Roles of the noradrenergic nucleus locus coeruleus and dopaminergic nucleus A11 region as supraspinal defecation centers in rats [0.03%]
noradrenergic nucleus locus coeruleus和dopaminergic核A11区作为大鼠排便中枢的作用研究
Hiroyuki Nakamori,Kiyotada Naitou,Yuuki Horii et al.
Hiroyuki Nakamori et al.
We previously demonstrated that administration of norepinephrine, dopamine, and serotonin into the lumbosacral defecation center caused propulsive contractions of the colorectum. It is known that the monoamines in the spinal cord are releas...
Posttraumatic stress disorder is associated with altered gut microbiota that modulates cognitive performance in veterans with cirrhosis [0.03%]
创伤后应激障碍与肝硬化的退伍军人肠道菌群改变并调节认知功能相关
Jasmohan S Bajaj,Masoumeh Sikaroodi,Andrew Fagan et al.
Jasmohan S Bajaj et al.
Posttraumatic stress disorder (PTSD) is associated with cirrhosis in veterans, and therapeutic results are suboptimal. An altered gut-liver-brain axis exists in cirrhosis due to hepatic encephalopathy (HE), but the added impact of PTSD is u...
Liraglutide improves hepatic steatosis and metabolic dysfunctions in a 3-week dietary mouse model of nonalcoholic steatohepatitis [0.03%]
利拉鲁肽改善非酒精性脂肪肝病小鼠模型的肝脏脂质沉积和代谢障碍
Thibaut Duparc,François Briand,Charlotte Trenteseaux et al.
Thibaut Duparc et al.
Nonalcoholic steatohepatitis (NASH) is an emerging health problem worldwide. However, efficacious pharmacological treatment for NASH is lacking. A major issue for preclinical evaluation of potential therapeutics for NASH is the limited numb...
Extracellular release of ATP promotes systemic inflammation during acute pancreatitis [0.03%]
细胞外ATP释放在急性胰腺炎时系统性炎症中的促进作用
Ajay Dixit,Hassam Cheema,John George et al.
Ajay Dixit et al.
In the current study, we explored the role of extracellular ATP (eATP) in promoting systemic inflammation during development of acute pancreatitis (AP). Release of extracellular (e)ATP was evaluated in plasma and bronchoalveolar lavage flui...
LINC00319 acts as a microRNA-335-5p sponge to accelerate tumor growth and metastasis in gastric cancer by upregulating ADCY3 [0.03%]
长链非编码RNA LINC00319通过上调ADCY3充当microRNA-335-5P海绵促进胃癌生长和转移的作用机制研究
Jun Zou,Kun Wu,Chao Lin et al.
Jun Zou et al.
Gastric cancer (GC) is one of the most common cancers in the world and remains a heavy burden of health worldwide. Adenylate cyclase 3 (ADCY3) is a widely expressed membrane-associated protein in human tissues and has been identified to be ...
Vaccine against gastrin, a polyclonal antibody stimulator, decreases pancreatic cancer metastases [0.03%]
胃泌素多克隆抗体刺激疫苗可减少胰腺癌转移
Nicholas Osborne,Rebecca Sundseth,Martha D Gay et al.
Nicholas Osborne et al.
Growth of pancreatic cancer is stimulated by gastrin in both a paracrine and an autocrine fashion. Traditional therapies have not significantly improved survival, and recently pancreatic cancer has been deemed a "cold" tumor due to its poor...
Enteroids expressing a disease-associated mutant of EpCAM are a model for congenital tufting enteropathy [0.03%]
表达与疾病相关突变的EpCAM类器官是先天性丛状肠病的模型
Barun Das,Kevin Okamoto,John Rabalais et al.
Barun Das et al.
Congenital tufting enteropathy (CTE) is an autosomal recessive disease characterized by severe intestinal failure in infancy and mutations in the epithelial cell adhesion molecule (EPCAM) gene. Previous studies of CTE in mice expressing mut...
Digoxin improves steatohepatitis with differential involvement of liver cell subsets in mice through inhibition of PKM2 transactivation [0.03%]
Digitoxin通过抑制PKM2转录激活改善小鼠的肝细胞亚群依赖性脂肪性肝炎
Peng Zhao,Sheng-Na Han,Suyavaran Arumugam et al.
Peng Zhao et al.
The cardiac glycoside digoxin was identified as a potent suppressor of pyruvate kinase isoform 2-hypoxia-inducible factor-α (PKM2-HIF-1α) pathway activation in liver injury mouse models via intraperitoneal injection. We have assessed the ...
Optogenetic analysis of neuromuscular transmission in the colon of ChAT-ChR2-YFP BAC transgenic mice [0.03%]
胆碱乙酰转移酶-通道视紫红质黄色荧光蛋白基因敲入小鼠结肠神经肌肉传递的光遗传学研究
Alberto L Perez-Medina,James J Galligan
Alberto L Perez-Medina
Propulsion of luminal content along the gut requires coordinated contractions and relaxations of gastrointestinal smooth muscles controlled by the enteric nervous system. Activation of excitatory motor neurons (EMNs) causes muscle contracti...
Admission plasma uromodulin and the risk of acute kidney injury in hospitalized patients with cirrhosis: a pilot study [0.03%]
尿毒霉素与住院肝硬化患者急性肾损伤风险的相关性：一项试点研究
Kavish R Patidar,Pranav S Garimella,Etienne Macedo et al.
Kavish R Patidar et al.
Acute kidney injury (AKI) is a common complication in hospitalized patients with cirrhosis. Uromodulin, a protein uniquely produced by the kidney and released both in the urine and circulation, has been shown to regulate AKI and is linked t...