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Deciphering the RSPO3-NFATC1 Switch in the Bone-Cartilage Paradox: Genetic Liability to Osteoporosis Protects Against Osteoarthritis by Modulating Subchondral Bone Compliance

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Background: The clinical "bone-cartilage paradox" between osteoporosis (OP) and osteoarthritis (OA) remains controversial. Deciphering their causal link and underlying molecular switches is crucial for the integrated management... ...