Regio- and Enantioselective Construction of C-N Axially Chiral N-Triazolyl-α-carbolines via Pyridine-Directed Click Reaction
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Herein, a pyridine-directed click asymmetric [3 + 2] cyclization of internal alkynes has been disclosed, enabling efficient access to C-N axially chiral 5,5-membered heterobiaryl atropisomers. The reaction affords a class of structurally novel N-triazolyl-α-c... ...
