Sustained Improvement in Renal Function with Palopegteriparatide in Adults with Chronic Hypoparathyroidism: 2-Year Results from the Phase 3 PaTHway-Trial [0.03%]
成人慢性甲状旁腺功能减退症患者的帕洛特佩治疗可长期改善肾功能：PATHway研究的两年期结果
Lars Rejnmark,Elvira O Gosmanova,Aliya A Khan et al.
Lars Rejnmark et al.
The PaTHway clinical trial demonstrated sustained efficacy, safety, and tolerability of daily palopegteriparatide in the treatment of adults with hypoparathyroidism. Palopegteriparatide treatment was also associated with improvements in eGF...
Palopegteriparatide Therapy for Hypoparathyroidism: Targeting the PTH Receptor Rouses the Sleeping Skeleton [0.03%]
靶向PTH受体唤醒“沉睡的骨骼”——低血钙患者的新疗法
Michael A Levine
Michael A Levine
Intratrabecular bone remodeling - a previously overlooked mode of remodeling hyperactivated by parathyroid hormone [0.03%]
trabecula内的骨重建-一种此前被忽视的由甲状旁腺激素过度激活的重建方式
Lisbeth Koch Thomsen,Kaja Søndergaard Laursen,Tanja Sikjær et al.
Lisbeth Koch Thomsen et al.
Currently, no consensus exists on either terminology, definition, or the biological significance of the phenomena intratrabecular tunneling. Despite this, observations of intratrabecular tunneling are frequently reported in literature cover...
Sex-specific bone architectural deficits among older adults living with HIV: a cross-sectional study from Zimbabwe [0.03%]
津巴布韦一项横断面研究：HIV感染老年人骨形态性别特异性缺陷
Mícheál Ó Breasail,Kate A Ward,Tadios Manyanga et al.
Mícheál Ó Breasail et al.
People with HIV (PLWH) are living longer with antiretroviral therapy (ART) but HIV increases the risk of age-associated diseases including osteoporosis. A cross-sectional study of men and women ≥40 years was conducted in Harare, Zimbabwe. ...
Nelson B Watts
Nelson B Watts
A case is discussed of a postmenopausal woman started on alendronate treatment based on a low T-score in the total hip. 3 yr later, her total hip score remains below -2.5, the target set by the ASBMR task force on goal-directed therapy.(1) ...
Different Lrp5-HBM mutations induce magnitude- and surface-selective effects that are not explained by receptor trafficking [0.03%]
不同的Lrp5-HBM突变诱导幅度和表面选择性效应并非由受体转运解释
Kyung-Eun Lim,Whitney A Bullock,April M Hoggatt et al.
Kyung-Eun Lim et al.
The Wnt co-receptor LRP5 plays a crucial role in skeletal physiology. Homozygous loss-of-function mutations in the Lrp5 gene produce severe osteopenia, whereas certain heterozygous point mutations produce extreme high bone mass (HBM). Diffe...
Geometry of the proximal femur during growth and its contribution to childhood fractures in healthy children [0.03%]
健康儿童股骨近端生长的几何学及其对儿童骨折的影响
Babette S Zemel,Jonathan A Mitchell,Andrea Kelly et al.
Babette S Zemel et al.
Hip structural analysis (HSA) of proximal femur scans by dual energy X-ray absorptiometry estimates hip geometry and structural strength, but little is known about how these parameters change during peak bone mass development. We describe a...
Mechanical loading-induced bone formation is associated with increased blood velocity and vascular canal bone porosity, with localized vascular adaptation [0.03%]
机械荷载诱导的骨形成与血液流速增加和血管通道骨孔隙度增大以及局部血管适应性有关
Taylor deVet,Mahmoud S Moussa,Hanna Gonzalez et al.
Taylor deVet et al.
Bone is a highly vascularized tissue, which is required for the metabolically demanding process of remodeling. Blood vessels are important in fluid movement occurring during bone mechanoadaptation. We hypothesized that in-vivo mouse tibial ...
Journal of Bone and Mineral Research (JBMR) 40th anniversary celebration: the third decade (part 2) [0.03%]
骨矿研究杂志(JBMR)四十周年庆典：第三个十年（第二部分）
Juliet E Compston
Juliet E Compston
HR-pQCT skeletal phenotype clustering associated with muscle function in older men and women: The Study of Muscle, Mobility and Aging (SOMMA) [0.03%]
与老年男女肌肉功能相关的HR-pQCT骨骼表型聚类：肌力、行动和老龄化研究（SOMMA）
Morgan W Bolger,Kerri S Freeland,Megan M Marron et al.
Morgan W Bolger et al.
Age-related changes to BMD, morphometry, and microarchitecture do not occur uniformly across the population and the common skeletal phenotypes beyond BMD are not well defined. Additionally, the associations between bone and muscle are criti...