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Insulin-regulated actin dynamics is disrupted in a human keratinocyte model of Hailey-Hailey disease

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The secretory pathway Ca2+-ATPase, SPCA1 (gene name ATP2C1), is a Golgi-localized calcium pump defective in the autosomal dominant cutaneous disorder known as Hailey-Hailey disease (HHD). Although clinically well characterized by suprabasal acantholysis and in... ...