Diastereoselective Synthesis of Double Axially Chiral Indole Derivatives via Friedel-Crafts Biarylation [0.03%]
轴手性吲哚衍生物的双轴手性吲哚衍生物的高非对映选择性合成
Arijit Banerjee,Akanksha Yadav,Prasoon Raj Singh et al.
Arijit Banerjee et al.
We report a copper-catalyzed Friedel-Crafts biarylation protocol that delivers C3-site-selective doubly axially chiral biaryl indoles using five-membered cyclic diaryliodonium salts as biarylating agents. This atom-economical and highly dia...
Rhodium-Catalyzed [3+3] Annulation of N-Sulfonyl-1,2,3-triazole with a Homoallylic Alcohol for the Synthesis of 1,2-Dihydropyridine [0.03%]
铑催化N-磺酰基-1,2,3-三氮唑与 homoallylic 酒精的[3+3]环化反应合成1,2-二氢吡啶化合物
Palagulla Maheswar Reddy,Murugan Dhanalakshmi,Pazhamalai Anbarasan
Palagulla Maheswar Reddy
A general and efficient method for the synthesis of 1,2-dihydropyridine derivatives has been developed through the rhodium-catalyzed formal [3+3] annulation of N-sulfonyl-1,2,3-triazoles with homoallylic alcohols. The reaction demonstrates ...
Synthesis of C2-(N-Alkylcarbamoyl)-Substituted Pyrroles via Post-Condensation of Dipole Ugi Adducts [0.03%]
偶极Ugi加合物后缩合制备C2-(N-烷基碳酰胺)取代吡咯类化合物
Lei Chen,Tianjian Zhang,Rongxian Bai et al.
Lei Chen et al.
This work demonstrates that Dipole-Ugi-Adducts (DUAs) function as versatile, masked 1,3-dipolar synthons. Their structure incorporates two acid-labile protecting groups─an acetal and an amide-protected secondary amine─which sequentially r...
Zhenlei Zou,Yuntian Shi,Wangzhe Chen et al.
Zhenlei Zou et al.
The deoxyfluorination reaction has established itself as the most efficient methodology for direct fluorination, offering straightforward access to fluorinated compounds. In recent years, a number of deoxyfluorination reactions employing di...
Direct Access to Luminescent meta-Substituted Tris(2,4,6-trichlorophenyl)methyl Radicals through Nucleophilic Substitution [0.03%]
通过亲核取代直接获得发光的间位取代的三对氯苯基甲基自由基
Tingxi Yu,Ludi Wang,Zekun Tong et al.
Tingxi Yu et al.
We reported herein a facile synthetic strategy toward the preparation of mono- and di-meta-substituted tris(2,4,6-trichlorophenyl)methyl (TTM) radicals. The di- or tri-anion tris(2,4,6-trichlorophenyl)methane (HTTM) can act as nucleophiles,...
Regio- and Enantioselective Construction of C-N Axially Chiral N-Triazolyl-α-carbolines via Pyridine-Directed Click Reaction [0.03%]
基于吡啶导向的“点击反应”构建C-N轴手性N-三唑基-α-碳咻类化合物
Wei-Cong Liao,Yaqi Zhang,Long Jiang et al.
Wei-Cong Liao et al.
Herein, a pyridine-directed click asymmetric [3 + 2] cyclization of internal alkynes has been disclosed, enabling efficient access to C-N axially chiral 5,5-membered heterobiaryl atropisomers. The reaction affords a class of structurally no...
Total Synthesis of Acorane-Type Sesquiterpenes (±)-Bilaiaeacorenol B and (±)-Penicibilaenes A and B [0.03%]
全合成：（±）-Bilaiaeacorenol B和（±）-Penicibilaenes A和B
Qi-Qiong Yang,Xin-Yu Liu,Yun-Han Shang et al.
Qi-Qiong Yang et al.
The synthesis of acorane-type tricyclic sesquiterpenes (±)-bilaiaeacorenol B (1; R = H, X = OH) and (±)-penicibilaenes A (2; R = X = H) and B (3; R = Ac, X = H) is described. The strategy is chemically driven by bridgehead enone chemistry...
Discovery of Coracanols A and B, Two Biological Nitrification Inhibition Diterpenoids from Finger Millet [0.03%]
来源于 finger millet 中的两个生物硝化抑制倍半萜类化合物_corrachanol A 和B的研究
Junnosuke Otaka,Guntur Venkata Subbarao,Shigeki Matsumiya et al.
Junnosuke Otaka et al.
Natural products with biological nitrification inhibition (BNI) activity released from plant roots show potential for increasing the nitrogen-use efficiency and decreasing the extent of environmental pollution. We isolated two diterpenoids,...
Electrochemical C-H Phosphonylation of Indole with Phosphine Enabled by Chemoselective C-P Bond Cleavage [0.03%]
化学选择性C-P键断裂促进的磷化物介导的吲哚电化学脱氢磷酰化反应
Ting Wu,Zi-Hao Liao,Hao-Yue Xiang et al.
Ting Wu et al.
Given the significance of phosphonylated heterocycles, new phosphonylation pathways have been intensively pursued ever since. Herein, the electrochemical C3-C-H phosphonylation of indole with trivalent phosphine was accomplished, enabled by...
Truce-Smiles Rearrangement Cascade Enables Synthesis of Pyrazoline Derivatives [0.03%]
利用三氟乙酸催化的Truce-Smiles重排串联反应合成吡唑啉类化合物
Dengyuan Gao,Jiacheng Deng,Zhenguang Guo et al.
Dengyuan Gao et al.
A five-bond-forming cascade reaction for synthesizing pyrazoline derivatives is described. The transformation involves N-(arylsulfonyl) acrylamides and in situ generated Huisgen zwitterions from azodicarboxylates and triphenylphosphine unde...