The Genetics and Outcomes of an Altered FGF23-1,25D-PTH Axis in Diseases of Mineral Metabolism [0.03%]
FGF23-1,25D-PTH轴改变的遗传学和结局：矿质代谢疾病的证据
Emmanuel Solis,Kenneth E White,Mark B Meyer
Emmanuel Solis
The molecular mechanisms causing heritable disorders of hypo- and hyperphosphatemia involving the osteocyte-derived hormone fibroblast growth factor 23 (FGF23) and its co-receptor αKlotho (KL) have sprung new concepts underlying the endocr...
Contributions of Bone Microarchitecture to Skeletal Fragility in Adults with Longstanding Type 1 Diabetes [0.03%]
1型糖尿病成人骨骼脆弱的骨微结构特征分析
Lipi A Marion,Fjola Johannesdottir,Crystabella E Nevarez et al.
Lipi A Marion et al.
Type 1 diabetes mellitus (T1D) is associated with a marked increase in fracture risk, a phenomenon not entirely explained by lower DXA-BMD. Emerging evidence suggests T1D may adversely affect bone microarchitecture, though findings are inco...
From imaging to insight: biomechanical CT for fracture risk prediction [0.03%]
从影像到洞察：用于骨折风险预测的生物力学CT技术研究
Shengzhi Luan,Elise F Morgan
Shengzhi Luan
Remembering Steven Teitelbaum, scientist, physician, mentor, friend, and family man [0.03%]
缅怀斯蒂文·泰特尔鲍姆：科学家、医生、导师、朋友和家庭人
Deborah J Veis,Roberta Faccio
Deborah J Veis
Mechanisms Underlying the Waning of Osteoanabolic Therapy Effects in Osteoporosis [0.03%]
骨质疏松症抗骨吸收治疗效应衰退的机制研究
Serge Ferrari,Cyril Thouverey,Maude Gerbaix
Serge Ferrari
Osteoanabolic therapies such as parathyroid hormone (PTH) analogs (teriparatide, abaloparatide) and the sclerostin inhibitor romosozumab rapidly stimulate new bone deposition but their bone-building effects are not indefinite. Clinical tria...
Visceral adipose tissue is associated with changes in leptin, FGF-23 and vitamin D metabolism in chronic kidney disease [0.03%]
visceral脂肪组织与慢性肾脏疾病中瘦素、FGF-23和维生素D代谢变化有关
Rachel M Holden,Patrick A Norman,Mandy E Turner et al.
Rachel M Holden et al.
Leptin, a hormone produced by adipose tissue, stimulates bone production of FGF-23 in pre-clinical studies and thus may impact vitamin D metabolism. We investigated the association between longitudinal changes in visceral (VAT) and subcutan...
Recovery in bone mineral density following recent repeat pregnancy and breastfeeding among African women with and without HIV [0.03%]
非洲妇女在最近重复怀孕和哺乳后骨密度的恢复（有或没有HIV）
Flavia Matovu Kiweewa,Lara Lewis,Lynda Stranix-Chibanda et al.
Flavia Matovu Kiweewa et al.
Background: Women living with HIV (WLWH) in resource-limited settings have benefited greatly from antiretroviral therapy (ART). However, they have several risk factors that can affect their bone health including being fem...
Fractures at virtually all sites are associated with adverse outcomes: an observational study [0.03%]
几乎所有部位的骨折都与不良结局相关：一项观察性研究
Dima A Alajlouni,Dunia Alarkawi,Thach S Tran et al.
Dima A Alajlouni et al.
The FRAX model defines fractures occurring at the hip, vertebrae, humerus, and forearm as major osteoporotic fractures (MOF), leading to the misconception that fractures at other sites (NonMOF) are unimportant. We aimed to compare MOF and N...
Associations of Osteoporosis, Sarcopenia, and Osteosarcopenia With Mortality: A Comparative Analysis for Different Sarcopenia Definitions in the Manitoba and NHANES Populations [0.03%]
骨质疏松、肌少症和肌骨质疏松与死亡率的关系：不同肌少症定义在曼尼托巴和NHANES人群中的比较分析
Xinwei Wang,William D Leslie,Lisa M Lix et al.
Xinwei Wang et al.
Osteosarcopenia is a major public health concern, but its association with mortality, remains understudied. We aimed to examine the associations between osteoporosis, sarcopenia, and osteosarcopenia with mortality. We used two populations: ...
Predicting Fracture Risk After Non-Recent High Risk Fracture: Improving accuracy with simple modifiers to FRAX [0.03%]
使用简单的修正方法结合FRAX预测非近期高风险骨折后的骨折风险改善准确性
Carrie Ye,Suzanne N Morin,Lisa M Lix et al.
Carrie Ye et al.
Prior fracture is among the strongest predictors of future osteoporotic fracture. However, the Fracture Risk Assessment Tool (FRAX®) incorporates it as a dichotomous variable, potentially obscuring important heterogeneity related to fractu...