A noninvasive 13C-mannitol breath test to monitor semaglutide treatment-induced delayed oral-cecal transit in mice [0.03%]
通过13C-甘露醇呼吸试验监测利拉鲁肽治疗引起的小鼠口服至盲肠转运延迟的一种无创方法
Daniel E Vieira,Emily M Langmeyer,Marissa D Cortopassi et al.
Daniel E Vieira et al.
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide, are highly effective treatments for obesity and type 2 diabetes but are often associated with gastrointestinal side effects including delayed transit times through t...
Mechanistic drivers of thermogenic adipose tissue dysfunction in aging and obesity [0.03%]
衰老和肥胖状态下生热脂肪组织功能障碍的机制驱动因素
Gabriela Ueta Ortiz,Gabriela Ferreira Abud,Caroline Fogagnolo et al.
Gabriela Ueta Ortiz et al.
Population aging is accelerating worldwide and is accompanied by a growing burden of chronic metabolic diseases. Adipose tissue dysfunction represents a central mechanism linking aging and obesity to metabolic decline, contributing to chron...
Validation in Adult Black and White Women of the ISS Model for Estimating Insulin Sensitivity and Beta-Cell Function from Mixed Meal Tests [0.03%]
用混合餐试验估算胰岛素敏感性及β细胞功能的ISS模型在成年黑白种人女性中的验证效果研究
Arthur S Sherman,Nathan Sala,Anne E Sumner et al.
Arthur S Sherman et al.
The ISS (Insulin Secretion and Sensitivity) differential equation model has been previously shown to provide simultaneous estimates of SI and BCF during an oral glucose tolerance test. Using the Federal Women's Study, we adapted the ISS mod...
Multi-omics approaches reveal direct NF-κB p65 target genes in pancreatic islets during cytokine exposure and in Type 1 diabetes [0.03%]
多组学方法揭示细胞因子暴露过程中和1型糖尿病中胰岛直接NF-κB p65靶基因
Thomas M Martin,Susan J Burke,Heidi M Batdorf et al.
Thomas M Martin et al.
Autoimmune diseases, including Type 1 diabetes (T1D), are often characterized by overactive inflammatory signaling pathways. The pro-inflammatory cytokine interleukin-1β (IL-1β) elicits global gene expression changes in islet β-cells whi...
Glucagon receptor deficiency is associated with glucocorticoid receptor activation and proteolytic remodeling in gastrocnemius of male mice [0.03%]
男鼠的小腿肌中胰高血糖素受体缺乏与糖皮质激素受体激活和蛋白水解重构有关
Xuanxuan Bai,Tongyu Zhang,Chao Zhang et al.
Xuanxuan Bai et al.
Glucagon receptor (GCGR) signaling plays a central role in systemic metabolic regulation. However, its role in skeletal muscle protein homeostasis remains poorly understood. In this study, we demonstrated that skeletal muscle from male GCGR...
Nr4a3 Deficiency Disrupts MEK1-ERK1/2-Drp1 Signaling, Driving Adiposity and Glucose Intolerance in Male Mice [0.03%]
Nr4a3缺陷通过破坏MEK1-ERK1/2-Drp1信号传导促进雄性小鼠肥胖和葡萄糖耐受不良
Peter N Ellsworth,Kate E Whalen,Jared D Carter et al.
Peter N Ellsworth et al.
Obesity is strongly associated with elevated blood glucose levels, glucose intolerance, insulin resistance and type 2 diabetes. The Nr4a family of orphan nuclear receptors are essential for proliferation, cell survival, mitochondrial functi...
Cuiying Xiao,Tamar Demby,Naili Liu et al.
Cuiying Xiao et al.
The ability to tightly regulate and maintain a warm core body temperature (Tb) is a defining characteristic of homeotherms. Moving to a thermally preferred place is an energetically efficient first-line thermoregulatory mechanism. We optimi...
Application of 13C MRS demonstrates carbohydrate feeding spares muscle but not liver glycogen utilisation during high-intensity interval exercise [0.03%]
应用~13C磁共振波谱技术证明摄入碳水化合物会优先保留肌糖原而不是肝糖原的利用以应对高强度间歇运动
Sophie C Hannon,Libby Henthorn,Jay Vadher et al.
Sophie C Hannon et al.
We examined liver and muscle glycogen utilisation during high-intensity interval cycling, and the impact of carbohydrate (CHO) feeding, using non-invasive 13C magnetic resonance spectroscopy (MRS). Following 24 h of standardised dietary int...
β-hydroxybutyrate: A Renoprotective Hormone In Polycystic Kidney Disease [0.03%]
β-羟丁酸：一种多囊肾病的肾脏保护激素
Jacob A Torres,Elizabeth H Sharpe,Thomas Weimbs
Jacob A Torres
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic form of chronic kidney disease characterized by highly variable rates of progression. This variability suggests that nutritional, lifestyle, and environmental factors ...
GDF15 modulates mitochondrial content and differentiation-associated metabolic remodeling in skeletal muscle cells [0.03%]
GDF15调节骨骼肌细胞中的线粒体含量和分化相关代谢重塑
Bianca Cristine Favero-Santos,Carolina Martins Lazaro,Jung Tae Kim et al.
Bianca Cristine Favero-Santos et al.
Growth differentiation factor 15 (GDF15) is a distant member of the transforming growth factor-β (TGF-β) superfamily increasingly implicated in metabolic regulation. Evidence points to GDF15 as a myokine that regulates systemic energy hom...