SESN2 Drives Osteoarthritis Progression by Inducing MFN2-Dependent Mitochondrial Hyperfusion in Rats [0.03%]
SESН2通过诱导MFN2依赖的线粒体过度融合驱动大鼠骨关节炎进展
Yiwen Zhang,Zehang Zheng,Wenjie Hou et al.
Yiwen Zhang et al.
Objective: This study aimed to elucidate the role of SESN2 in the pathological process of osteoarthritis (OA), with a particular focus on its potential mechanism in regulating chondrocyte mitochondrial function. ...
OA Fundamentals Series: DIAGNOSIS AND CLINICAL ASSESSMENT OF OSTEOARTHRITIS [0.03%]
OA基础系列：骨关节炎的诊断与临床评估
Lauren K King,Abhishek Abhishek
Lauren K King
Objective: Osteoarthritis (OA), the most common form of arthritis, is a heterogenous condition with substantial variability in clinical presentation. Despite its high prevalence, OA is frequently underdiagnosed and inadeq...
Deciphering the RSPO3-NFATC1 Switch in the Bone-Cartilage Paradox: Genetic Liability to Osteoporosis Protects Against Osteoarthritis by Modulating Subchondral Bone Compliance [0.03%]
破解RSPO3-NFATC1转换在骨软骨悖论中的作用：通过调节软骨下骨顺应性，遗传易感性降低骨质疏松症风险并保护免受骨关节炎侵害
Lei Peng,Jinliang Wei,Haoran Yang et al.
Lei Peng et al.
Background: The clinical "bone-cartilage paradox" between osteoporosis (OP) and osteoarthritis (OA) remains controversial. Deciphering their causal link and underlying molecular switches is crucial for the integrated mana...
GDF10 Attenuates Chondral Fibrosis and Cartilage Degeneration in Osteonecrosis of the Femoral Head: Insight into Underlying Regulatory Mechanisms [0.03%]
GDF10缓解股骨头坏死中的软骨纤维化和软骨退变：潜在调节机制的见解
Yingkang Zhu,Wang Wei,Xu Wang et al.
Yingkang Zhu et al.
Objective: Osteonecrosis of the femoral head-associated cartilage degeneration (ONFH-ACD) is characterized by fibrocartilaginous remodeling, loss of hyaline matrix, and mechanical impairment, but its regulatory mechanisms...
A Multi-Switch Mechanism Underlying Mechanical Force Regulation of Aggrecan Degradation in Osteoarthritic Cartilage [0.03%]
软骨基质 aggrecan 蛋白多聚化调控的分子机制研究取得进展
Yen-Yu Lai,Shu-Wei Chang
Yen-Yu Lai
Objective: To elucidate the molecular mechanism by which mechanical forces regulate aggrecan degradation in osteoarthritic cartilage. Design: ...
Rethinking Meniscal Ossicles as Imaging Biomarkers for Meniscal Turnover, Overload, and Pathology in Pre-clinical Knee Osteoarthritis Research [0.03%]
重塑半月板骨化作为影像生物标志物以表征临床前膝关节骨性关节炎研究中的半月板周转、超载和病变
Aurea Mohana-Borges,Laxshmi Veda Avula,Sanique M South et al.
Aurea Mohana-Borges et al.
Objective: Despite widespread use of mouse osteoarthritis models, meniscal ossicles (MOs), a distinct feature of murine meniscus, remain incompletely characterized. This study aimed to detail MO morphology and bone featur...
Radiomics Grading of Hand Osteoarthritis Severity Using Standard Radiographs: Results from the DIGICOD Cohort [0.03%]
基于标准X线片的手部骨关节炎放射组学分级：DIGICOD队列研究结果
Laetitia Perronne,Antoine Decoux,Loïc Duron et al.
Laetitia Perronne et al.
Objective: This study evaluated whether radiomics analysis of standard hand radiographs could provide an automated and objective assessment of structural severity in hand osteoarthritis (HOA) compared to Kellgren-Lawrence...
Improving comparability of microCT assessment and reporting of subchondral bone in mouse models of osteoarthritis [0.03%]
提高小鼠骨关节炎模型下软骨骨微CT评估和报告的可比性
Pholpat Durongbhan,Lucinda A E Evans,David M Findlay et al.
Pholpat Durongbhan et al.
Objective: Subchondral bone is a critical component of the osteochondral unit, but its translation from histology to quantitative imaging studies using micro-computed tomography (microCT) remains inconsistent. Definitions...
Genetics of osteoarthritis: Insights from GWAS to therapeutic opportunities [0.03%]
遗传学在骨关节炎中的作用：从GWAS到治疗机遇的见解
Konstantinos Hatzikotoulas,Lorraine Southam,Eleftheria Zeggini
Konstantinos Hatzikotoulas
Objective: Osteoarthritis is the most common joint disease and a leading cause of pain and disability worldwide, affecting both weight-bearing and non-weight-bearing joints. Osteoarthritis is a complex polygenic disease s...