Correction of Hypoxemia and Hypoglycemia Restores Muscle Mitochondrial Respiration and Remodels Mitochondrial Proteome in Growth-Restricted Sheep Fetuses [0.03%]
纠正生长受限羊胎盘低氧和低血糖可恢复其线粒体呼吸并重塑线粒体蛋白质组
Weicheng Zhao,Daniel B Chrisenberry,Mariangel Varela et al.
Weicheng Zhao et al.
Placental insufficiency causes fetal hypoxemia and hypoglycemia and is a major driver of fetal growth restriction (FGR). In FGR skeletal muscle, mitochondrial respiration is reduced, partially due to altered mitochondrial protein abundance....
Muscle glycogen metabolism is rapidly dysregulated in critical illness, which may have implications for muscle ATP resynthesis and ICU acquired weakness [0.03%]
肌糖原代谢在危重症早期迅速紊乱，可能影响肌肉ATP的合成并导致ICU获得性肌无力
Tom S O Jameson,Benjamin T Wall,Tomáš Urban et al.
Tom S O Jameson et al.
The association of perturbed skeletal muscle metabolism with ICU acquired weakness (ICUAW) is not clear. The objective of the present study was to characterise temporal changes in skeletal muscle mitochondrial function, ATP concentration, a...
Exercise ameliorates adipose tissue insulin resistance by activating the lactate/GPR81 signaling pathway in DIO-IR mice [0.03%]
运动通过激活DIO-IR型小鼠脂肪组织中的乳酸/GPR81信号通路改善胰岛素抵抗
Yihsuan Lin,Ge Song,Yue Chen et al.
Yihsuan Lin et al.
Growing evidence indicates that both exogenous lactate administration and physical exercise improve insulin resistance (IR). This study investigates, from a novel perspective, whether exercise-induced lactate serves as a signaling molecule ...
Novel insights into the role of Annexin A2 signaling pathway in female reproductive system diseases: from mechanisms to advanced therapies [0.03%]
annexin a2信号通路在女性生殖系统疾病中的作用机制及诊疗新进展
Yirong Ding,Yue Chen,Yu Pan et al.
Yirong Ding et al.
Annexin A2 (ANXA2) is a calcium-dependent protein with high affinity for phospholipids, and its multifunctional nature has drawn increasing attention in the onset and progression of various disorders of the female reproductive system (FRS)....
A role for vagal activity in preventing the suppression of glucagon secretion by GLP-1 during hypoglycemia [0.03%]
迷走神经活性在低血糖期间防止GLP-1抑制胰高血糖素分泌中的作用
Carolina B Lobato,Amalie B E Nielsen,Jens J Holst
Carolina B Lobato
GLP-1 is generally safe against hypoglycemia, although it stimulates insulin and inhibits glucagon secretion. One explanation is that glucagon secretion is not inhibited by GLP-1 during hypoglycemia. We aimed at understanding the lack of su...
Pre-transplant Aerobic Exercise Improves Glycemic Outcomes After Marginal Islet Mass Transplantation in Rats [0.03%]
术前有氧运动可改善低移植胰岛细胞量后的血糖预后：大鼠模型研究
Jordan M Wong,Seyed Amirhossein Tabatabaei Dakhili,Purushothaman Kuppan et al.
Jordan M Wong et al.
Pancreatic islet transplantation (ITx) improves glycemic management and prevents severe hypoglycemia in select individuals with type 1 diabetes (T1D). However, insulin independence cannot be guaranteed due to transplant and recipient-specif...
Evidence for a Role of Calcium and Vitamin D in the Regulation of Manganese Homeostasis and in the Prevention or Management of Manganese Induced Disease [0.03%]
钙和维生素D在锰稳态调节中的作用及其在预防或治疗由锰引起疾病中的作用的证据
Hope Lee,Sarah Marie Gerges,Simran Gill et al.
Hope Lee et al.
SLC30A10 mediates Mn efflux in both intestine and liver, protecting against Mn toxicity. In previous studies we found that Slc30a10 is one of the genes most induced by 1,25(OH)2D3 in mouse intestine and human enteroids. In addition, in Slc3...
Impact of infusing the cholesterol precursor mevalonate on the hypocholesterolemia of sepsis and its potential consequences: a paradoxical response [0.03%]
胆固醇前体物质甲羟戊酸在 infusion 对脓毒症低胆固醇水平的影响及其潜在后果：一种矛盾的反应
Lauren De Bruyn,Sarah Derde,Fien Van Beek et al.
Lauren De Bruyn et al.
Hypocholesterolemia hallmarks sepsis, though its pathophysiology and tissue-specific consequences are unclear. As low circulating cholesterol may reflect impaired endogenous cholesterol synthesis, we hypothesized that infusion of the choles...
How long should washout be to reliably measure hepatic de novo lipogenesis using deuterated water?; Exploratory analysis from a randomised crossover trial [0.03%]
氘水测定肝脏脱氧脂质生成的研究中洗脱期应该有多长？一项随机交叉试验的探索性分析结果
Steven Carter,Louise Bradshaw,Bruno Spellanzon et al.
Steven Carter et al.
Deuterated water (2H2O) can be used to measure de novo lipogenesis (DNL) with minimal participant burden, but implications of tracer washout on repeated measures in humans are unclear. This study is an exploratory analysis of data from a cr...