Immune Checkpoint Inhibitors and Fracture Risk: A Systematic Literature Review and Pooled and Meta-Analysis of Randomized Controlled Trials
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Immune checkpoint inhibitors (ICIs) are indicated for numerous malignancies, but may have off-target effects called immune-related adverse events (irAEs). Fractures are not considered irAEs, but ICIs may promote osteoclast activation, leading to fractures. Thi... ...
