Mitochondrial DNA in necrosis-like cell death in failing hearts: evidence and mechanisms fostering damage [0.03%]
心力衰竭中类似细胞坏死中的线粒体DNA：促进损伤的证据和机制
Andrea Marciníková,Izabela Jarabicová,Csaba Horváth et al.
Andrea Marciníková et al.
Mitochondrial DNA (mtDNA) is increasingly recognized as a damage-associated molecular pattern (DAMP) that signals mitochondrial injury and the consequent pro-death molecular signature. Such mtDNA release triggers programmed necrotic pathway...
Exogenous lactate ameliorates Aβ-induced energy deficit and neurotoxicity with increased mitochondrial TCA cycle carbon flux in SH-SY5Y cells [0.03%]
外源乳酸通过增加SH-SY5Y细胞线粒体TCA循环生物发生率缓解Aβ诱导的能量不足和神经毒性作用
Yewon Chang,Hee-Joo Kim,Yeongmin Kim et al.
Yewon Chang et al.
A growing body of evidence has demonstrated the existence of metabolic dysfunction in neurodegenerative diseases, including Alzheimer's disease (AD), suggesting that deprivation of energy substrates impairs cellular dynamics. As glucose uti...
AMITO: an open-access application for assisted analysis of mitochondria in transmission electron microscopy images [0.03%]
AMITO：一个开放访问的应用程序，用于透射电子显微镜图像中线粒体分析的辅助分析
Elyse Hucteau,Thomas J Hureau,Allan F Pagano et al.
Elyse Hucteau et al.
Analysis of mitochondrial morphology and ultrastructure from transmission electron microscopy images is essential for understanding cellular adaptations in both physiological and pathological conditions. However, these investigations remain...
β1-Adrenergic antagonist monotherapy of male rabbits with ischemic HFrEF reverses sarcolemmal Na+-K+ pump inhibition and reduces lung congestion [0.03%]
β1-肾上腺素受体拮抗剂单药治疗雄性缺血性HFrEF兔可逆转肌膜钠钾泵抑制并减少肺淤血
Natasha A S Fry,Chia-Chi Liu,Alvaro Garcia et al.
Natasha A S Fry et al.
Cotreatment with angiotensin-converting enzyme (ACE) inhibitors/angiotensin II receptor antagonists was obligatory, and an aldosterone antagonist was optional, in trials that established the efficacy of β1-adrenergic receptor (β1AR) antag...
Insulin-regulated actin dynamics is disrupted in a human keratinocyte model of Hailey-Hailey disease [0.03%]
胰岛素调节的肌动蛋白动力学在Hailey-Hailey病的人类角质形成细胞模型中被破坏
Ruby Gupta,Akash Chinchole,Ngozi P Paul et al.
Ruby Gupta et al.
The secretory pathway Ca2+-ATPase, SPCA1 (gene name ATP2C1), is a Golgi-localized calcium pump defective in the autosomal dominant cutaneous disorder known as Hailey-Hailey disease (HHD). Although clinically well characterized by suprabasal...
Lipin1 restores nNOS sarcolemmal localization and improves fatigue resistance in Duchenne muscular dystrophy [0.03%]
lipin 1恢复nnos肌膜定位并改善杜氏肌营养不良的疲劳耐受力
Ayat Azzam,Abdulrahman Jama,John Karanja Kamau et al.
Ayat Azzam et al.
In Duchenne muscular dystrophy (DMD), neuronal nitric oxide synthase (nNOS) is mislocalized from the sarcolemmal membrane and exhibits reduced expression and activity, impairing vasomodulation and contributing to increased muscle fatigue. I...
O2-sensing and HIF regulation: from oxygen homeostasis to tumor-associated immune responses [0.03%]
氧感应与HIF调节：从氧稳态到肿瘤相关免疫反应
Vivienne Schneider,Joachim Fandrey,Sandra Winning
Vivienne Schneider
Oxygen is needed to generate adenosine triphosphate (ATP) via aerobic respiration in mitochondria. Hypoxia-when the tissue's oxygen demand exceeds its supply-characterizes not only sites of acute inflammation but also many tumors and their ...
Human M1-macrophages secrete glutamine: a role for the transporters ASCT2 and SNAT5 [0.03%]
人M1-巨噬细胞分泌谷氨酰胺：ASCT2和SNAT5运输体的作用
Giuseppe Taurino,Martina Chiu,Chiara Ughini et al.
Giuseppe Taurino et al.
Previous results indicated that LPS treatment of human macrophages is associated with the induction of glutamate-ammonia-ligase (GLUL)GLUL, the enzyme that synthesizes glutamine, although the effects on cell Gln level were not assessed by t...
Polymeric nanoparticle-mediated siRNA delivery into primary human bronchial airway cells [0.03%]
聚乙二醇化的树枝状介导siRNA进入人支气管上皮细胞
Michael A Thompson,Samantha K Hamrick,Niyati A Borkar et al.
Michael A Thompson et al.
Small interfering RNAs (siRNA) are powerful tools to target cellular protein expression, making them promising candidates for therapeutic applications. siRNA-based approaches to target detrimental mechanisms in airway diseases such as asthm...
Hypoxic eNOS uncoupling as a consequence of DHFR downregulation in various human endothelial cell lines - the crucial role of the BH4 regeneration pathway [0.03%]
多种人内皮细胞系中由DHFR下调引起的低氧eNOS脱耦联及其BH4再生途径的关键作用
Anna Janaszak-Jasiecka,Adrianna Radulska,Anna Siekierzycka et al.
Anna Janaszak-Jasiecka et al.
Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide synthase (eNOS), which produces nitric oxide (NO) to maintain vascular homeostasis. When BH4 is deficient, eNOS becomes uncoupled, generating superoxide (O2-) i...