Combined Patch-clamp Electrophysiology and Single-Cell Genomic Analysis Reveal Spiking Tumor Cells at the Neocortical Glioblastoma Interface in Humans [0.03%]
结合补片夹 clamp 电生理学和单细胞基因组分析揭示人类新皮层胶质母细胞瘤界面的尖峰肿瘤细胞
Tong Tong,Josephine D Hendriksen,Kirstine J Elbæk et al.
Tong Tong et al.
Background: Electrophysiological features of glioblastoma cells (GBCs) remain largely elusive, challenging our comprehension of glioblastoma pathophysiology. Spiking GABAergic-OPC tumor cells were recently described in ID...
RAC1 Regulates SHH-Medulloblastoma Growth via GLI-Mediated Transcription [0.03%]
RAC1通过GLI介导的转录调控SHH型髓母细胞瘤生长
Nitish Jangde,Mi Hye Lee,Luz Ruiz et al.
Nitish Jangde et al.
Background: Medulloblastoma (MB) is the most common malignant brain tumor of childhood, and current treatments cannot sufficiently inhibit tumoral growth, leptomeningeal dissemination, and metastasis. RAC1, a low molecula...
RGS2 Promotes Brain Metastasis of Cisplatin-resistant Non-small Cell Lung Cancer through Caspase-1/IL-1beta Signaling Pathway [0.03%]
RGS2通过半胱天冬酶-1/白细胞介素-1β信号通路促进顺铂耐药非小细胞肺癌脑转移
Jiayi Lin,Lun Liang,Xupeng Zhu et al.
Jiayi Lin et al.
Background: Brain metastases are a leading cause of mortality in non-small cell lung cancer (NSCLC) patients. Chemoresistance-induced metastasis remains a significant challenge in NSCLC. This study investigates whether ci...
DNA Methylation Profiling Reveals a Novel Subtype Harboring IDH Mutation in H3-altered Gliomas [0.03%]
DNA甲基化谱分析揭示了组蛋白H3改变型胶质瘤中的一个新的亚型并带有IDH突变
Minjie Fu,Yuan Feng,Pin Sun et al.
Minjie Fu et al.
Background: H3-altered gliomas, now recognized by WHO CNS5 as grade 4 neoplasms driven by histone H3 mutations (notably H3K27M and H3G34R/V), exhibit marked molecular heterogeneity, dismal survival, and resistance to stan...
A dangerous chip off the old block promoting brain metastasis in inflammatory breast cancer [0.03%]
一种危险的炎症性乳腺癌脑转移促进程派生体
Benjamin Purow
Benjamin Purow
ONC206 demonstrates potent anti-tumorigenic activity and is a potential novel therapeutic strategy for high-risk medulloblastoma [0.03%]
ONC206展现出了强大的抑瘤活性，可能是高危髓母细胞瘤的一种新型的治疗策略
Theophilos Tzaridis,Jingbo Liu,Franklin Lee Chien et al.
Theophilos Tzaridis et al.
Background: Medulloblastoma is the most common malignant pediatric brain tumor, and has an urgent need for novel treatment approaches. Dordaviprone (ONC201) and its chemical derivative with nanomolar potency, ONC206, indu...
Evaluating "Brain Permeability": A Critical Issue for the Development of Therapeutic Agents for Primary and Metastatic Brain Tumors [0.03%]
评估“脑渗透性”：开发原发性和转移性脑肿瘤治疗药物的关键问题
Stuart A Grossman,Amy Barone,Roy E Strowd et al.
Stuart A Grossman et al.
Current assessments of brain permeability rely predominantly on drug delivery to contrast-enhancing tumor regions. However, substantial portions of central nervous system (CNS) tumors reside within non-enhancing brain (NEB), where drug conc...
Back to square one: Treatment for ependymoma in the post-ACNS0831 era [0.03%]
后退一步：儿童ependymoma治疗的现状及未来——ACNS0831后的思考
Jordan R Hansford,Vijay Ramaswamy,David D Eisenstat
Jordan R Hansford
Methodological Concerns on Overfitting in CSF Metabolomics Study of Leptomeningeal Metastasis [0.03%]
关于脑脊液代谢组学研究过度拟合的方法学关注点
Yaqin Zeng,Peng Sun
Yaqin Zeng
Chunhui Yang,Qi Wang
Chunhui Yang