Suppression of early pro-inflammatory senescent signature post-radiotherapy mitigates chronic bone damage [0.03%]
抑制放射治疗后的早期促炎衰老标志物可缓解慢性骨损伤
David Achudhan,Jacob Orme,Ritika Sharma et al.
David Achudhan et al.
Cellular senescence has been implicated in the pathophysiology of radiotherapy-associated bone loss. Based on our previous work, clearance of senescent cells using genetic and pharmacological tools alleviates the anomalies associated with r...
One axis, two skeletal fates - PD-L1 blockade spares bone where PD-1 blockade does not. Editorial on Searcy et al. "Programmed cell death ligand 1 (PD-L1) inhibition in tumor-naïve mice is bone-sparing throughout the lifespan" [0.03%]
同一轴，两种骨骼命运——PD-L1阻断可保骨，而PD-1阻断则不能。关于Searcy等人的评论：“在无肿瘤的小鼠中程序性细胞死亡配体1（PD-L1）抑制剂终生保骨”
Hanna Taipaleenmäki
Hanna Taipaleenmäki
Bone Microarchitecture and Mechanical Competence Are Associated with Fracture Across Race and Sex in Older Adults [0.03%]
骨微结构和机械性能与老年人骨折的关系（不分种族和性别）
Ragyie Rawal,Sanchita Agarwal,Carmen Germosen et al.
Ragyie Rawal et al.
Studies evaluating skeletal differences by fracture status used predominantly White female cohorts with limited data in other races and men. Using high-resolution peripheral quantitative CT and microfinite element analysis, we compared skel...
Parental History of Hip Fracture is Associated with Trabecular Deterioration [0.03%]
父母髋部骨折史与 trabecular 退化有关
Sanchita Agarwal,Ragyie Rawal,Carmen Germosen et al.
Sanchita Agarwal et al.
Parental history of hip fracture is an independent risk factor for fragility fracture, yet the skeletal traits underlying this risk remain poorly defined. We examined whether parental hip fracture is associated with differences in bone micr...
Twenty-four-hour movement composition is associated with HR-pQCT bone strength in older adults: The Study of Muscle, Mobility and Aging (SOMMA) [0.03%]
24小时运动模式与老年人HR-pQCT骨强度相关：肌力、 mobility 和 aging 研究(SOMMA)
Lauren S Roe,Nina Z Heilmann,Reagan E Garcia et al.
Lauren S Roe et al.
Time in moderate-to-vigorous intensity activity (MVPA), light intensity activity (LPA), and sleep are critical for bone health in older adults but are often considered separately despite being inherently co-dependent. We examined cross-sect...
Accelerated osteocytic citrate production in chronic kidney disease is associated with protection of the kidney [0.03%]
慢性肾脏病中加速的骨细胞柠檬酸产生与肾脏保护有关
Jie Ren Gerald Har,Maggie Yun-Hsuan Hsu,Keith L Saum et al.
Jie Ren Gerald Har et al.
Metabolites mediate inter-organ communication and this metabolic crosstalk often goes awry in systemic diseases, including chronic kidney disease-mineral bone disorder (CKD-MBD), where CKD disrupts skeletal homeostasis, with significant bon...
Osteoarthritis risk associated with denosumab in adults with osteoporosis: A target trial emulation [0.03%]
成人骨质疏松症患者使用denosumab与骨关节炎风险的相关性：靶向试验模拟研究
Masaki Hatano,Yuya Kimura,Akira Okada et al.
Masaki Hatano et al.
Denosumab, a well-established osteoporosis treatment, has demonstrated potential bone- and cartilage-protective effects in preclinical and early trials. However, it remains unclear whether these promising findings extend to osteoarthritis p...