium tetrasulfides and ...
Scaling Azapeptide with N-Fmoc-Aza-Tripeptide from Resonant Acoustic Mixing of N-Fmoc-Amino Hydrazide and N-Succinimidyl Carbamate [0.03%]
通过共振声学混合N-Fmoc-氨基叠氮化合物和N-琥珀酰亚胺碳酸酯扩大azapeptide的合成范围：从N-Fmoc-aza-三肽开始
Michael Quagliata,Justin Desjardins-Michaud,Nassim Maarouf-Mesli et al.
Michael Quagliata et al.
Sustainable and scalable solution-phase synthesis of aza-tripeptide building-blocks was achieved by using resonant acoustic mixing (RAM). Hydrazinolysis gave N-(Fmoc)amino hydrazide without Fmoc cleavage, diacylation, epimerization, and chr...
Base-Promoted Denitrogenative Coupling of Nonactive 1,2,3-Triazoles with Ketones: Stereospecific Access to (Z)-β-Enaminones [0.03%]
以碱金属盐促进的酮与非活化1,2,3-三唑的去氮偶联反应：(Z)-β-烯胺酮的立体专一性合成
Shaofan Wang,Liguo Teng,Zhanhui Chen et al.
Shaofan Wang et al.
A base-promoted denitrogenative coupling of nonactive N(1)-aryl-1,2,3-triazoles with nucleophiles of ketones was developed, enabling the assembly of (Z)-β-enaminones at ambient temperature with complete stereoselectivity. Mechanistic studi...
Denitrogenative C-C and C-X Coupling Reactions of a Carbohydrate Tethered [1,2,3]Triazolo[1,5-a]pyrazine: Access to Chiral 2,5-Disubstituted Pyrazines as Potential Hypoglycemic Agents [0.03%]
基于糖类化合物的去氮性C-C和C-X偶联反应：用于合成具有降血糖潜力的手性2,5-取代哒嗪类化合物的新方法
Md Abu Zaid,Namakkal G Ramesh
Md Abu Zaid
A serendipitous base-mediated dehydrotosylation reaction accompanied by a concomitant aromaticity-driven ring opening of a carbohydrate fused 4,5,6,7-tetrahydro-[1,2,3]triazolo[1,5-a]pyrazine has led to the conceptualization of a novel rout...
PPh3-Catalyzed Remote Aminofluorination Reactions: Regioselective Access to γ- and ε-Fluoroamines Containing Oxindole [0.03%]
三磷苯基化物催化的远程氨氟化反应：含氧吲哚的γ-和ε-氟胺的选择性合成
Xing-Xing Dai,Wen-Hui Zhang,Xi-Ying Yang et al.
Xing-Xing Dai et al.
Remote aminofluorinations as a powerful strategy to synthesize 1,n-fluoroamines (n > 2) are of great significance and highly challenging. Herein, a remote 1,5-aminofluorination of spirovinylcyclopropyl oxindoles and N-fluorobenzenesulfonimi...
SCF3-Alkenes Unlocked: A Gateway via Cu(I)-Catalyzed Stereocontrolled Cross-Coupling [0.03%]
SCF3-烯烃解锁：通过Cu(I)催化立体控制交叉偶联进入通道
Logan Salamone,Xavier Vanderbiest,Olivier Riant
Logan Salamone
The SCF3 group has emerged as a key motif in medicinal and agrochemical chemistry. While synthetic methods to access aryl, alkynyl, and alkyl SCF3-derivatives are well-established, access to stereocontrolled SCF3-disubstituted alkenes remai...
Enantio- and Regioselective Access to Chiral α-Amino Ketones via Nickel/Photoredox Catalysis [0.03%]
镍/光氧化还原催化手性α-氨基酮的对映和区域选择性合成
Yuxi Tan,Hangyu Zhou,Dingyi Wang
Yuxi Tan
A novel nickelaphotoredox platform enables highly enantio- and regioselective carboacylation of alkenes with alkyl boronate salts and acyl chlorides for the modular asymmetric synthesis of α-amino ketone derivatives. This redox-neutral pro...
Dual-Activated Hydrocarboxylation of Acrylamides with Formate Salts via Radical-Radical Cross-Coupling [0.03%]
通过自由基-自由基交叉偶联，甲醛盐介导的丙烯酰胺双活化烃羧基化反应
Xin-Yue Wang,You-An Hao,Yu-Hang Li et al.
Xin-Yue Wang et al.
A novel dual-activation strategy for alkene hydrocarboxylation via radical-radical cross-coupling has been developed. This approach synchronously generates an alkenyl radical and CO2•-, favoring direct intermolecular coupling over cyclizat...
Zinc-Mediated Four-Component Carbonylation toward Direct Synthesis of α-Amino Ketones [0.03%]
锌介导的四组分羰基化反应直接合成α-氨基酮类化合物
Qiangwei Li,Xiao-Feng Wu
Qiangwei Li
α-Amino ketone plays an important role in medicinal chemistry due to its excellent multiple reaction sites, which serve as a chemical hub for constructing complex molecules. Moreover, its skeleton is also found in many bioactive molecules....