Validating Fracture Risk After Stoke: A Call to Action to Optimize Skeletal Health After Stroke? [0.03%]
卒中后骨折风险的验证：优化卒中后的骨骼健康的行动呼吁？
Robert A Wermers
Robert A Wermers
Markers and regulators of osteoblast and osteoclast activity in children with X-linked hypophosphatemia treated with burosumab [0.03%]
Ineke Böckmann,Maren Leifheit-Nestler,Mirko Rehberg et al.
Ineke Böckmann et al.
Burosumab is effective for treatment of rickets in children with X-linked hypophosphatemia (XLH). The effects of burosumab on markers and regulators of osteoblast and osteoclast acitivity are largely unknown. In this cross-sectional observa...
Immune Checkpoint Inhibitors and Fracture Risk: A Systematic Literature Review and Pooled and Meta-Analysis of Randomized Controlled Trials [0.03%]
免疫检查点抑制剂与骨折风险：系统文献回顾及随机对照试验的汇总和荟萃分析
Manar Elsayed,Brianna Greenwood,Xiaoming Wang et al.
Manar Elsayed et al.
Immune checkpoint inhibitors (ICIs) are indicated for numerous malignancies, but may have off-target effects called immune-related adverse events (irAEs). Fractures are not considered irAEs, but ICIs may promote osteoclast activation, leadi...
Precision and age-related changes of 3D-DXA reconstructions and FEA of the proximal femur in comparison to DXA [0.03%]
三维重建和有限元分析与双能X线吸收法的精准度及年龄相关性变化对比——股骨近端模型研究
Yvan Gugler,Daniela A Frauchiger,Kurt Lippuner et al.
Yvan Gugler et al.
The growing interest in 3D-DXA reconstructions for possible uses in fracture risk prediction or patient follow-up, e.g., in conjunction with finite element analyses, asks for precision data to increase the interpretability of results making...
Complex clinical encounter series: Glucagon-like peptide-1 receptor agonists-induced weight loss: are we paying attention to bone health? [0.03%]
复杂临床病例系列：胰高血糖素样肽-1受体激动剂诱导的体重减轻：我们注意到了骨骼健康吗？
Elena Ambrogini
Elena Ambrogini
A sixty-five-year-old white woman with obesity class II, hypertension, hyperlipidemia, obstructive sleep apnea, osteoarthritis, and pre-diabetes was started on subcutaneous semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA),...
Asian ethnicity is associated with shorter anti-resorptive exposure prior to atypical femur fracture (AFF): a Transcontinental Atypical Femoral Fracture Consortium (TrAFFiC) cohort study [0.03%]
亚洲人种在不典型股骨骨折(AFF)之前抗吸收疗法暴露时间较短：来自跨洲不典型股骨骨折联盟(TrAFFiC)队列研究的结果
Lucy Collins,Cat Shore-Lorenti,Colin Chen et al.
Lucy Collins et al.
Osteoporosis prevalence is expected to increase with global ageing. Bisphosphonates and denosumab are effective treatments, but anxiety regarding safety concerns, medication-related osteonecrosis of the jaw and atypical femur fractures (AFF...
Weekend Warrior Physical Activity Pattern, Metabolomic Profiles, and Risk of Osteoporosis and Fracture [0.03%]
周末战士型身体活动模式、代谢组学特征及其与骨质疏松和骨折风险的关系
Huan Huang,Jiong Liu,Peixuan Li et al.
Huan Huang et al.
Background & aims: The weekend warrior pattern, characterized by infrequent but sufficient bouts of moderate-to-vigorous physical activity (MVPA), has become increasingly common. Its association with the risk of osteoporo...
Cost-savings from fracture prevention with zoledronate in randomised controlled trials [0.03%]
唑来膦酸预防骨折的成本效益：随机对照研究结果
Mark J Bolland,Andrew Grey,Ian R Reid
Mark J Bolland
Zoledronate prevented fractures in four large trials in cohorts that varied from low to high risk of fracture. Cost-effectiveness analyses are important tools used in funding and regulatory decisions about pharmaceutical agents, and zoledro...
Validating the FRAC-Stroke score: targeting those at highest risk of fracture [0.03%]
验证FRAC-卒中评分：针对骨折高危人群
Gabrielle Stokes,Anne Trinh,Nadine E Andrew et al.
Gabrielle Stokes et al.
Background: Fracture risk is increased after stroke, but there is a lack of specific, effective tools to screen and prevent minimal trauma fractures (MTF) post-stroke. While the FRAC-Stroke score, developed to predict fra...