GLP-1 from the distal gut is dispensable for body weight and glucose regulation but slows small intestinal transit in female mice [0.03%]
远端肠道的GLP-1对于体重和葡萄糖调节是可有可无的，但可以减慢雌性小鼠的小肠转运速度
Thomas Uwe Greiner,Randy J Seeley,Fredrik Bäckhed
Thomas Uwe Greiner
Enteroendocrine cells (EECs) are specialized cells located throughout the gastrointestinal (GI) tract where they have an essential role in regulating various physiological processes related to digestion, metabolism, and gut physiology. EECs...
Xi Hu,Donghua Hu,Kun Chen et al.
Xi Hu et al.
UCP1, a mitochondrial protein traditionally regarded as exclusive to thermogenic adipocytes, and Ucp1-promoter-driven Cre is widely used in gene manipulation in thermogenic adipocytes. However, new evidence suggests that Ucp1-promoter-drive...
Intranasal insulin affects brain, but not peripheral tissue, glucose uptake in lean, healthy men - a positron emission tomography study [0.03%]
鼻内给药的胰岛素影响健康男性大脑而非周边组织的葡萄糖摄取-正电子放射断层扫描研究
Aino Latva-Rasku,Sanna Laurila,Tomi Karjalainen et al.
Aino Latva-Rasku et al.
The brain has been suggested to regulate glucose metabolism in response to insulin in various tissues. As many of these findings have not been studied in humans, we aimed to assess the effects of intranasal insulin (INI) on brain and periph...
The Role of Orosomucoid in Glucose and lipid Metabolism and Metabolic Diseases [0.03%]
血清白蛋白.orosomucoid在糖脂代谢及代谢性疾病中的作用
Xueli Zhang,Dongsheng Shang,Xia Deng et al.
Xueli Zhang et al.
Dysregulation of glucose and lipid metabolism is closely linked to metabolic diseases such as obesity, diabetes, and diabetic nephropathy, posing serious threats to human health. Orosomucoid (ORM), an acute-phase protein, exhibits diverse b...
Interplay between expression of PD-L1 on thyrocytes and intrathyroidal lymphocytes and FOXP3 as a marker of regulatory T lymphocytes in Hashimoto thyroiditis [0.03%]
桥本甲状腺炎中甲状腺细胞PD-L1表达与淋巴细胞浸润及调节性T淋巴细胞标志物FOXP3的关系研究
Ana Carolina Barros Silva,Ingrid Iara Damas,Camila Aparecida Moma et al.
Ana Carolina Barros Silva et al.
Introduction: Hashimoto's thyroiditis (HT) is a prevalent autoimmune disease marked by lymphocytic infiltration and progressive destruction of the thyroid gland. The pathogenesis involves cytotoxic T lymphocytes, while regulatory T cells (T...
Relationship Between Aerobic Fitness and Adipose Tissue Insulin Resistance [0.03%]
有氧运动与脂肪组织胰岛素抵抗之间的关系
Arunima Sharma,Kelli Lytle,Michael D Jensen
Arunima Sharma
Objective: Aerobic fitness is associated with greater skeletal muscle insulin sensitivity with regards to glucose uptake. Whether fitness is associated with an improvement in the insulin36 regulation of adipose tissue lip...
Colleen R Bocke,Niloufarsadat Mirian,Rachel Schafer et al.
Colleen R Bocke et al.
Cocaine- and amphetamine-regulated transcript peptide inhibits food and water intake in rodents and there is evidence that the peptide interacts with the previously orphaned G protein-coupled receptor GPR160. In addition, the peptide transm...
Concurrent Increase in Fatty Acid Oxidation and Fatty acid Synthesis: A Unique Metabolic State in a Pig Model of Pediatric Steatotic Liver Disease [0.03%]
脂肪酸氧化和脂肪酸合成并发增加：儿童肝脂肪变性疾病的猪模型中的独特代谢状态
Ravi Yadav,Marta R M Lima,Ryan P McMillan et al.
Ravi Yadav et al.
Steatotic liver disease (SLD) is a spectrum of chronic and progressive disorders. While often associated with obesity, it can afflict individuals without obesity, including infants. We previously reported that neonatal pigs fed formulas enr...
Assessing the Rate-Dependence of the First Phase of Glucose-Stimulated Insulin Secretion: Dynamic Perifusion Studies with Isolated Human Pancreatic Islets [0.03%]
动态分配实验测定人胰岛细胞葡萄糖刺激的第一阶段分泌反应对其刺激频率的依赖性研究
Peter Buchwald,Sung-Ting Chuang,Brandon Watts et al.
Peter Buchwald et al.
Insulin released in response to a stepwise increase in glucose (square wave) is biphasic with a transient 5-10 min first-phase peak and a more sustained second phase. While the first phase is generally assumed to be rate-dependent and the s...
Insulin Resistance and SIK1 Hyperactivation: Implications for Vascular Remodeling in Recurrent Pregnancy Loss [0.03%]
胰岛素抵抗与SIK1高活化：反复妊娠丢失血管重塑的含义
Tianyuan Qi,Jing Tang,Dongyan Wang et al.
Tianyuan Qi et al.
Recurrent pregnancy loss (RPL) is a multifactorial condition, with nearly half of cases remaining unexplained, and maternal insulin resistance is identified as a significant contributor. This study examined the role of SIK1 in RPL patients ...