Constitutive activation of ALK3 in chondrocytes exacerbates skeletal dysplasia in mice with Achondroplasia
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Achondroplasia (ACH), the most common skeletal dysplasia in humans, is caused by gain-of-function mutations in fibroblast growth factor receptor 3 (FGFR3). Activation of FGFR3 and its downstream signaling pathways lead to disturbed chondrogenesis in achondropl... ...
