Non-equilibrium Thermodynamic Analysis of Human Bioenergetics in Obesity: Implications of the Second Law [0.03%]
Nawfal Istfan
Nawfal Istfan
The fundamental principle of energy balance, a statement of the first law of thermodynamics, overlooks the second law, resulting in gaps in our knowledge of body weight regulation and obesity. This study develops research tools to implement...
Ashraf Al Madhoun,Anwar Mohammad,Mohamed Abu-Farha et al.
Ashraf Al Madhoun et al.
Furin, a proprotein convertase, regulates glucose homeostasis by processing the insulin receptor precursor. While the association of furin genetic variants with cardiac and neuronal diseases is well-established, studies investigating the as...
Metabolic Pathways and Male Fertility: Exploring the Role of Sertoli Cells in Energy Homeostasis and Spermatogenesis [0.03%]
Zi-Feng Chen,Yi-Feng Shen,Da-Wei Gao et al.
Zi-Feng Chen et al.
Globalization has driven a surge in noncommunicable diseases, including metabolic disorders, which are major global health challenges. These disorders, fueled by high-calorie diets, sedentary lifestyles, and gut microbiota imbalances, disru...
HDAC1 deacetylates PGC-1α and its inhibition improves glucose homeostasis in diet-induced obese mice [0.03%]
Chaim Atay Fainshtein,Or Maalumi,Keren-El De-Leon et al.
Chaim Atay Fainshtein et al.
Excessive hepatic glucose production (HGP) driven by increased gluconeogenesis is a hallmark of type 2 diabetes, making its inhibition a crucial strategy for reducing hyperglycemia. Central to HGP regulation is the transcriptional co-activa...
Thermogenesis and reduced lipid synthesis: one-anastomosis gastric bypass bariatric surgery 6-month follow ups in adipose tissue context for type 2 diabetes [0.03%]
一种胃旁路手术6个月随访：糖尿病患者脂肪组织中的生热作用和脂质合成减少
I Stafeev,M Agareva,S Michurina et al.
I Stafeev et al.
Background: One-anastomosis gastric bypass (OAGB) represents a novel less invasive bariatric surgery technique which can significantly improve systemic metabolism and adipose tissue health in type 2 diabetes mellitus (T2DM) patients. Previo...
Genealogical Rabson-Mendenhall syndrome caused by INSR Gene Mutation [0.03%]
INSR基因突变所致谱系Rabson-Mendenhall综合征
Xuewen Yuan,Ziyang Zhu,Chao Liang
Xuewen Yuan
Background: Rabson-Mendenhall syndrome (RMS) is a rare autosomal recessive disorder caused by mutations in the insulin receptor (INSR) gene, leading to severe insulin resistance. Clinical manifestations of RMS include hypertrichosis and aca...
Genevieve L Fernandes,Deodatta S Gajbhiye,Yaara Y Columbus-Shenkar et al.
Genevieve L Fernandes et al.
Growth hormone (Gh) is the main regulator of fish growth, making it vital to understand how Gh is controlled. However, studying Gh regulation has been limited by the lack of suitable fish models. We identified conserved regulatory elements ...
Maladaptive Trained Immunity of Adipose Tissue Macrophages Unraveling the Links to Obesity, T2DM, and Beyond [0.03%]
不适应训练免疫的脂肪组织巨噬细胞及其与肥胖、2型糖尿病等的关系
Siyi Chen,Jiayao Fu,Jiayu Yan et al.
Siyi Chen et al.
Maladaptive Trained Immunity and associated chronic low-grade inflammation contribute to metabolic diseases, including obesity, type 2 diabetes mellitus (T2DM), and cardiometabolic disorders. The heterogeneity and plasticity of adipose tiss...
Adipose tissue protein kinase D (PKD): regulation of signalling networks and its sex-dependent effects on metabolism [0.03%]
脂肪组织蛋白激酶D（PKD）：信号网络的调节及其对代谢的性别依赖性影响
Mark C Renton,Sean J Humphrey,Tim Connor et al.
Mark C Renton et al.
The protein kinase D (PKD) family of three highly homologous isoforms (PKD1, PKD2, and PKD3) are implicated as nutrient sensing signalling kinases that regulate the response of adipose and other tissues to the nutrient environment. However,...