Circulating Neurodegenerative Brain Injury Markers and Hip Fracture and Fall Hospitalizations: The Cardiovascular Health Study (CHS) [0.03%]
循环神经退行性脑损伤标志物与髋部骨折和跌倒住院的关系：心血管健康研究（CHS）
Jane A Cauley,Petra Buzkova,Howard A Fink et al.
Jane A Cauley et al.
Individuals with dementia have a heightened hip fracture and fall risk but whether markers of brain injury are associated with hip fracture and falls is unknown. We tested the hypothesis that higher circulating brain injury markers were ass...
Severe early-onset osteoporosis due to heterozygous WNT1 variants in adults: a clinical and therapeutic challenge [0.03%]
成人杂合WNT1变异严重性早期骨质疏松的临床和治疗挑战
E M Ryhänen,R E Mäkitie,T Pekkarinen et al.
E M Ryhänen et al.
ENPP1 Inhibition: A Promising Oral Therapy for Later-Onset Hypophosphatasia [0.03%]
口服 ENPP1 抑制剂有望成为治疗晚发型低磷血症性成骨不全的新方法
Vicky E MacRae
Vicky E MacRae
Comparative Bone Histomorphometry Effects of Combined Denosumab and Teriparatide versus Monotherapy in Postmenopausal Women with Osteoporosis: A Randomized Controlled Trial [0.03%]
绝经后骨质疏松妇女联合应用狄诺塞麦和特立帕肽与单药治疗的比较骨骼生物力学效应：随机对照试验
Sabashini K Ramchand,Joy N Tsai,Yingshe Zhao et al.
Sabashini K Ramchand et al.
Combined treatment with parathyroid hormone (PTH) receptor stimulation (teriparatide 20-μg) and RANKL inhibition (denosumab 60-mg) increases spine and hip bone mineral density (BMD) and improves estimates of bone strength to a greater exte...
Salvatore Minisola,Luciano Colangelo,Jessica Pepe et al.
Salvatore Minisola et al.
Tumor-induced osteomalacia (TIO) is an ultrarare paraneoplastic syndrome of abnormal phosphate and vitamin D metabolism secondary to the overproduction of fibroblast growth factor 23 by small-sized mesenchymal tumors typically located in so...
The gSOS Polygenic Score is Associated with Bone Density and Fracture Risk in Childhood [0.03%]
儿童骨骼密度和骨折风险与gSOS多基因评分相关
Jonathan A Mitchell,Jonathan Bradfield,Shana E McCormack et al.
Jonathan A Mitchell et al.
The polygenic risk score genetic quantitative ultrasound speed of sound (gSOS) was developed using machine learning algorithms in adults of European ancestry and associates with reduced odds of fracture in adults. We aimed to determine if g...
Constitutive activation of ALK3 in chondrocytes exacerbates skeletal dysplasia in mice with Achondroplasia [0.03%]
ALK3的组成型激活可加重小鼠Achondroplasia的症状
Min Jin,Hangang Chen,Huabing Qi et al.
Min Jin et al.
Achondroplasia (ACH), the most common skeletal dysplasia in humans, is caused by gain-of-function mutations in fibroblast growth factor receptor 3 (FGFR3). Activation of FGFR3 and its downstream signaling pathways lead to disturbed chondrog...
Validation of a Polygenic Score for Bone Health-Related Outcomes in Childhood [0.03%]
儿童骨健康相关结局多基因评分的验证
Melissa Fiscaletti,Despoina Manousaki
Melissa Fiscaletti