Bugs as drugs: Parasite Biomolecules as Novel Therapeutics Against Breast Cancer [0.03%]
寄生虫生物分子作为对抗乳腺癌的新型药物
Said B Gonzalez,Pushkar Shivam,Destiny Ball et al.
Said B Gonzalez et al.
Contemporary breast cancer treatments include chemotherapy, surgery, and radiation therapy, all of which are invasive or accompanied by severe side effects. While emerging research suggests that parasites have unique features that may be ca...
M2 muscarinic receptor-dependent contractions of airway smooth muscle are mediated by inhibition of Kv7 channels [0.03%]
M2胆碱能受体依赖的气道平滑肌收缩由Kv7通道抑制介导
Srijit Ghosh,Kaneez E Rabab,Mark A Hollywood et al.
Srijit Ghosh et al.
Cholinergic tone is elevated in the airways of patients with COPD and asthma. Acetylcholine contracts the airways by binding to M2 and M3 muscarinic receptors on airway smooth muscle cells. The purpose of the present study was to investigat...
New insights into immunoporosis: the impact of ovariectomy on immune cell population in lymph nodes and spleen [0.03%]
免疫性骨质疏松的新见解：卵巢切除对淋巴结和脾脏中免疫细胞群的影响
Nicole Gabriele Sommer,Katharina Jandl,Begüm Okutan et al.
Nicole Gabriele Sommer et al.
It is increasingly appreciated that the immune cells and inflammatory mediators contribute to the impaired osteogenic potential under osteoporotic conditions. Previous studies in experimental animals focused on immune cells isolated from bl...
Macrophages, muscle stem cells, and repair; immunohistochemical characteristics in muscle growth impairments in children with cerebral palsy [0.03%]
儿童脑瘫肌肉生长障碍的免疫组化特征及其与巨噬细胞和肌干细胞修复的关系
Guadalupe Meza,Ryan E Kahn,Neeraj M Patel et al.
Guadalupe Meza et al.
Children with cerebral palsy (CP) have muscle growth impairments (muscle contractures), altered walking patterns and show markers of inflammation. During muscle repair macrophages coordinate with muscle stem cells-satellite cells (MuSC), wh...
MITOCHONDRIA IN MUSCLE STEM CELL BIOLOGY: GATEKEEPERS OF FATE, FUNCTION, AND REGENERATION [0.03%]
肌肉干细胞生物学中的线粒体：命运、功能和再生的 gatekeeper
Mireille Khacho,Yan Burelle
Mireille Khacho
Muscle stem cells (MuSCs) are essential for muscle regeneration, but their function declines with aging 1-4, neuromuscular disorders5-8 , and non-genetic muscle-wasting conditions9 . Their regenerative capacity is also influenced by environ...
Bioactive peptide matrikines: discovery approaches for skin rejuvenation [0.03%]
用于皮肤年轻的生物活性肽matrikine的发现方法
Tess Birtles,Zeyad El-Houni,Krishan Mistry et al.
Tess Birtles et al.
Ageing of human skin is driven in part by cumulative damage to extracellular matrix (ECM) proteins, resulting in wrinkles, laxity, and reduced capacity to heal. Bioactive peptide matrikines are promising therapeutic agents capable of stimul...
Eva A Rog-Zielinska,Jana Grune,Thorsten Kessler et al.
Eva A Rog-Zielinska et al.
The electrophysiological relevance of interstitial non-myocytes for cardiac electrophysiology arises from their abundant direct and indirect interactions with cardiac myocytes. This mini-review defines the interstitium, explores biophysical...
Interleukin-1β downregulates K+ currents through Kv1.6 channels and promotes apoptosis by enhancing Ca2+ influx in chondrocytes [0.03%]
白细胞介素-1β通过Kv1.6通道下调钾电流并促进软骨细胞凋亡的机制研究：一种新的炎症途径
Tomo Kurata,Yoshiaki Suzuki,Shinya Tateno et al.
Tomo Kurata et al.
Chronic inflammation of the knee joint can induce chondrocyte death, leading to osteoarthritis (OA). Ca2+ influx through Ca2+ channels expressed in the chondrocyte plays a key role in promoting the inflammation and chondrocyte death. Voltag...
Time of day of skeletal muscle injury is a factor in short and long term regeneration outcomes [0.03%]
骨骼肌损伤的时间会影响短期和长期的再生效果
Daniel L Scurto,Jacob M Ouellette,Tatjana A Kirincic et al.
Daniel L Scurto et al.
Skeletal muscle regeneration is a dynamic process diurnally regulated by circadian rhythms, which govern key myogenic factors. Previous studies have shown that the timing of muscle injury influences early regeneration outcomes, but it remai...
A novel cell indirect calorimetry method unveils the metabolic fluxomic signatures of human monocyte derived M(LPS+IFN-γ) and M(IL-4) macrophages [0.03%]
一种新型的细胞间接量热法揭示了人类单核细胞衍生的M（LPS+IFN-γ）和M（IL-4）巨噬细胞的代谢通量组学标志物
Gloria Cinquegrani,Valentina Spigoni,Federica Fantuzzi et al.
Gloria Cinquegrani et al.
Macrophages (MΦ) display distinct immunometabolic phenotypes upon polarization. While transcriptomic analyses have suggested divergent metabolic programs in human M(LPS+IFN-γ) and M(IL-4) MΦ, a comprehensive assessment of their metabolic...