Different Lrp5-HBM mutations induce magnitude- and surface-selective effects that are not explained by receptor trafficking
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The Wnt co-receptor LRP5 plays a crucial role in skeletal physiology. Homozygous loss-of-function mutations in the Lrp5 gene produce severe osteopenia, whereas certain heterozygous point mutations produce extreme high bone mass (HBM). Different HBM-causing mis... ...
