Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size [0.03%]
UBR框E3泛素连接酶和蛋白质质量控制通路对蛋白质合成及骨骼肌大小变化的响应机制研究
Leslie M Baehr,Luis Gustavo Oliveira de Sousa,Craig A Goodman et al.
Leslie M Baehr et al.
The N-degron pathway contributes to proteolysis by targeting N-terminal residues of destabilized proteins via E3 ligases that contain a UBR-box domain. Emerging evidence suggests the UBR-box family of E3 ubiquitin ligases (UBR1-7) are invol...
Host-microbiota interactions regulate gut serotonergic signaling and implications for hypertension [0.03%]
宿主微生物互作调控肠脑轴血清素信号及对高血压的影响机制研究
Hemaa Sree Kumar,Jasenka Zubcevic
Hemaa Sree Kumar
Serotonin (5-hydroxytryptamine) is a highly conserved signaling molecule present across diverse taxa, including plants, invertebrates, and vertebrates. In mammals, the majority of peripheral serotonin is synthesized in the gastrointestinal ...
Exercise decreases the number and modifies the transcriptome of M1 macrophages and CD8+ T cells in non-occluded epicardial adipose tissue of female pigs [0.03%]
运动减少并修改了雌性猪非阻塞心外膜脂肪组织中M1巨噬细胞和CD8+t细胞的数量和转录组
Irshad Ahmad,Shreyan Gupta,Micah Thomas et al.
Irshad Ahmad et al.
Epicardial adipose tissue (EAT) regulates lipid metabolism and immune cell recruitment in coronary arteries. Increased EAT contributes to coronary artery disease (CAD), but exercise prevents CAD. We hypothesized that exercise, irrespective ...
A tough job: Ion channels, transporters, and pumps during organ fibrosis [0.03%]
艰难的工作：器官纤维化过程中的离子通道、转运蛋白和泵
Weronika Wilczak,Rieke Schleinhege,Christine Loescher et al.
Weronika Wilczak et al.
Fibrosis plays a crucial role in a range of chronic diseases, including cancer. Emerging evidence suggests that ion channels, transporters, and pumps - the transportome - have an essential share in fibrogenesis and fibrosis by regulating fi...
Luigi Regenburgh De La Motte,Barbara Bassani,Francesco Trepiccione et al.
Luigi Regenburgh De La Motte et al.
The prevalence of heart failure (HF) and of chronic kidney disease (CKD) is continuously rising. Both diseases require significant management efforts, and more importantly, HF is often associated with CKD, aggravating the clinical scenario ...
Glycolytic metabolism and biomass production from glucose in human skeletal muscle growth [0.03%]
人类骨骼肌生长过程中糖酵解代谢和葡萄糖生物量生成的关系
Sakari Mäntyselkä,Marco Ahvenlammi,Jennika Vartiainen et al.
Sakari Mäntyselkä et al.
Skeletal muscle is the main consumer of glucose after a mixed meal, and resistance exercise further increases muscle glucose uptake. Emerging evidence suggests that glucose uptake in muscles is not only stored as glycogen or used as a fuel ...
Activation of the Piezo1 channel stimulates protein kinase D and migration in human aortic endothelial cells [0.03%]
活化的Piezo1通道刺激人的主动脉内皮细胞中的蛋白激酶D和迁移现象
Moien Lone,Parvind Singh,James Sinnett-Smith et al.
Moien Lone et al.
Piezo 1 is an evolutionally conserved mechanosensitive ion channel implicated in the regulation of development, differentiation, and growth of multiple tissues. Despite its importance, the pathways induced downstream of Piezo1 activation re...
Activation of Smo/Gli1 pathway attenuates cardiac fibrosis by suppressing G1 / S phase transition and cell proliferation in cardiac fibroblasts in mice [0.03%]
SMO/GLI1信号通路通过抑制心脏成纤维细胞G1/S期转换和细胞增殖来缓解小鼠心脏纤维化激活
Qi Xiong,Liying Yang,Changqing Peng et al.
Qi Xiong et al.
Cardiac fibrosis is the activation of cardiac fibroblasts (CFs) and deposition of extracellular matrix caused by various injurious factors, which affects cardiac function and structure and ultimately leads to the development of heart failur...
NADPH Oxidase 1 (NOX1)-PKCδ-dependent ZO-1 phosphorylation mediates IL-33-induced inner blood-retinal barrier disruption in proliferative retinopathies [0.03%]
NADPH氧化酶1（NOX1）-PKCδ依赖的ZO-1磷酸化介导IL-33诱导的增殖性视网膜病内屏障破坏
Geetika Kaur,Shivantika Bisen,Anamika Sharma et al.
Geetika Kaur et al.
Proliferative retinopathies are associated with abnormal angiogenesis that can result in visual impairment or vision loss. The tight junction complex regulates blood-retinal barrier integrity; however, its role in proliferative retinopathie...
Skeletal Muscle Alterations and Functional Repercussions in Patients with Colorectal Cancer-associated Cachexia [0.03%]
结直肠癌恶病质患者的骨骼肌改变及功能影响
Britt van de Haterd,Michèlle Hendriks,Bert Houben et al.
Britt van de Haterd et al.
Cancer cachexia causes skeletal muscle wasting and metabolic dysfunction, worsening clinical outcomes in colorectal cancer (CRC). This study examines microscopic and macroscopic skeletal muscle fiber characteristics, and muscle volume in ca...