The Impact of Maternal Metabolic Flexibility During Gestation on Infant Adiposity in Individuals with Obesity [0.03%]
肥胖个体母体代谢灵活性对婴儿脂肪的影响
Kaja Falkenhain,Nicholas T Broskey,Jasper Most et al.
Kaja Falkenhain et al.
Maternal metabolism adapts during pregnancy to support fetal growth, yet how variability in maternal substrate oxidation influences neonatal adiposity is not well understood. Metabolic flexibility - the ability to adapt to substrate availab...
Exercise Combined with Dietary Switch Improves MASLD by Suppressing Hepatic MOGAT1 and Modulating Metabolic Stress Pathways in HFD-Fed Mice [0.03%]
联合运动和饮食改善高脂喂养小鼠MASLD的机制研究：通过抑制肝脏MOGAT1并调节代谢压力通路实现
Jong-Hwa Won,Kyung-Wan Baek,Ying-Ying Xiang et al.
Jong-Hwa Won et al.
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a progressive liver disorder that can lead to irreversible hepatic damage when chronic inflammation and fibrosis develop. Exercise and dietary switch have been suggested as...
Pioglitazone increases adiponectin and attenuates the appearance of diet-induced insulin resistance in high-fat-fed beagles [0.03%]
吡格列酮升高脂联素水平并减轻高脂喂养比格犬诱导的胰岛素抵抗
Guillaume Kraft,Ashley Tovar,Kalisha Yankey et al.
Guillaume Kraft et al.
This study investigated the efficacy of thiazolidinediones in mitigating diet-induced obesity and associated glucose intolerance in canines in vivo. We used a multi technique approach and compared the results related to a) fasting metabolit...
Heterogeneity in postprandial glucose-insulin and triacylglycerol dynamics and associations with plasma metabolome and body composition in obesity [0.03%]
肥胖症患者餐后血糖-胰岛素和三酰甘油动态异质性及其与血浆代谢组和体组成的关系研究
Nikolai B Aunbakk,Siv Kjølsrud Bøhn,Johnny Laupsa-Borge et al.
Nikolai B Aunbakk et al.
We are only beginning to understand the extent and reasons for the individual variation in postprandial response dynamics in key hormones and metabolites such as insulin, glucose and triacylglycerols (TAGs). More nuanced statistical approac...
Alterations in glucocorticoid homeostasis following sleeve gastrectomy in male mice [0.03%]
公鼠袖状胃切除术后的糖皮质激素稳态改变
Seraina O Moser,Andrei Moscalu,Cullen F Roberts et al.
Seraina O Moser et al.
Elevated intra-tissue levels of active glucocorticoids in patients with obesity are associated with insulin resistance, diabetes, impaired immune regulation, and other adverse effects. Sleeve gastrectomy (SG) induces significant weight loss...
Influence of Metformin on Exercise Metabolism and Capacity: A Systematic Review and Meta-Analysis [0.03%]
二甲双胍对运动代谢和能力影响的系统综述和meta分析
Emily E Grammer,Macy E Stahl,Joaquin Ortiz de Zevallos et al.
Emily E Grammer et al.
Metformin and exercise are often co-prescribed in adults with prediabetes and type 2 diabetes mellitus (T2DM). However, metformin may alter metabolic responses to exercise. This systematic review and meta-analysis evaluated the impact of me...
Acute overfeeding impairs meal-stimulated adipose tissue microvascular blood flow in healthy adults independent of changes in adiposity [0.03%]
短期过量饮食可损害健康成年人的餐后脂肪组织微血管血流量分布独立于体脂变化之外
Barbara Brayner,Shaun Mason,Elmira Karimi et al.
Barbara Brayner et al.
Subcutaneous adipose tissue microvascular blood flow (MBF) increases in response to insulin or a meal, with gastric inhibitory polypeptide (GIP) being a proposed mechanism. This vascular response is blunted in people with insulin resistance...
Undernutrition-Related Diabetes in Mice is Linked to Early Undernutrition [0.03%]
小鼠与早期营养不良相关的糖尿病与早期营养不良有关
Elvia Y Osorio,Zbigniew Gugala,Ichiaki Ito et al.
Elvia Y Osorio et al.
The classification of undernutrition-related diabetes as a distinct entity separate from Type 1 and Type 2 diabetes, remains under debate. Here, we show that post-natal undernutrition induces coordinated transcriptional, metabolic, and path...
Nuria López-Alcántara,Lena Adam,Julia Resch et al.
Nuria López-Alcántara et al.
Thyroid hormone (TH) is a key regulator of body temperature; however, its role in the tightly controlled maternal thermoregulatory system that safeguards fetal viability remains unknown. To address this gap, we investigated how maternal hyp...